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Current protein language models (PLMs) learn protein representations mainly based on their sequences, thereby well capturing co-evolutionary information, but they are unable to explicitly acquire protein functions, which is the end goal of…

Biomolecules · Quantitative Biology 2023-07-06 Minghao Xu , Xinyu Yuan , Santiago Miret , Jian Tang

Although Vision Language Models (VLMs) exhibit strong perceptual abilities and impressive visual reasoning, they struggle with attention to detail and precise action planning in complex, dynamic environments, leading to subpar performance.…

Artificial Intelligence · Computer Science 2025-08-08 Xinrun Xu , Pi Bu , Ye Wang , Börje F. Karlsson , Ziming Wang , Tengtao Song , Qi Zhu , Jun Song , Zhiming Ding , Bo Zheng

Attention-based models trained on protein sequences have demonstrated incredible success at classification and generation tasks relevant for artificial intelligence-driven protein design. However, we lack a sufficient understanding of how…

Machine Learning · Computer Science 2022-06-29 Erik Nijkamp , Jeffrey Ruffolo , Eli N. Weinstein , Nikhil Naik , Ali Madani

Clinical reasoning in medicine is a hypothesis-driven process where physicians refine diagnoses from limited information through targeted history, physical examination, and diagnostic investigations. In contrast, current medical benchmarks…

Machine Learning · Computer Science 2025-10-14 Christopher Chiu , Silviu Pitis , Mihaela van der Schaar

Recent advances in vision-language models (VLMs) have achieved remarkable performance on standard medical benchmarks, yet their true clinical reasoning ability remains unclear. Existing datasets predominantly emphasize classification…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Miao Jing , Mengting Jia , Junling Lin , Zhongxia Shen , Huan Gao , Mingkun Xu , Shangyang Li

Stock prediction, a subject closely related to people's investment activities in fully dynamic and live environments, has been widely studied. Current large language models (LLMs) have shown remarkable potential in various domains,…

Statistical Finance · Quantitative Finance 2026-01-13 Bohan Liang , Zijian Chen , Qi Jia , Kaiwei Zhang , Kaiyuan Ji , Guangtao Zhai

Performance prediction is a method to estimate the performance of Language Models (LMs) on various Natural Language Processing (NLP) tasks, mitigating computational costs associated with model capacity and data for fine-tuning. Our paper…

Computation and Language · Computer Science 2024-12-17 David Anugraha , Genta Indra Winata , Chenyue Li , Patrick Amadeus Irawan , En-Shiun Annie Lee

As generative AI continues to evolve, Vision Language Models (VLMs) have emerged as promising tools in various healthcare applications. One area that remains relatively underexplored is their use in human activity recognition (HAR) for…

Computation and Language · Computer Science 2025-11-18 Abderrazek Abid , Thanh-Cong Ho , Fakhri Karray

Large Language Models (LLMs) achieve competitive results compared to human experts in medical examinations. However, it remains a challenge to apply LLMs to complex clinical decision-making, which requires a deep understanding of medical…

Multimodal LLMs (MLLMs) are capable of performing complex data analysis, visual question answering, generation, and reasoning tasks. However, their ability to analyze biometric data is relatively underexplored. In this work, we investigate…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Ekta Gavas , Sudipta Banerjee , Chinmay Hegde , Nasir Memon

Vision-language models (VLMs) achieve strong benchmark results, yet can exhibit systematic perceptual weaknesses: structured, large changes to pixel values can cause confident yet nonsensical predictions, even when the underlying scene…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Nicoleta-Nina Basoc , Adrian Cosma , Emilian Radoi

Several recent works seek to adapt general-purpose large language models (LLMs) and vision-language models (VLMs) for medical applications through continued pretraining on publicly available biomedical corpora. These works typically claim…

Computation and Language · Computer Science 2025-07-01 Daniel P. Jeong , Pranav Mani , Saurabh Garg , Zachary C. Lipton , Michael Oberst

Ultrasound is a widely-used imaging modality critical to global healthcare, yet its interpretation remains challenging due to its varying image quality on operators, noises, and anatomical structures. Although large vision-language models…

Predicting enzymatic reactions is crucial for applications in biocatalysis, metabolic engineering, and drug discovery, yet it remains a complex and resource-intensive task. Large Language Models (LLMs) have recently demonstrated remarkable…

Artificial Intelligence · Computer Science 2025-05-12 Lorenzo Di Fruscia , Jana Marie Weber

Vision-language models (VLMs) have made significant progress in recent visual-question-answering (VQA) benchmarks that evaluate complex visio-linguistic reasoning. However, are these models truly effective? In this work, we show that VLMs…

Computer Vision and Pattern Recognition · Computer Science 2025-06-11 Baiqi Li , Zhiqiu Lin , Wenxuan Peng , Jean de Dieu Nyandwi , Daniel Jiang , Zixian Ma , Simran Khanuja , Ranjay Krishna , Graham Neubig , Deva Ramanan

This paper introduces PhyloLM, a method adapting phylogenetic algorithms to Large Language Models (LLMs) to explore whether and how they relate to each other and to predict their performance characteristics. Our method calculates a…

Computation and Language · Computer Science 2025-12-09 Nicolas Yax , Pierre-Yves Oudeyer , Stefano Palminteri

There is widespread optimism that frontier Large Language Models (LLMs) and LLM-augmented systems have the potential to rapidly accelerate scientific discovery across disciplines. Today, many benchmarks exist to measure LLM knowledge and…

As language models (LMs) become increasingly powerful and widely used, it is important to quantify them for sociodemographic bias with potential for harm. Prior measures of bias are sensitive to perturbations in the templates designed to…

Computation and Language · Computer Science 2024-08-09 Vipul Gupta , Pranav Narayanan Venkit , Hugo Laurençon , Shomir Wilson , Rebecca J. Passonneau

Large Vision-Language Models (LVLMs) are capable of handling diverse data types such as imaging, text, and physiological signals, and can be applied in various fields. In the medical field, LVLMs have a high potential to offer substantial…

Students' handwritten math work provides a rich resource for diagnosing cognitive skills, as it captures intermediate reasoning beyond final answers. We investigate how current large language models (LLMs) perform in diagnosing cognitive…

Artificial Intelligence · Computer Science 2026-02-05 Yoonsu Kim , Hyoungwook Jin , Hayeon Doh , Eunhye Kim , Dongyun Jung , Seungju Kim , Kiyoon Choi , Jinho Son , Juho Kim