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Retrieval-augmented generation (RAG) has emerged as a promising approach to enhance the performance of large language models (LLMs) in knowledge-intensive tasks such as those from medical domain. However, the sensitive nature of the medical…

Computation and Language · Computer Science 2024-11-15 Nghia Trung Ngo , Chien Van Nguyen , Franck Dernoncourt , Thien Huu Nguyen

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented…

While Retrieval-Augmented Generation (RAG) has been swiftly adopted in scientific and clinical QA systems, a comprehensive evaluation benchmark in the medical domain is lacking. To address this gap, we introduce the Medical…

Computation and Language · Computer Science 2026-02-12 Liz Li , Wei Zhu

The rapid growth of medical knowledge and increasing complexity of clinical practice pose challenges. In this context, large language models (LLMs) have demonstrated value; however, inherent limitations remain. Retrieval-augmented…

Retriever-augmented generation (RAG) has become a widely adopted approach for enhancing the factual accuracy of large language models (LLMs). While current benchmarks evaluate the performance of RAG methods from various perspectives, they…

Information Retrieval · Computer Science 2025-04-08 Kepu Zhang , Zhongxiang Sun , Weijie Yu , Xiaoxue Zang , Kai Zheng , Yang Song , Han Li , Jun Xu

Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

Other Quantitative Biology · Quantitative Biology 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro

Retrieval-Augmented Generation (RAG) is an effective approach to enhance the factual accuracy of large language models (LLMs) by retrieving information from external databases, which are typically composed of diverse sources, to supplement…

Machine Learning · Computer Science 2025-10-15 Jeongyeon Hwang , Junyoung Park , Hyejin Park , Dongwoo Kim , Sangdon Park , Jungseul Ok

Despite Retrieval-Augmented Generation (RAG) showing promising capability in leveraging external knowledge, a comprehensive evaluation of RAG systems is still challenging due to the modular nature of RAG, evaluation of long-form responses…

Large language models (LLM) hold significant potential for applications in biomedicine, but they struggle with hallucinations and outdated knowledge. While retrieval-augmented generation (RAG) is generally employed to address these issues,…

Computation and Language · Computer Science 2025-09-23 Jiwoong Sohn , Yein Park , Chanwoong Yoon , Sihyeon Park , Hyeon Hwang , Mujeen Sung , Hyunjae Kim , Jaewoo Kang

Large language models (LLMs) have demonstrated strong capabilities in medical question answering; however, purely parametric models often suffer from knowledge gaps and limited factual grounding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2026-04-09 Nusrat Sultana , Abdullah Muhammad Moosa , Kazi Afzalur Rahman , Sajal Chandra Banik

Retrieval Augmented Generation (RAG) complements the knowledge of Large Language Models (LLMs) by leveraging external information to enhance response accuracy for queries. This approach is widely applied in several fields by taking its…

Retrieval-augmented generation (RAG) is a prevalent approach for building LLM-based question-answering systems that can take advantage of external knowledge databases. Due to the complexity of real-world RAG systems, there are many…

Computation and Language · Computer Science 2026-01-16 Kin Kwan Leung , Mouloud Belbahri , Yi Sui , Alex Labach , Xueying Zhang , Stephen Anthony Rose , Jesse C. Cresswell

Medical question-answering (QA) systems can benefit from advances in large language models (LLMs), but directly applying LLMs to the clinical domain poses challenges such as maintaining factual accuracy and avoiding hallucinations. In this…

Computation and Language · Computer Science 2025-12-08 Tasnimul Hassan , Md Faisal Karim , Haziq Jeelani , Elham Behnam , Robert Green , Fayeq Jeelani Syed

Retrieval-Augmented Generation (RAG) has emerged as a critical technique for enhancing large language model (LLM) capabilities. However, practitioners face significant challenges when making RAG deployment decisions. While existing research…

Software Engineering · Computer Science 2025-07-22 Shengming Zhao , Yuchen Shao , Yuheng Huang , Jiayang Song , Zhijie Wang , Chengcheng Wan , Lei Ma

Proprietary corporate documents contain rich domain-specific knowledge, but their overwhelming volume and disorganized structure make it difficult even for employees to access the right information when needed. For example, in the…

Artificial Intelligence · Computer Science 2025-08-28 Nayoung Choi , Grace Byun , Andrew Chung , Ellie S. Paek , Shinsun Lee , Jinho D. Choi

Advancements in model algorithms, the growth of foundational models, and access to high-quality datasets have propelled the evolution of Artificial Intelligence Generated Content (AIGC). Despite its notable successes, AIGC still faces…

Computer Vision and Pattern Recognition · Computer Science 2024-06-24 Penghao Zhao , Hailin Zhang , Qinhan Yu , Zhengren Wang , Yunteng Geng , Fangcheng Fu , Ling Yang , Wentao Zhang , Jie Jiang , Bin Cui

Medical question answering (QA) requires extensive access to domain-specific knowledge. A promising direction is to enhance large language models (LLMs) with external knowledge retrieved from medical corpora or parametric knowledge stored…

Computation and Language · Computer Science 2025-10-22 Lei Li , Xiao Zhou , Yingying Zhang , Xian Wu

Biomedical question-answering (QA) systems require effective retrieval and generation components to ensure accuracy, efficiency, and scalability. This study systematically examines a Retrieval-Augmented Generation (RAG) system for…

Information Retrieval · Computer Science 2026-01-14 Linus Stuhlmann , Michael Alexander Saxer , Jonathan Fürst

The recent emergence of Medical Large Vision Language Models (Med-LVLMs) has enhanced medical diagnosis. However, current Med-LVLMs frequently encounter factual issues, often generating responses that do not align with established medical…

Machine Learning · Computer Science 2024-10-18 Peng Xia , Kangyu Zhu , Haoran Li , Hongtu Zhu , Yun Li , Gang Li , Linjun Zhang , Huaxiu Yao

Deploying Large Language Models (LLMs) for healthcare question answering requires robust methods to ensure accuracy and reliability. This work introduces Query-Based Retrieval Augmented Generation (QB-RAG), a framework for enhancing…

Machine Learning · Computer Science 2025-07-31 Eric Yang , Jonathan Amar , Jong Ha Lee , Bhawesh Kumar , Yugang Jia
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