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In order to understand the complexities of cellular biology, researchers are interested in two important metrics: the genetic expression information of cells and their spatial coordinates within a tissue sample. However, state-of-the art…

Machine Learning · Computer Science 2023-11-02 J. Ding , S. N. Zaman , P. Y. Chen , D. Wang

Time series analysis has emerged as an important tool for improving patient diagnosis and management in healthcare applications. However, these applications commonly face two critical challenges: time misalignment and data sparsity.…

Machine Learning · Statistics 2025-09-25 Dohyun Ku , Catherine D. Chong , Visar Berisha , Todd J. Schwedt , Jing Li

With the emergence of advanced spatial transcriptomic technologies, there has been a surge in research papers dedicated to analyzing spatial transcriptomics data, resulting in significant contributions to our understanding of biology. The…

Genomics · Quantitative Biology 2024-04-11 Sikta Das Adhikari , Jiaxin Yang , Jianrong Wang , Yuehua Cui

Data augmentation for domain-specific image classification tasks often struggles to simultaneously address diversity, faithfulness, and label clarity of generated data, leading to suboptimal performance in downstream tasks. While existing…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Yixuan Dong , Fang-Yi Su , Jung-Hsien Chiang

3D Swin Transformer (3D-ST) known for its hierarchical attention and window-based processing, excels in capturing intricate spatial relationships within images. Spatial-spectral Transformer (SST), meanwhile, specializes in modeling…

Computer Vision and Pattern Recognition · Computer Science 2024-09-27 Muhammad Ahmad , Manuel Mazzara , Salvatore Distifano

Hyperspectral Image (HSI) classification is an important issue in remote sensing field with extensive applications in earth science. In recent years, a large number of deep learning-based HSI classification methods have been proposed.…

Computer Vision and Pattern Recognition · Computer Science 2023-09-04 Ning Chen , Jun Yue , Leyuan Fang , Shaobo Xia

We present an approach to denoising spatial transcriptomics images that is particularly effective for uncovering cell identities in the regime of ultra-low sequencing depths, and also allows for interpolation of gene expression. The method…

Diffusion models have gained attention for their ability to represent complex distributions and incorporate uncertainty, making them ideal for robust predictions in the presence of noisy or incomplete data. In this study, we develop and…

Machine Learning · Computer Science 2024-11-05 Yilin Zhuang , Sibo Cheng , Karthik Duraisamy

Spatial transcriptomics assays are rapidly increasing in scale and complexity, making computational analysis a major bottleneck in biological discovery. Although frontier AI agents have improved dramatically at software engineering and…

Artificial Intelligence · Computer Science 2026-01-06 Kenny Workman , Zhen Yang , Harihara Muralidharan , Hannah Le

Recent advances in computational pathology have leveraged vision-language models to learn joint representations of Hematoxylin and Eosin (HE) images with spatial transcriptomic (ST) profiles. However, existing approaches typically align HE…

Spiking neural networks (SNNs), inspired by the spiking behavior of biological neurons, offer a distinctive approach for capturing the complexities of temporal data. However, their potential for spatial modeling in multivariate time-series…

Machine Learning · Computer Science 2025-08-19 Bang Hu , Changze Lv , Mingjie Li , Yunpeng Liu , Xiaoqing Zheng , Fengzhe Zhang , Wei cao , Fan Zhang

Despite the impressive performance across a wide range of applications, current computational pathology models face significant diagnostic efficiency challenges due to their reliance on high-magnification whole-slide image analysis. This…

Image and Video Processing · Electrical Eng. & Systems 2025-06-04 Chu Han , Bingchao Zhao , Jiatai Lin , Shanshan Lyu , Longfei Wang , Tianpeng Deng , Cheng Lu , Changhong Liang , Hannah Y. Wen , Xiaojing Guo , Zhenwei Shi , Zaiyi Liu

Spatial-temporal data, fundamental to many intelligent applications, reveals dependencies indicating causal links between present measurements at specific locations and historical data at the same or other locations. Within this context,…

Machine Learning · Computer Science 2025-01-16 Wenying Duan , Shujun Guo , Wei huang , Hong Rao , Xiaoxi He

Spatiotemporal learning plays a crucial role in mobile computing techniques to empower smart cites. While existing research has made great efforts to achieve accurate predictions on the overall dataset, they still neglect the significant…

Machine Learning · Computer Science 2024-03-20 Gengyu Lin , Zhengyang Zhou , Qihe Huang , Kuo Yang , Shifen Cheng , Yang Wang

Triggered by the success of transformers in various visual tasks, the spatial self-attention mechanism has recently attracted more and more attention in the computer vision community. However, we empirically found that a typical vision…

Computer Vision and Pattern Recognition · Computer Science 2022-11-28 Jiayin Sun , Hong Wang , Qiulei Dong

Spatial transcriptomics offers spatially resolved gene expression profiling within tissue sections, but its cost and limited throughput hinder large-scale deployment. To extend this capability to routine practice, recent computational…

Machine Learning · Computer Science 2026-05-07 Keunho Byeon , Jin Tae Kwak

Motivated by problems from neuroimaging in which existing approaches make use of "mass univariate" analysis which neglects spatial structure entirely, but the full joint modelling of all quantities of interest is computationally infeasible,…

Methodology · Statistics 2022-04-19 Denishrouf Thesingarajah , Adam M. Johansen

Diffusion models have emerged as a powerful tool for generating high-quality images, videos, and 3D content. While sampling guidance techniques like CFG improve quality, they reduce diversity and motion. Autoguidance mitigates these issues…

Computer Vision and Pattern Recognition · Computer Science 2024-12-02 Junha Hyung , Kinam Kim , Susung Hong , Min-Jung Kim , Jaegul Choo

Spatial-temporal graph representations play a crucial role in urban sensing applications, including traffic analysis, human mobility behavior modeling, and citywide crime prediction. However, a key challenge lies in the noisy and sparse…

Machine Learning · Computer Science 2025-08-15 Qianru Zhang , Xinyi Gao , Haixin Wang , Dong Huang , Siu-Ming Yiu , Hongzhi Yin

Spatial transcriptomics enables simultaneous measurement of gene expression and tissue morphology, offering unprecedented insights into cellular organization and disease mechanisms. However, the field lacks comprehensive benchmarks for…