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Cluster-randomized trials (CRTs) are widely used to evaluate group-level interventions and increasingly collect multiple outcomes capturing complementary dimensions of benefit and risk. Investigators often seek a single global summary of…

Methodology · Statistics 2026-01-22 Xinyuan Chen , Fan Li

Clustering aims to group unlabelled samples based on their similarities. It has become a significant tool for the analysis of high-dimensional data. However, most of the clustering methods merely generate pseudo labels and thus are unable…

Artificial Intelligence · Computer Science 2023-06-21 Tianyi Huang , Shenghui Cheng , Stan Z. Li , Zhengjun Zhang

Personalized medicine, a paradigm of medicine tailored to a patient's characteristics, is an increasingly attractive field in health care. An important goal of personalized medicine is to identify a subgroup of patients, based on baseline…

Machine Learning · Statistics 2023-01-31 Hengrui Cai , Wenbin Lu , Rachel Marceau West , Devan V. Mehrotra , Lingkang Huang

Many high-stakes decisions in health care, public policy, and clinical development require committing to a single policy that will be applied uniformly across a heterogeneous population. Regulatory and fairness standards sometime requires…

Machine Learning · Computer Science 2026-05-12 Tingyu Zhu , Yuhang Wu , Zeyu Zheng

Mixture model-based frameworks are very popular for statistical inference in clustering. While convenient for producing probabilistic estimates of cluster assignments and uncertainty, they are prone to misspecification, which can lead to…

Statistics Theory · Mathematics 2026-05-15 Yu Zheng , Leo L. Duan , Arkaprava Roy

In this thesis, we propose several modelling strategies to tackle evolving data in different contexts. In the framework of static clustering, we start by introducing a soft kernel spectral clustering (SKSC) algorithm, which can better deal…

Social and Information Networks · Computer Science 2014-11-24 Rocco Langone

Causal effect estimation is important for many tasks in the natural and social sciences. We design algorithms for the continuous partial identification problem: bounding the effects of multivariate, continuous treatments when unmeasured…

Machine Learning · Statistics 2023-05-18 Kirtan Padh , Jakob Zeitler , David Watson , Matt Kusner , Ricardo Silva , Niki Kilbertus

The use of a finite mixture of normal distributions in model-based clustering allows to capture non-Gaussian data clusters. However, identifying the clusters from the normal components is challenging and in general either achieved by…

Methodology · Statistics 2016-06-21 Gertraud Malsiner-Walli , Sylvia Frühwirth-Schnatter , Bettina Grün

Selecting subsets of features that differentiate between two conditions is a key task in a broad range of scientific domains. In many applications, the features of interest form clusters with similar effects on the data at hand. To recover…

Machine Learning · Computer Science 2022-11-11 Ram Dyuthi Sristi , Gal Mishne , Ariel Jaffe

Clustering algorithms rely on complex optimisation processes that may be difficult to comprehend, especially for individuals who lack technical expertise. While many explainable artificial intelligence techniques exist for supervised…

Machine Learning · Computer Science 2024-09-20 Aurora Spagnol , Kacper Sokol , Pietro Barbiero , Marc Langheinrich , Martin Gjoreski

Currently, data-driven discovery in biological sciences resides in finding segmentation strategies in multivariate data that produce sensible descriptions of the data. Clustering is but one of several approaches and sometimes falls short…

Quantitative Methods · Quantitative Biology 2022-08-12 Richard Tjörnhammar

In this paper we study the problems of estimating heterogeneity in causal effects in experimental or observational studies and conducting inference about the magnitude of the differences in treatment effects across subsets of the…

Machine Learning · Statistics 2022-06-08 Susan Athey , Guido Imbens

Clustering is ubiquitous in data analysis, including analysis of time series. It is inherently subjective: different users may prefer different clusterings for a particular dataset. Semi-supervised clustering addresses this by allowing the…

Machine Learning · Statistics 2018-05-03 Toon Van Craenendonck , Wannes Meert , Sebastijan Dumancic , Hendrik Blockeel

In this work, we propose an original method for aggregating multiple clustering coming from different sources of information. Each partition is encoded by a co-membership matrix between observations. Our approach uses a mixture of…

Machine Learning · Computer Science 2024-01-10 Kylliann De Santiago , Marie Szafranski , Christophe Ambroise

In this paper we present a method for the unsupervised clustering of high-dimensional binary data, with a special focus on electronic healthcare records. We present a robust and efficient heuristic to face this problem using tensor…

Machine Learning · Statistics 2017-08-31 Matteo Ruffini , Ricard Gavaldà , Esther Limón

Cancer has become one of the most widespread diseases in the world. Specifically, breast cancer is diagnosed more often than any other type of cancer. However, breast cancer patients and their individual tumors are often unique. Identifying…

Quantitative Methods · Quantitative Biology 2016-12-06 Chenzhe Qian

Subspace clustering (SC) is a promising clustering technology to identify clusters based on their associations with subspaces in high dimensional spaces. SC can be classified into hard subspace clustering (HSC) and soft subspace clustering…

Machine Learning · Computer Science 2016-04-11 Zhaohong Deng , Kup-Sze Choi , Yizhang Jiang , Jun Wang , Shitong Wang

Unsupervised clustering aims at discovering the semantic categories of data according to some distance measured in the representation space. However, different categories often overlap with each other in the representation space at the…

Machine Learning · Computer Science 2021-06-01 Dejiao Zhang , Feng Nan , Xiaokai Wei , Shangwen Li , Henghui Zhu , Kathleen McKeown , Ramesh Nallapati , Andrew Arnold , Bing Xiang

Recent years have witnessed many successful applications of contrastive learning in diverse domains, yet its self-supervised version still remains many exciting challenges. As the negative samples are drawn from unlabeled datasets, a…

Machine Learning · Computer Science 2024-02-01 Bin Liu , Bang Wang , Tianrui Li

We consider comparisons of statistical learning algorithms using multiple data sets, via leave-one-in cross-study validation: each of the algorithms is trained on one data set; the resulting model is then validated on each remaining data…

Applications · Statistics 2015-06-02 Lorenzo Trippa , Levi Waldron , Curtis Huttenhower , Giovanni Parmigiani