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Related papers: Enhancing SHAP Explainability for Diagnostic and P…

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Reinforcement learning (RL) has recently shown promise in predicting Alzheimer's disease (AD) progression due to its unique ability to model domain knowledge. However, it is not clear which RL algorithms are well-suited for this task.…

In this growing age of data and technology, large black-box models are becoming the norm due to their ability to handle vast amounts of data and learn incredibly complex input-output relationships. The deficiency of these methods, however,…

Machine Learning · Computer Science 2025-10-13 Justin Lin , Julia Fukuyama

An interpretable machine learning (ML) framework is introduced to enhance the diagnosis of Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) by ensuring robustness of the ML models' interpretations. The dataset used comprises…

Early and accurate detection of Alzheimer's disease (AD) remains a major challenge in medical diagnosis due to its subtle onset and progressive nature. This research introduces an explainable ensemble learning Framework designed to classify…

Machine Learning · Computer Science 2026-03-06 Nishan Mitra

Understanding the distinction between causation and correlation is critical in Alzheimer's disease (AD) research, as it impacts diagnosis, treatment, and the identification of true disease drivers. This experiment investigates the…

Artificial Intelligence · Computer Science 2025-06-13 Hamzah Dabool , Raghad Mustafa

In this growing age of data and technology, large black-box models are becoming the norm due to their ability to handle vast amounts of data and learn incredibly complex data patterns. The deficiency of these methods, however, is their…

Machine Learning · Computer Science 2026-04-09 Justin Lin , Julia Fukuyama

When using machine learning techniques in decision-making processes, the interpretability of the models is important. In the present paper, we adopted the Shapley additive explanation (SHAP), which is based on fair profit allocation among…

Machine Learning · Computer Science 2022-03-03 Yasunobu Nohara , Koutarou Matsumoto , Hidehisa Soejima , Naoki Nakashima

Explaining machine learning (ML) predictions has become crucial as ML models are increasingly deployed in high-stakes domains such as healthcare. While SHapley Additive exPlanations (SHAP) is widely used for model interpretability, it fails…

Machine Learning · Computer Science 2025-09-03 Woon Yee Ng , Li Rong Wang , Siyuan Liu , Xiuyi Fan

Integrating heterogeneous biomedical data including imaging, omics, and clinical records supports accurate diagnosis and personalised care. Graph-based models fuse such non-Euclidean data by capturing spatial and relational structure, yet…

Genomics · Quantitative Biology 2025-05-06 Alireza Sadeghi , Farshid Hajati , Ahmadreza Argha , Nigel H Lovell , Min Yang , Hamid Alinejad-Rokny

Understanding why a model makes a certain prediction can be as crucial as the prediction's accuracy in many applications. However, the highest accuracy for large modern datasets is often achieved by complex models that even experts struggle…

Artificial Intelligence · Computer Science 2017-11-28 Scott Lundberg , Su-In Lee

Machine learning methods have shown large potential for the automatic early diagnosis of Alzheimer's Disease (AD). However, some machine learning methods based on imaging data have poor interpretability because it is usually unclear how…

Post-hoc explanations are widely used to justify, contest, and review automated decisions in high-stakes domains such as lending, employment, and healthcare. Among these methods, SHAP is often treated as providing a reliable account of…

Machine Learning · Computer Science 2026-01-27 Hyunseung Hwang , Seungeun Lee , Lucas Rosenblatt , Steven Euijong Whang , Julia Stoyanovich

Explaining machine learning (ML) models using eXplainable AI (XAI) techniques has become essential to make them more transparent and trustworthy. This is especially important in high-stakes domains like healthcare, where understanding model…

Machine Learning · Computer Science 2025-12-04 Felix Tempel , Daniel Groos , Espen Alexander F. Ihlen , Lars Adde , Inga Strümke

Model interpretability is crucial for understanding and trusting the decisions made by complex machine learning models, such as those built with XGBoost. SHAP (SHapley Additive exPlanations) values have become a popular tool for…

Human-Computer Interaction · Computer Science 2026-03-04 Xianlong Zeng , Kewen Zhu

Machine and deep learning have grown in popularity and use in biological research over the last decade but still present challenges in interpretability of the fitted model. The development and use of metrics to determine features driving…

Machine Learning · Statistics 2025-07-31 Daniel Claborne , Javier Flores , Samantha Erwin , Luke Durell , Rachel Richardson , Ruby Fore , Lisa Bramer

Alzheimer's disease (AD) is a progressive and irreversible brain disorder that unfolds over the course of 30 years. Therefore, it is critical to capture the disease progression in an early stage such that intervention can be applied before…

Machine Learning · Computer Science 2024-09-02 Yipei Wang , Bing He , Shannon Risacher , Andrew Saykin , Jingwen Yan , Xiaoqian Wang

Interpretability remains a key challenge for deploying large language models (LLMs) in clinical settings such as Alzheimer's disease progression diagnosis, where early and trustworthy predictions are essential. Existing attribution methods…

Machine learning (ML) for transient stability assessment has gained traction due to the significant increase in computational requirements as renewables connect to power systems. To achieve a high degree of accuracy; black-box ML models are…

Systems and Control · Electrical Eng. & Systems 2023-02-14 Robert I. Hamilton , Panagiotis N. Papadopoulos

Objective. Type 2 diabetes mellitus (T2DM) is a highly prevalent non-communicable chronic disease that substantially reduces life expectancy. Accurate estimation of all-cause mortality risk in T2DM patients is crucial for personalizing and…

Diagnosing Alzheimer's disease (AD) involves a deliberate diagnostic process owing to its innate traits of irreversibility with subtle and gradual progression. These characteristics make AD biomarker identification from structural brain…

Machine Learning · Computer Science 2022-07-28 Ahmad Wisnu Mulyadi , Wonsik Jung , Kwanseok Oh , Jee Seok Yoon , Heung-Il Suk
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