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Building and deploying machine learning solutions in healthcare remains expensive and labor-intensive due to fragmented preprocessing workflows, model compatibility issues, and stringent data privacy constraints. In this work, we introduce…

Artificial Intelligence · Computer Science 2025-07-25 Soorya Ram Shimgekar , Shayan Vassef , Abhay Goyal , Navin Kumar , Koustuv Saha

The integration of AI-assisted biomedical image analysis into clinical practice demands AI-generated findings that are not only accurate but also interpretable to clinicians. However, existing biomedical AI models generally lack the ability…

The wide-spread adoption of representation learning technologies in clinical decision making strongly emphasizes the need for characterizing model reliability and enabling rigorous introspection of model behavior. While the former need is…

Machine Learning · Computer Science 2020-05-01 Jayaraman J. Thiagarajan , Prasanna Sattigeri , Deepta Rajan , Bindya Venkatesh

Predictive artificial intelligence (AI) offers an opportunity to improve clinical practice and patient outcomes, but risks perpetuating biases if fairness is inadequately addressed. However, the definition of "fairness" remains unclear. We…

In healthcare there is a pursuit for employing interpretable algorithms to assist healthcare professionals in several decision scenarios. Following the Predictive, Descriptive and Relevant (PDR) framework, the definition of interpretable…

Despite the great promise that machine learning has offered in many fields of medicine, it has also raised concerns about potential biases and poor generalization across genders, age distributions, races and ethnicities, hospitals, and data…

Machine Learning · Computer Science 2023-02-01 Rongguang Wang , Pratik Chaudhari , Christos Davatzikos

The surge in developing deep learning models for diagnosing skin lesions through image analysis is notable, yet their clinical black faces challenges. Current dermatology AI models have limitations: limited number of possible diagnostic…

Computer Vision and Pattern Recognition · Computer Science 2023-11-03 Deval Mehta , Brigid Betz-Stablein , Toan D Nguyen , Yaniv Gal , Adrian Bowling , Martin Haskett , Maithili Sashindranath , Paul Bonnington , Victoria Mar , H Peter Soyer , Zongyuan Ge

Large AI models, or foundation models, are models recently emerging with massive scales both parameter-wise and data-wise, the magnitudes of which can reach beyond billions. Once pretrained, large AI models demonstrate impressive…

Artificial Intelligence · Computer Science 2023-09-26 Jianing Qiu , Lin Li , Jiankai Sun , Jiachuan Peng , Peilun Shi , Ruiyang Zhang , Yinzhao Dong , Kyle Lam , Frank P. -W. Lo , Bo Xiao , Wu Yuan , Ningli Wang , Dong Xu , Benny Lo

Artificial Intelligence has emerged as a useful aid in numerous clinical applications for diagnosis and treatment decisions. Deep neural networks have shown same or better performance than clinicians in many tasks owing to the rapid…

Image and Video Processing · Electrical Eng. & Systems 2021-11-05 Zohaib Salahuddin , Henry C Woodruff , Avishek Chatterjee , Philippe Lambin

Diseases involve complex processes and modifications to the cellular machinery. The gene expression profile of the affected cells contains characteristic patterns linked to a disease. Hence, biological knowledge pertaining to a disease can…

Quantitative Methods · Quantitative Biology 2020-04-13 Thomas Gaudelet , Noel Malod-Dognin , Jon Sanchez-Valle , Vera Pancaldi , Alfonso Valencia , Natasa Przulj

Human-in-the-loop validation is essential in safety-critical clinical AI, yet the transition between initial model inference and expert correction is rarely analyzed as a structured signal. We introduce a diagnostic alignment framework in…

Artificial Intelligence · Computer Science 2026-02-27 Dimitrios P. Panagoulias , Evangelia-Aikaterini Tsichrintzi , Georgios Savvidis , Evridiki Tsoureli-Nikita

This paper examines what it means for a medical AI system to be right by grounding the question in a specific clinical context: the automatic classification of plasma cells in digitized bone marrow smears for the diagnosis of multiple…

Computer Vision and Pattern Recognition · Computer Science 2026-05-13 Antony Gitau

We present Doctorina MedBench, a comprehensive evaluation framework for agent-based medical AI based on the simulation of realistic physician-patient interactions. Unlike traditional medical benchmarks that rely on solving standardized test…

Computation and Language · Computer Science 2026-03-30 Anna Kozlova , Stanislau Salavei , Pavel Satalkin , Hanna Plotnitskaya , Sergey Parfenyuk

A myriad of measures to illustrate performance of predictive artificial intelligence (AI) models have been proposed in the literature. Selecting appropriate performance measures is essential for predictive AI models that are developed to be…

Medical artificial intelligence (AI) systems frequently lack systematic domain expertise integration, potentially compromising diagnostic reliability. This study presents an ontology-based framework for bone disease diagnosis, developed in…

Artificial Intelligence · Computer Science 2025-06-06 Loan Dao , Ngoc Quoc Ly

Deep Learning based models are currently dominating most state-of-the-art solutions for disease prediction. Existing works employ RNNs along with multiple levels of attention mechanisms to provide interpretability. These deep learning…

Machine Learning · Statistics 2022-06-01 Subhadip Maji , Raghav Bali , Sree Harsha Ankem , Kishore V Ayyadevara

Engagement in Human-Machine Interaction is the process by which entities participating in the interaction establish, maintain, and end their perceived connection. It is essential to monitor the engagement state of patients in various…

Human-Computer Interaction · Computer Science 2023-03-03 Hanan Salam

Emerging AI regulations assign distinct obligations to different actors along the AI value chain (e.g., the EU AI Act distinguishes providers and deployers for both AI models and AI systems), yet the foundational terms "AI model" and "AI…

Computers and Society · Computer Science 2026-03-18 Yuanyuan Sun , Timothy Parker , Lara Gierschmann , Sana Shams , Teo Canmetin , Mathieu Duteil , Rokas Gipiškis , Ze Shen Chin

Machine Learning (ML) algorithms are vital for supporting clinical decision-making in biomedical informatics. However, their predictive performance can vary across demographic groups, often due to the underrepresentation of historically…

Machine Learning · Computer Science 2025-03-04 Ioannis Bilionis , Ricardo C. Berrios , Luis Fernandez-Luque , Carlos Castillo

Artificial intelligence (AI) is increasingly integrated into modern healthcare, offering powerful support for clinical decision-making. However, in real-world settings, AI systems may experience performance degradation over time, due to…

Artificial Intelligence · Computer Science 2026-02-05 Hao Guan , David Bates , Li Zhou