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Protein Language Models (PLMs), pre-trained on extensive evolutionary data from natural proteins, have emerged as indispensable tools for protein design. While powerful, PLMs often struggle to produce proteins with precisely specified…

Biomolecules · Quantitative Biology 2025-09-15 Long-Kai Huang , Rongyi Zhu , Bing He , Jianhua Yao

Computer-aided design (CAD) is a way to digitally create 2D drawings and 3D models of real-world products. Traditional CAD typically relies on hand-drawing by experts or modifications of existing library files, which doesn't allow for rapid…

Graphics · Computer Science 2025-05-14 Changqi He , Shuhan Zhang , Liguo Zhang , Jiajun Miao

We propose an end-to-end pipeline to robustly generate high-quality, high-order and coarse quadrilateral meshes on CAD models. This kind of mesh enables the use of high-order analysis techniques such as high-order finite element methods or…

Computational Engineering, Finance, and Science · Computer Science 2021-08-06 Mattéo Couplet , Maxence Reberol , Jean-François Remacle

Prompt-driven image analysis converts a single natural-language instruction into multiple steps: locate, segment, edit, and describe. We present a practical case study of a unified pipeline that combines open-vocabulary detection,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-11 Kaleem Ahmad

Despite recent progress, recovering parametric CAD construction sequences from geometric input, such as meshes or point clouds, is a key challenge for design and manufacturing, as existing CAD reconstruction and generation methods are…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Ghadi Nehme , Eamon Whalen , Faez Ahmed

Tool learning has emerged as a crucial capability for large language models (LLMs) to solve complex real-world tasks through interaction with external tools. Existing approaches face significant challenges, including reliance on…

Computation and Language · Computer Science 2025-06-02 Hanxing Ding , Shuchang Tao , Liang Pang , Zihao Wei , Jinyang Gao , Bolin Ding , Huawei Shen , Xueqi Cheng

Access to large amounts of diverse design solutions can support designers during the early stage of the design process. In this paper, we explore the efficacy of large language models (LLM) in producing diverse design solutions,…

Human-Computer Interaction · Computer Science 2024-05-07 Kevin Ma , Daniele Grandi , Christopher McComb , Kosa Goucher-Lambert

Goal-oriented de novo molecule design, namely generating molecules with specific property or substructure constraints, is a crucial yet challenging task in drug discovery. Existing methods, such as Bayesian optimization and reinforcement…

Computational Engineering, Finance, and Science · Computer Science 2025-02-28 Chuanliu Fan , Ziqiang Cao , Zicheng Ma , Nan Yu , Yimin Peng , Jun Zhang , Yiqin Gao , Guohong Fu

Today, large language models have demonstrated their strengths in various tasks ranging from reasoning, code generation, and complex problem solving. However, this advancement comes with a high computational cost and memory requirements,…

Machine Learning · Computer Science 2026-03-26 Meriem Bouzouad , Yuan-Hao Chang , Jalil Boukhobza

Understanding human instructions to identify the target objects is vital for perception systems. In recent years, the advancements of Large Language Models (LLMs) have introduced new possibilities for image segmentation. In this work, we…

Computer Vision and Pattern Recognition · Computer Science 2024-04-16 Junchi Wang , Lei Ke

Prototyping complex computer-aided design (CAD) models in modern softwares can be very time-consuming. This is due to the lack of intelligent systems that can quickly generate simpler intermediate parts. We propose Text2CAD, the first AI…

Computer Vision and Pattern Recognition · Computer Science 2024-09-26 Mohammad Sadil Khan , Sankalp Sinha , Talha Uddin Sheikh , Didier Stricker , Sk Aziz Ali , Muhammad Zeshan Afzal

In software engineering processes, systems are first specified using a modeling language such as UML. These initial designs are often collaboratively created, many times in meetings where different domain experts use whiteboards, paper or…

Software Engineering · Computer Science 2024-12-10 Aaron Conrardy , Jordi Cabot

Instruction tuning has emerged as the key in aligning large language models (LLMs) with specific task instructions, thereby mitigating the discrepancy between the next-token prediction objective and users' actual goals. To reduce the labor…

Computation and Language · Computer Science 2024-04-10 Zifeng Wang , Chun-Liang Li , Vincent Perot , Long T. Le , Jin Miao , Zizhao Zhang , Chen-Yu Lee , Tomas Pfister

Computer-aided design (CAD) is the most widely used modeling approach for technical design. The typical starting point in these designs is 2D sketches which can later be extruded and combined to obtain complex three-dimensional assemblies.…

Machine Learning · Computer Science 2021-06-08 Wamiq Reyaz Para , Shariq Farooq Bhat , Paul Guerrero , Tom Kelly , Niloy Mitra , Leonidas Guibas , Peter Wonka

Recently, large language models (LLMs) have demonstrated impressive results but still suffer from hallucinations. Model editing has been proposed to correct factual inaccuracies in LLMs. A challenging case is sequential model editing (SME),…

Computation and Language · Computer Science 2025-06-24 Taolin Zhang , Haidong Kang , Dongyang Li , Qizhou Chen , Chengyu Wang Xiaofeng He , Richang Hong

Consistency is a fundamental dimension of trustworthiness in Large Language Models (LLMs). For humans to be able to trust LLM-based applications, their outputs should be consistent when prompted with inputs that carry the same meaning or…

Computation and Language · Computer Science 2025-02-25 Harsh Raj , Vipul Gupta , Domenic Rosati , Subhabrata Majumdar

Code generation refers to automatically producing executable programs from user requirements. Recently, researchers have explored approaches to enhance the correctness of generated code with advanced large language models. Although…

Software Engineering · Computer Science 2026-04-20 Jia Li , Ruiqi Bai , Yangkang Luo , Yiran Zhang , Wentao Yang , Zeyu Sun , Tiankuo Zhao , Dongming Jin , Lei Li , Zhi Jin

Parametric Computer-aided design (CAD) enables the creation of reusable models by integrating variables into geometric properties, facilitating customization without a complete redesign. However, creating parametric designs in…

Human-Computer Interaction · Computer Science 2024-08-06 J. Felipe Gonzalez , Thomas Pietrzak , Audrey Girouard , Géry Casiez

Interleaved image-text generation has emerged as a crucial multimodal task, aiming at creating sequences of interleaved visual and textual content given a query. Despite notable advancements in recent multimodal large language models…

Computer Vision and Pattern Recognition · Computer Science 2025-04-03 Wei Chen , Lin Li , Yongqi Yang , Bin Wen , Fan Yang , Tingting Gao , Yu Wu , Long Chen

Computer Aided Design (CAD), especially the feature-based parametric CAD, plays an important role in modern industry and society. However, the reconstruction of featured CAD model is more challenging than the reconstruction of other CAD…

Computer Vision and Pattern Recognition · Computer Science 2023-10-05 Zhihao Zong , Fazhi He , Rubin Fan , Yuxin Liu