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Learning stochastic functions from partially observed context-target pairs requires models that are expressive, uncertainty-aware, and strongly conditioned on inputs. Neural Diffusion Processes (NDPs) improve expressivity with denoising…

Machine Learning · Computer Science 2026-04-30 Jian Xu , Yican Liu , Delu Zeng , John Paisley , Qibin Zhao

Recent advances in single cell sequencing and multi-omics techniques have significantly improved our understanding of biological phenomena and our capacity to model them. Despite combined capture of data modalities showing similar progress,…

Molecular Networks · Quantitative Biology 2025-03-13 Marcello Barylli , Joyaditya Saha , Tineke E. Buffart , Jan Koster , Kristiaan J. Lenos , Louis Vermeulen , Vivek M. Sheraton

Microscopy images from different imaging conditions, organs, and tissues often have numerous cells with various shapes on a range of backgrounds. As a result, designing a deep learning model to count cells in a source domain becomes…

Computer Vision and Pattern Recognition · Computer Science 2023-03-21 Zuhui Wang

For domains that involve numerical simulation, it can be computationally expensive to run an ensemble of simulations spanning a parameter space of interest to a user. To this end, an attractive surrogate for simulation is the generative…

Machine Learning · Computer Science 2025-05-13 Xiaohan Wang , Matthew Berger

In diffusion models, deviations from a straight generative flow are a common issue, resulting in semantic inconsistencies and suboptimal generations. To address this challenge, we introduce `Non-Cross Diffusion', an innovative approach in…

Machine Learning · Computer Science 2024-11-05 Ziyang Zheng , Ruiyuan Gao , Qiang Xu

Vector Quantized-Variational AutoEncoders (VQ-VAE) are generative models based on discrete latent representations of the data, where inputs are mapped to a finite set of learned embeddings.To generate new samples, an autoregressive prior…

Machine Learning · Statistics 2022-08-04 Max Cohen , Guillaume Quispe , Sylvain Le Corff , Charles Ollion , Eric Moulines

With a view to statistical inference for discretely observed diffusion models, we propose simple methods of simulating diffusion bridges, approximately and exactly. Diffusion bridge simulation plays a fundamental role in likelihood and…

Statistics Theory · Mathematics 2014-03-10 Mogens Bladt , Michael Sørensen

We propose a probabilistic model for interpreting gene expression levels that are observed through single-cell RNA sequencing. In the model, each cell has a low-dimensional latent representation. Additional latent variables account for…

Machine Learning · Computer Science 2018-01-18 Romain Lopez , Jeffrey Regier , Michael Cole , Michael Jordan , Nir Yosef

Diffusion bridge models establish probabilistic paths between arbitrary paired distributions and exhibit great potential for universal image restoration. Most existing methods merely treat them as simple variants of stochastic interpolants,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-04 Hebaixu Wang , Jing Zhang , Haoyang Chen , Haonan Guo , Di Wang , Jiayi Ma , Bo Du

Machine learning enables unbinned, highly-differential cross section measurements. A recent idea uses generative models to morph a starting simulation into the unfolded data. We show how to extend two morphing techniques, Schr\"odinger…

High Energy Physics - Phenomenology · Physics 2025-06-25 Anja Butter , Sascha Diefenbacher , Nathan Huetsch , Vinicius Mikuni , Benjamin Nachman , Sofia Palacios Schweitzer , Tilman Plehn

The diffusion bridge, which is a diffusion process conditioned on hitting a specific state within a finite period, has found broad applications in various scientific and engineering fields. However, simulating diffusion bridges for modeling…

Machine Learning · Computer Science 2025-05-02 Gefan Yang , Elizabeth Louise Baker , Michael L. Severinsen , Christy Anna Hipsley , Stefan Sommer

Diffusion-based generative models learn to iteratively transfer unstructured noise to a complex target distribution as opposed to Generative Adversarial Networks (GANs) or the decoder of Variational Autoencoders (VAEs) which produce samples…

Machine Learning · Computer Science 2022-10-26 Sarthak Mittal , Guillaume Lajoie , Stefan Bauer , Arash Mehrjou

Despite the unprecedented success of text-to-image diffusion models, controlling the number of depicted objects using text is surprisingly hard. This is important for various applications from technical documents, to children's books to…

Computer Vision and Pattern Recognition · Computer Science 2024-06-17 Lital Binyamin , Yoad Tewel , Hilit Segev , Eran Hirsch , Royi Rassin , Gal Chechik

Next-generation sequencing technologies generate millions of short sequence reads, which are usually aligned to a reference genome. In many applications, the key information required for downstream analysis is the number of reads mapping to…

Genomics · Quantitative Biology 2016-07-26 Yang Liao , Gordon K Smyth , Wei Shi

Gene-gene interactions play a crucial role in the manifestation of complex human diseases. Uncovering significant gene-gene interactions is a challenging task. Here, we present an innovative approach utilizing data-driven computational…

Artificial Intelligence · Computer Science 2024-10-22 Yifan Wu , Yuntao Yang , Zirui Liu , Zhao Li , Khushbu Pahwa , Rongbin Li , Wenjin Zheng , Xia Hu , Zhaozhuo Xu

Flow-based Transformer models have achieved state-of-the-art image generation performance, but often suffer from high inference latency and computational cost due to their large parameter sizes. To improve inference efficiency without…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Yuhang Ma , Bo Cheng , Shanyuan Liu , Hongyi Zhou , Liebucha Wu , Dawei Leng , Yuhui Yin

Deciphering complex gene-gene interactions remains challenging in transcriptomics as traditional methods often miss higher-order and nonlinear dependencies. This study introduces a quantum-inspired framework leveraging tensor networks (TNs)…

Molecular Networks · Quantitative Biology 2025-09-09 Olatz Sanz Larrarte , Borja Aizpurua , Reza Dastbasteh , Ruben M. Otxoa , Josu Etxezarreta Martinez

Counting the number of answers to conjunctive queries is a fundamental problem in databases that, under standard assumptions, does not have an efficient solution. The issue is inherently #P-hard, extending even to classes of acyclic…

Databases · Computer Science 2024-09-12 Hubie Chen , Gianluigi Greco , Stefan Mengel , Francesco Scarcello

This paper develops a Bayesian graphical model for fusing disparate types of count data. The motivating application is the study of bacterial communities from diverse high dimensional features, in this case transcripts, collected from…

Text-to-image diffusion models generate realistic and coherent images but often fail to follow numerical instructions in text, revealing a gap between language and visual representation. Interestingly, we found that these models are not…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Hyemin Boo , Hyoryung Kim , Myungjin Lee , Seunghyeon Lee , Jiyoung Lee , Jang-Hwan Choi , Hyunsoo Cho