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Protein representation learning is critical for numerous biological tasks. Recently, large transformer-based protein language models (pLMs) pretrained on large scale protein sequences have demonstrated significant success in sequence-based…

Machine Learning · Computer Science 2025-08-12 Xuefeng Liu , Songhao Jiang , Chih-chan Tien , Jinbo Xu , Rick Stevens

Despite its notable success in adversarial learning approaches to multi-domain task-oriented dialog system, training the dialog policy via adversarial inverse reinforcement learning often fails to balance the performance of the policy…

Artificial Intelligence · Computer Science 2020-06-02 Jeiyoon Park , Chanhee Lee , Kuekyeng Kim , Heuiseok Lim

The Vehicle Routing Problem (VRP) is a complex optimization problem with numerous real-world applications, mostly solved using metaheuristic algorithms due to its $\mathcal{NP}$-Hard nature. Traditionally, these metaheuristics rely on…

Artificial Intelligence · Computer Science 2025-08-11 Bachtiar Herdianto , Romain Billot , Flavien Lucas , Marc Sevaux

Mixed communities of organisms are found in many environments (from the human gut to marine ecosystems) and can have profound impact on human health and the environment. Metagenomics studies the genomic material of such communities through…

Genomics · Quantitative Biology 2021-12-23 Hansheng Xue , Vijini Mallawaarachchi , Yujia Zhang , Vaibhav Rajan , Yu Lin

The score-based structure learning of Bayesian network (BN) is an effective way to learn BN models, which are regarded as some of the most compelling probabilistic graphical models in the field of representation and reasoning under…

Machine Learning · Computer Science 2025-04-08 Mingcan Wang , Junchang Xin , Luxuan Qu , Qi Chen , Zhiqiong Wang

Signaling proteins are an important topic in drug development due to the increased importance of finding fast, accurate and cheap methods to evaluate new molecular targets involved in specific diseases. The complexity of the protein…

Quantitative Methods · Quantitative Biology 2019-04-11 Carlos Fernandez-Lozano , Ruben F. Cuinas , Jose A. Seoane , Enrique Fernandez-Blanco , Julian Dorado , Cristian R. Munteanu

Salient object detection requires a comprehensive and scalable receptive field to locate the visually significant objects in the image. Recently, the emergence of visual transformers and multi-branch modules has significantly enhanced the…

Computer Vision and Pattern Recognition · Computer Science 2021-10-18 Mingcan Ma , Changqun Xia , Chenxi Xie , Xiaowu Chen , Jia Li

Restless Multi-Armed Bandits (RMABs) are a powerful framework for sequential decision-making, widely applied in resource allocation and intervention optimization challenges in public health. However, traditional RMABs assume independence…

Machine Learning · Computer Science 2025-12-09 Hanmo Zhang , Zenghui Sun , Kai Wang

Discovering relational structure between input features in sequence labeling models has shown to improve their accuracy in several problem settings. However, the search space of relational features is exponential in the number of basic…

Machine Learning · Computer Science 2017-05-09 Naveen Nair , Ajay Nagesh , Ganesh Ramakrishnan

Packing objects efficiently is a fundamental problem in logistics, warehouse automation, and robotics. While traditional packing solutions focus on geometric optimization, packing irregular, 3D objects presents significant challenges due to…

The rapid expansion of remote sensing image archives demands the development of strong and efficient techniques for content-based image retrieval (RS-CBIR). This paper presents REJEPA (Retrieval with Joint-Embedding Predictive…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Shabnam Choudhury , Yash Salunkhe , Sarthak Mehrotra , Biplab Banerjee

Sequential decision making under uncertainty is central to many Process Systems Engineering (PSE) challenges, where traditional methods often face limitations related to controlling and optimizing complex and stochastic systems.…

Systems and Control · Electrical Eng. & Systems 2025-10-29 Maximilian Bloor , Max Mowbray , Ehecatl Antonio Del Rio Chanona , Calvin Tsay

In modern ML Ops environments, model deployment is a critical process that traditionally relies on static heuristics such as validation error comparisons and A/B testing. However, these methods require human intervention to adapt to…

Machine Learning · Computer Science 2025-03-31 S. Aaron McClendon , Vishaal Venkatesh , Juan Morinelli

Antibodies are essential proteins responsible for immune responses in organisms, capable of specifically recognizing antigen molecules of pathogens. Recent advances in generative models have significantly enhanced rational antibody design.…

Artificial Intelligence · Computer Science 2025-11-10 Zichen Wang , Yaokun Ji , Jianing Tian , Shuangjia Zheng

Accurate identification of antiviral peptides (AVPs) is critical for accelerating novel drug development. However, current computational methods struggle to capture intricate sequence dependencies and effectively handle ambiguous,…

Machine Learning · Computer Science 2025-12-29 Xinru Wen , Weizhong Lin , Xuan Xiao

Retrieval Augmented Generation (RAG) has proven to be highly effective in boosting the generative performance of language model in knowledge-intensive tasks. However, existing RAG framework either indiscriminately perform retrieval or rely…

Artificial Intelligence · Computer Science 2025-01-03 Xiaqiang Tang , Qiang Gao , Jian Li , Nan Du , Qi Li , Sihong Xie

The majority of machine learning methods and algorithms give high priority to prediction performance which may not always correspond to the priority of the users. In many cases, practitioners and researchers in different fields, going from…

Strong physical unclonable function (PUF) is a promising solution for device authentication in resourceconstrained applications but vulnerable to machine learning attacks. In order to resist such attack, many defenses have been proposed in…

Cryptography and Security · Computer Science 2019-11-14 Jiliang Zhang , Chaoqun Shen

We are now witnessing significant progress of deep learning methods in a variety of tasks (or datasets) of proteins. However, there is a lack of a standard benchmark to evaluate the performance of different methods, which hinders the…

Machine Learning · Computer Science 2022-09-20 Minghao Xu , Zuobai Zhang , Jiarui Lu , Zhaocheng Zhu , Yangtian Zhang , Chang Ma , Runcheng Liu , Jian Tang

An ongoing challenge in neuromorphic computing is to devise general and computationally efficient models of inference and learning which are compatible with the spatial and temporal constraints of the brain. One increasingly popular and…

Neural and Evolutionary Computing · Computer Science 2019-05-06 Emre Neftci , Charles Augustine , Somnath Paul , Georgios Detorakis