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Large language models (LLMs) can simulate clinical reasoning based on natural language prompts, but their utility in ophthalmology is largely unexplored. This study evaluated GPT-4's ability to interpret structured textual descriptions of…

Computation and Language · Computer Science 2025-07-03 Cindy Lie Tabuse , David Restepo , Carolina Gracitelli , Fernando Korn Malerbi , Caio Regatieri , Luis Filipe Nakayama

Large language models perform well on many medical QA benchmarks, but real clinical reasoning often requires integrating evidence across multiple images rather than interpreting a single view. We introduce MedThinkVQA, an expert-annotated…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Zonghai Yao , Benlu Wang , Yifan Zhang , Junda Wang , Iris Xia , Zhipeng Tang , Shuo Han , Feiyun Ouyang , Zhichao Yang , Arman Cohan , Hong Yu

This is the system card published alongside the OpenAI GPT-5 launch, August 2025. GPT-5 is a unified system with a smart and fast model that answers most questions, a deeper reasoning model for harder problems, and a real-time router that…

Computation and Language · Computer Science 2026-05-05 Aaditya Singh , Adam Fry , Adam Perelman , Adam Tart , Adi Ganesh , Ahmed El-Kishky , Aidan McLaughlin , Aiden Low , AJ Ostrow , Akhila Ananthram , Akshay Nathan , Alan Luo , Alec Helyar , Aleksander Madry , Aleksandr Efremov , Aleksandra Spyra , Alex Baker-Whitcomb , Alex Beutel , Alex Karpenko , Alex Makelov , Alex Neitz , Alex Wei , Alexandra Barr , Alexandre Kirchmeyer , Alexey Ivanov , Alexi Christakis , Alistair Gillespie , Allison Tam , Ally Bennett , Alvin Wan , Alyssa Huang , Amy McDonald Sandjideh , Amy Yang , Ananya Kumar , Andre Saraiva , Andrea Vallone , Andrei Gheorghe , Andres Garcia Garcia , Andrew Braunstein , Andrew Liu , Andrew Schmidt , Andrey Mereskin , Andrey Mishchenko , Andy Applebaum , Andy Rogerson , Ann Rajan , Annie Wei , Anoop Kotha , Anubha Srivastava , Anushree Agrawal , Arun Vijayvergiya , Ashley Tyra , Ashvin Nair , Avi Nayak , Ben Eggers , Bessie Ji , Beth Hoover , Bill Chen , Blair Chen , Boaz Barak , Borys Minaiev , Botao Hao , Bowen Baker , Brad Lightcap , Brandon McKinzie , Brandon Wang , Brendan Quinn , Brian Fioca , Brian Hsu , Brian Yang , Brian Yu , Brian Zhang , Brittany Brenner , Callie Riggins Zetino , Cameron Raymond , Camillo Lugaresi , Carolina Paz , Cary Hudson , Cedric Whitney , Chak Li , Charles Chen , Charlotte Cole , Chelsea Voss , Chen Ding , Chen Shen , Chengdu Huang , Chris Colby , Chris Hallacy , Chris Koch , Chris Lu , Christina Kaplan , Christina Kim , CJ Minott-Henriques , Cliff Frey , Cody Yu , Coley Czarnecki , Colin Reid , Colin Wei , Cory Decareaux , Cristina Scheau , Cyril Zhang , Cyrus Forbes , Da Tang , Dakota Goldberg , Dan Roberts , Dana Palmie , Daniel Kappler , Daniel Levine , Daniel Wright , Dave Leo , David Lin , David Robinson , Declan Grabb , Derek Chen , Derek Lim , Derek Salama , Dibya Bhattacharjee , Dimitris Tsipras , Dinghua Li , Dingli Yu , DJ Strouse , Drew Williams , Dylan Hunn , Ed Bayes , Edwin Arbus , Ekin Akyurek , Elaine Ya Le , Elana Widmann , Eli Yani , Elizabeth Proehl , Enis Sert , Enoch Cheung , Eri Schwartz , Eric Han , Eric Jiang , Eric Mitchell , Eric Sigler , Eric Wallace , Erik Ritter , Erin Kavanaugh , Evan Mays , Evgenii Nikishin , Fangyuan Li , Felipe Petroski Such , Filipe de Avila Belbute Peres , Filippo Raso , Florent Bekerman , Foivos Tsimpourlas , Fotis Chantzis , Francis Song , Francis Zhang , Gaby Raila , Garrett McGrath , Gary Briggs , Gary Yang , Giambattista Parascandolo , Gildas Chabot , Grace Kim , Grace Zhao , Gregory Valiant , Guillaume Leclerc , Hadi Salman , Hanson Wang , Hao Sheng , Haoming Jiang , Haoyu Wang , Haozhun Jin , Harshit Sikchi , Heather Schmidt , Henry Aspegren , Honglin Chen , Huida Qiu , Hunter Lightman , Ian Covert , Ian Kivlichan , Ian Silber , Ian Sohl , Ibrahim Hammoud , Ignasi Clavera , Ikai Lan , Ilge Akkaya , Ilya Kostrikov , Irina Kofman , Isak Etinger , Ishaan Singal , Jackie Hehir , Jacob Huh , Jacqueline Pan , Jake Wilczynski , Jakub Pachocki , James Lee , James Quinn , Jamie Kiros , Janvi Kalra , Jasmyn Samaroo , Jason Wang , Jason Wolfe , Jay Chen , Jay Wang , Jean Harb , Jeffrey Han , Jeffrey Wang , Jennifer Zhao , Jeremy Chen , Jerene Yang , Jerry Tworek , Jesse Chand , Jessica Landon , Jessica Liang , Ji Lin , Jiancheng Liu , Jianfeng Wang , Jie Tang , Jihan Yin , Joanne Jang , Joel Morris , Joey Flynn , Johannes Ferstad , Johannes Heidecke , John Fishbein , John Hallman , Jonah Grant , Jonathan Chien , Jonathan Gordon , Jongsoo Park , Jordan Liss , Jos Kraaijeveld , Joseph Guay , Joseph Mo , Josh Lawson , Josh McGrath , Joshua Vendrow , Joy Jiao , Julian Lee , Julie Steele , Julie Wang , Junhua Mao , Kai Chen , Kai Hayashi , Kai Xiao , Kamyar Salahi , Kan Wu , Karan Sekhri , Karan Sharma , Karan Singhal , Karen Li , Kenny Nguyen , Keren Gu-Lemberg , Kevin King , Kevin Liu , Kevin Stone , Kevin Yu , Kristen Ying , Kristian Georgiev , Kristie Lim , Kushal Tirumala , Kyle Miller , Lama Ahmad , Larry Lv , Laura Clare , Laurance Fauconnet , Lauren Itow , Lauren Yang , Laurentia Romaniuk , Leah Anise , Lee Byron , Leher Pathak , Leon Maksin , Leyan Lo , Leyton Ho , Li Jing , Liang Wu , Liang Xiong , Lien Mamitsuka , Lin Yang , Lindsay McCallum , Lindsey Held , Liz Bourgeois , Logan Engstrom , Lorenz Kuhn , Louis Feuvrier , Lu Zhang , Lucas Switzer , Lukas Kondraciuk , Lukasz Kaiser , Manas Joglekar , Mandeep Singh , Mandip Shah , Manuka Stratta , Marcus Williams , Mark Chen , Mark Sun , Marselus Cayton , Martin Li , Marvin Zhang , Marwan Aljubeh , Matt Nichols , Matthew Haines , Max Schwarzer , Mayank Gupta , Meghan Shah , Melody Y. Guan , Melody Huang , Meng Dong , Mengqing Wang , Mia Glaese , Micah Carroll , Michael Lampe , Michael Malek , Michael Sharman , Michael Zhang , Michele Wang , Michelle Pokrass , Mihai Florian , Mikhail Pavlov , Miles Wang , Ming Chen , Mingxuan Wang , Minnia Feng , Mo Bavarian , Molly Lin , Moose Abdool , Mostafa Rohaninejad , Nacho Soto , Natalie Staudacher , Natan LaFontaine , Nathan Marwell , Nelson Liu , Nick Preston , Nick Turley , Nicklas Ansman , Nicole Blades , Nikil Pancha , Nikita Mikhaylin , Niko Felix , Nikunj Handa , Nishant Rai , Nitish Keskar , Noam Brown , Ofir Nachum , Oleg Boiko , Oleg Murk , Olivia Watkins , Oona Gleeson , Pamela Mishkin , Patryk Lesiewicz , Paul Baltescu , Pavel Belov , Peter Zhokhov , Philip Pronin , Phillip Guo , Phoebe Thacker , Qi Liu , Qiming Yuan , Qinghua Liu , Rachel Dias , Rachel Puckett , Rahul Arora , Ravi Teja Mullapudi , Raz Gaon , Reah Miyara , Rennie Song , Rishabh Aggarwal , RJ Marsan , Robel Yemiru , Robert Xiong , Rohan Kshirsagar , Rohan Nuttall , Roman Tsiupa , Ronen Eldan , Rose Wang , Roshan James , Roy Ziv , Rui Shu , Ruslan Nigmatullin , Saachi Jain , Saam Talaie , Sam Altman , Sam Arnesen , Sam Toizer , Sam Toyer , Samuel Miserendino , Sandhini Agarwal , Sarah Yoo , Savannah Heon , Scott Ethersmith , Sean Grove , Sean Taylor , Sebastien Bubeck , Sever Banesiu , Shaokyi Amdo , Shengjia Zhao , Sherwin Wu , Shibani Santurkar , Shiyu Zhao , Shraman Ray Chaudhuri , Shreyas Krishnaswamy , Shuaiqi , Xia , Shuyang Cheng , Shyamal Anadkat , Simón Posada Fishman , Simon Tobin , Siyuan Fu , Somay Jain , Song Mei , Sonya Egoian , Spencer Kim , Spug Golden , SQ Mah , Steph Lin , Stephen Imm , Steve Sharpe , Steve Yadlowsky , Sulman Choudhry , Sungwon Eum , Suvansh Sanjeev , Tabarak Khan , Tal Stramer , Tao Wang , Tao Xin , Tarun Gogineni , Taya Christianson , Ted Sanders , Tejal Patwardhan , Thomas Degry , Thomas Shadwell , Tianfu Fu , Tianshi Gao , Timur Garipov , Tina Sriskandarajah , Toki Sherbakov , Tomek Korbak , Tomer Kaftan , Tomo Hiratsuka , Tongzhou Wang , Tony Song , Tony Zhao , Troy Peterson , Val Kharitonov , Victoria Chernova , Vineet Kosaraju , Vishal Kuo , Vitchyr Pong , Vivek Verma , Vlad Petrov , Wanning Jiang , Weixing Zhang , Wenda Zhou , Wenlei Xie , Wenting Zhan , Wes McCabe , Will DePue , Will Ellsworth , Wulfie Bain , Wyatt Thompson , Xiangning Chen , Xiangyu Qi , Xin Xiang , Xinwei Shi , Yann Dubois , Yaodong Yu , Yara Khakbaz , Yifan Wu , Yilei Qian , Yin Tat Lee , Yinbo Chen , Yizhen Zhang , Yizhong Xiong , Yonglong Tian , Young Cha , Yu Bai , Yu Yang , Yuan Yuan , Yuanzhi Li , Yufeng Zhang , Yuguang Yang , Yujia Jin , Yun Jiang , Yunyun Wang , Yushi Wang , Yutian Liu , Zach Stubenvoll , Zehao Dou , Zheng Wu , Zhigang Wang

Diabetes mellitus is a major global health challenge, affecting over half a billion adults worldwide with prevalence projected to rise. Although the American Diabetes Association (ADA) provides clear diagnostic thresholds, early recognition…

Computation and Language · Computer Science 2025-09-29 Gaurav Kumar Gupta , Nirajan Acharya , Pranal Pande

The advent of large language models (LLMs) has heightened interest in their potential for multimodal applications that integrate language and vision. This paper explores the capabilities of GPT-4V in the realms of geography, environmental…

Computer Vision and Pattern Recognition · Computer Science 2023-12-29 Chenjiao Tan , Qian Cao , Yiwei Li , Jielu Zhang , Xiao Yang , Huaqin Zhao , Zihao Wu , Zhengliang Liu , Hao Yang , Nemin Wu , Tao Tang , Xinyue Ye , Lilong Chai , Ninghao Liu , Changying Li , Lan Mu , Tianming Liu , Gengchen Mai

The increasing availability of unstructured clinical narratives in electronic health records (EHRs) has created new opportunities for automated disease characterization, cohort identification, and clinical decision support. However,…

Computation and Language · Computer Science 2026-03-03 Fariba Afrin Irany , Sampson Akwafuo

Multilingual capability is an essential aspect for large multimodal models, since they are usually deployed across various countries and languages. However, most existing benchmarks for multilingual multimodal reasoning struggle to…

Computer Vision and Pattern Recognition · Computer Science 2025-04-28 Hongyu Wang , Jiayu Xu , Senwei Xie , Ruiping Wang , Jialin Li , Zhaojie Xie , Bin Zhang , Chuyan Xiong , Xilin Chen

Many real-world tasks require an agent to reason jointly over text and visual objects, (e.g., navigating in public spaces), which we refer to as context-sensitive text-rich visual reasoning. Specifically, these tasks require an…

Computer Vision and Pattern Recognition · Computer Science 2024-07-30 Rohan Wadhawan , Hritik Bansal , Kai-Wei Chang , Nanyun Peng

Recent announcements from frontier AI model labs have highlighted strong results on high-school and undergraduate math competitions. Yet it remains unclear whether large language models can solve new, simple conjectures in more advanced…

Artificial Intelligence · Computer Science 2025-09-24 Moran Feldman , Amin Karbasi

A central question in artificial intelligence is the extent to which machine learning models comprehend mathematics. To address this, we propose a novel framework for measuring mathematical reasoning that moves beyond standard benchmarks to…

Computation and Language · Computer Science 2025-10-13 V. S. Raghu Parupudi

Recent advancements in artificial intelligence (AI) have precipitated significant breakthroughs in healthcare, particularly in refining diagnostic procedures. However, previous studies have often been constrained to limited functionalities.…

Artificial Intelligence · Computer Science 2024-07-08 Asma Alkhaldi , Raneem Alnajim , Layan Alabdullatef , Rawan Alyahya , Jun Chen , Deyao Zhu , Ahmed Alsinan , Mohamed Elhoseiny

Artificial intelligence (AI) researchers have been developing and refining large language models (LLMs) that exhibit remarkable capabilities across a variety of domains and tasks, challenging our understanding of learning and cognition. The…

The rapid development of language-based artificial intelligence (AI) offers new possibilities for psychotherapy and assistive systems, particularly benefitting autistic individuals who often respond well to technology. Parents of autistic…

Clinical document classification is essential for converting unstructured medical texts into standardised ICD-10 diagnoses, yet it faces challenges due to complex medical language, privacy constraints, and limited annotated datasets. Large…

Computation and Language · Computer Science 2026-02-03 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

Large multimodal models extend the impressive capabilities of large language models by integrating multimodal understanding abilities. However, it is not clear how they can emulate the general intelligence and reasoning ability of humans.…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Yew Ken Chia , Vernon Toh Yan Han , Deepanway Ghosal , Lidong Bing , Soujanya Poria

Large language models, particularly GPT-3, are able to produce high quality summaries of general domain news articles in few- and zero-shot settings. However, it is unclear if such models are similarly capable in more specialized,…

Computation and Language · Computer Science 2023-05-12 Chantal Shaib , Millicent L. Li , Sebastian Joseph , Iain J. Marshall , Junyi Jessy Li , Byron C. Wallace

This study evaluates the GPT-4 Large Language Model's abductive reasoning in complex fields like medical diagnostics, criminology, and cosmology. Using an interactive interview format, the AI assistant demonstrated reliability in generating…

Artificial Intelligence · Computer Science 2023-07-21 Remo Pareschi

The rapid expansion of electronic health record (EHR) systems has generated large volumes of unstructured clinical narratives that contain valuable information for disease identification, patient cohort discovery, and clinical decision…

Computation and Language · Computer Science 2026-03-17 Fariba Afrin Irany , Sampson Akwafuo

Traditional biomedical artificial intelligence (AI) models, designed for specific tasks or modalities, often exhibit limited flexibility in real-world deployment and struggle to utilize holistic information. Generalist AI holds the…

Chain-of-Thought (CoT) reasoning has proven effective in enhancing large language models by encouraging step-by-step intermediate reasoning, and recent advances have extended this paradigm to Multimodal Large Language Models (MLLMs). In the…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Juntao Jiang , Jiangning Zhang , Yali Bi , Jinsheng Bai , Weixuan Liu , Weiwei Jin , Zhucun Xue , Yong Liu , Xiaobin Hu , Shuicheng Yan