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Nonlinear Mixed Effects models (NLME) models are widely used in pharmacometrics and related fields to analyze hierarchical and longitudinal data. However, as the number of parameters and random effects increases, traditional methods for…

Methodology · Statistics 2026-04-30 Mohamed Tarek , Pedro Afonso

In biomedical studies, we are often interested in the association between different types of covariates and the times to disease events. Because the relationship between the covariates and event times is often complex, standard survival…

Methodology · Statistics 2024-01-19 Hoi Min Ng , Kin Yau Wong

Offline reinforcement learning (RL) can fit strong value functions from fixed datasets, yet reliable deployment still hinges on the action selection interface used to query them. When the dataset induces a branched or multimodal action…

Machine Learning · Computer Science 2026-03-25 Haoyu Wang , Jingcheng Wang , Shunyu Wu , Xinwei Xiao

We address the problem of estimating heterogeneous treatment effects in panel data, adopting the popular Difference-in-Differences (DiD) framework under the conditional parallel trends assumption. We propose a novel doubly robust…

Machine Learning · Statistics 2025-04-29 Hui Lan , Haoge Chang , Eleanor Dillon , Vasilis Syrgkanis

Analyzing individual emotions during group conversation is crucial in developing intelligent agents capable of natural human-machine interaction. While reliable emotion recognition techniques depend on different modalities (text, audio,…

We provide an information-theoretic framework for studying the generalization properties of machine learning algorithms. Our framework ties together existing approaches, including uniform convergence bounds and recent methods for adaptive…

Machine Learning · Computer Science 2020-06-22 Thomas Steinke , Lydia Zakynthinou

Reinforcement learning (RL) enables an agent interacting with an unknown MDP $M$ to optimise its behaviour by observing transitions sampled from $M$. A natural entity that emerges in the agent's reasoning is $\widehat{M}$, the maximum…

Machine Learning · Computer Science 2025-02-24 Shivaram Kalyanakrishnan , Sheel Shah , Santhosh Kumar Guguloth

Traditional causal inference approaches leverage observational study data to estimate the difference in observed and unobserved outcomes for a potential treatment, known as the Conditional Average Treatment Effect (CATE). However, CATE…

Machine Learning · Statistics 2022-09-22 Tianhui Zhou , William E Carson , David Carlson

Covariate-specific treatment effects (CSTEs) represent heterogeneous treatment effects across subpopulations defined by certain selected covariates. In this article, we consider marginal structural models where CSTEs are linearly…

Methodology · Statistics 2021-05-25 Peng Wu , Zhiqiang Tan , Wenjie Hu , Xiao-Hua Zhou

As Large Language Models (LLMs) are increasingly deployed to handle various natural language processing (NLP) tasks, concerns regarding the potential negative societal impacts of LLM-generated content have also arisen. To evaluate the…

Computation and Language · Computer Science 2025-02-25 Song Wang , Peng Wang , Tong Zhou , Yushun Dong , Zhen Tan , Jundong Li

The conditional average treatment effect (CATE) is the best measure of individual causal effects given baseline covariates. However, the CATE only captures the (conditional) average, and can overlook risks and tail events, which are…

Machine Learning · Statistics 2025-06-05 Nathan Kallus , Miruna Oprescu

A novel data-driven methodology is presented for the joint selection of prior parameters for both fixed and random effects in Linear Mixed Models (LMMs). This approach facilitates the estimation of complex random-effects structures, as well…

Methodology · Statistics 2026-04-28 Matteo Amestoy , R. Vermeulen , Mark A. van de Wiel , Wessel N. van Wieringen

Approximate Bayesian Computation is widely used to infer the parameters of discrete-state continuous-time Markov networks. In this work, we focus on models that are governed by the Chemical Master Equation (the CME). Whilst originally…

Quantitative Methods · Quantitative Biology 2020-01-10 Christopher Lester

A new meta-algorithm for estimating the conditional average treatment effects is proposed in the paper. The main idea underlying the algorithm is to consider a new dataset consisting of feature vectors produced by means of concatenation of…

Machine Learning · Statistics 2019-09-10 Lev V. Utkin , Mikhail V. Kots , Viacheslav S. Chukanov

Adaptive machine learning (ML) aims to allow ML models to adapt to ever-changing environments with potential concept drift after model deployment. Traditionally, adaptive ML requires a new dataset to be manually labeled to tailor deployed…

Machine Learning · Computer Science 2024-04-10 Yutian Ren , Aaron Haohua Yen , G. P. Li

We propose a double/debiased machine learning framework to estimate average derivative effects in nonparametric panel models with two-way fixed effects. It extends instrumental variable methods to panel settings, handles continuous…

Methodology · Statistics 2026-05-19 Peikai Wu , Kuan Sun , Zhiguo Xiao

A well-informed recommendation framework could not only help users identify their interested items, but also benefit the revenue of various online platforms (e.g., e-commerce, social media). Traditional recommendation models usually assume…

Information Retrieval · Computer Science 2022-03-29 Wei Wei , Chao Huang , Lianghao Xia , Yong Xu , Jiashu Zhao , Dawei Yin

Generalized additive models (GAMs) offer interpretability through independent univariate feature effects but underfit when interactions are present in data. GA$^2$Ms add selected pairwise interactions which improves accuracy, but sacrifices…

Discriminant analysis is a useful classification method. Variable selection for discriminant analysis is becoming more and more im- portant in a high-dimensional setting. This paper is concerned with the binary-class problems of main and…

Methodology · Statistics 2017-02-16 Deqiang Zheng , Jinzhu Jia , Xiangzhong Fang , Xiuhua Guo

Several epidemiological studies have provided evidence that long-term exposure to fine particulate matter (PM2.5) increases mortality risk. Furthermore, some population characteristics (e.g., age, race, and socioeconomic status) might play…

Methodology · Statistics 2023-11-01 Dafne Zorzetto , Falco J. Bargagli-Stoffi , Antonio Canale , Francesca Dominici