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Target Safety Assessment (TSA) requires systematic integration of heterogeneous evidence, including genetic, transcriptomic, target homology, pharmacological, and clinical data, to evaluate potential safety liabilities of therapeutic…

Computation and Language · Computer Science 2026-05-11 Xiaochen Zheng , Zhiwen Jiang , Melanie Guerard , Klas Hatje , Tatyana Doktorova

Agentic reinforcement learning has advanced large language models (LLMs) to reason through long chain-of-thought trajectories while interleaving external tool use. Existing approaches assume a fixed inventory of tools, limiting LLM agents'…

Computation and Language · Computer Science 2025-12-16 Jiaru Zou , Ling Yang , Yunzhe Qi , Sirui Chen , Mengting Ai , Ke Shen , Jingrui He , Mengdi Wang

We study how to allocate a fixed supervised fine-tuning budget when three objectives must be balanced at once: multi-turn safety alignment, low over-refusal on benign boundary queries, and instruction following under verifiable constraints.…

Cryptography and Security · Computer Science 2026-03-20 Yipu Dou , Wang Yang

Information Retrieval is shifting from passive document ranking toward autonomous agentic workflows that operate in multi-step Reason-Act-Observe loops. In such long-horizon trajectories, minor early errors can cascade, leading to…

Artificial Intelligence · Computer Science 2026-04-14 Anushree Sinha , Srivaths Ranganathan , Debanshu Das , Abhishek Dharmaratnakar

Extracting actionable insights from complex value stream map simulations can be challenging, time-consuming, and error-prone. Recent advances in large language models offer new avenues to support users with this task. While existing…

Computation and Language · Computer Science 2026-04-15 Micha Selak , Dirk Krechel , Adrian Ulges , Sven Spieckermann , Niklas Stoehr , Andreas Loehr

Modern Artificial Intelligence (AI) increasingly relies on multi-agent architectures that blend visual and language understanding. Yet, a pressing challenge remains: How can we trust these agents especially in zero-shot settings with no…

Artificial Intelligence · Computer Science 2025-09-23 Konstantinos I. Roumeliotis , Ranjan Sapkota , Manoj Karkee , Nikolaos D. Tselikas

This paper proposes the Cooperative Soft Actor Critic (CSAC) method of enabling consecutive reinforcement learning agents to cooperatively solve a long time horizon multi-stage task. This method is achieved by modifying the policy of each…

Machine Learning · Computer Science 2020-07-02 Jordan Erskine , Chris Lehnert

Performing simple household tasks based on language directives is very natural to humans, yet it remains an open challenge for AI agents. The 'interactive instruction following' task attempts to make progress towards building agents that…

Artificial Intelligence · Computer Science 2021-09-03 Kunal Pratap Singh , Suvaansh Bhambri , Byeonghwi Kim , Roozbeh Mottaghi , Jonghyun Choi

Web agents based on large language models have demonstrated promising capability in automating web tasks. However, current web agents struggle to reason out sensible actions due to the limitations of predicting environment changes, and…

Artificial Intelligence · Computer Science 2026-02-18 Zhouzhou Shen , Xueyu Hu , Xiyun Li , Tianqing Fang , Juncheng Li , Shengyu Zhang

With the wide application of multimodal foundation models in intelligent agent systems, scenarios such as mobile device control, intelligent assistant interaction, and multimodal task execution are gradually relying on such large…

Artificial Intelligence · Computer Science 2025-07-02 Siyuan Liang , Tianmeng Fang , Zhe Liu , Aishan Liu , Yan Xiao , Jinyuan He , Ee-Chien Chang , Xiaochun Cao

Agentic AIs $-$ AIs that are capable and permitted to undertake complex actions with little supervision $-$ mark a new frontier in AI capabilities and raise new questions about how to safely create and align such systems with users,…

Computers and Society · Computer Science 2024-10-04 Hayley Clatterbuck , Clinton Castro , Arvo Muñoz Morán

Multi-agent systems (MAS) have recently emerged as promising socio-collaborative companions for emotional and cognitive support. However, these systems frequently suffer from persona collapse--where agents revert to generic, homogenized…

Computation and Language · Computer Science 2026-01-21 Yiyang Wang , Yiqiao Jin , Alex Cabral , Josiah Hester

Autonomous multi-agent systems (MAS) are useful for automating complex tasks but raise trust concerns due to risks such as miscoordination or goal misalignment. Explainability is vital for users' trust calibration, but explainable MAS face…

Artificial Intelligence · Computer Science 2025-10-30 Bálint Gyevnár , Christopher G. Lucas , Stefano V. Albrecht , Shay B. Cohen

Safe and explainable motion planning remains a central challenge in autonomous driving. While rule-based planners offer predictable and explainable behavior, they often fail to grasp the complexity and uncertainty of real-world traffic.…

Outcome-driven reinforcement learning has advanced reasoning in large language models (LLMs), but prevailing tool-augmented approaches train a single, monolithic policy that interleaves thoughts and tool calls under full context; this…

Artificial Intelligence · Computer Science 2025-10-08 Zhuofeng Li , Haoxiang Zhang , Seungju Han , Sheng Liu , Jianwen Xie , Yu Zhang , Yejin Choi , James Zou , Pan Lu

Large language model (LLM) agents increasingly rely on external tools (file operations, API calls, database transactions) to autonomously complete complex multi-step tasks. Practitioners deploy defense-trained models to protect against…

Cryptography and Security · Computer Science 2026-03-23 Shawn Li , Yue Zhao

Large language models increasingly operate as autonomous agents that select and invoke tools from large registries. We identify a critical gap: when unauthorized tools are visible in an agent's context, models select them in adversarial…

Cryptography and Security · Computer Science 2026-05-19 Rohith Uppala

Open agentic systems combine LLM-based planning with external capabilities, persistent memory, and privileged execution. They are used in coding assistants, browser copilots, and enterprise automation. OpenClaw is a visible instance of this…

Cryptography and Security · Computer Science 2026-03-30 Shiping Chen , Qin Wang , Guangsheng Yu , Xu Wang , Liming Zhu

Agentic AI will be an essential enabling technology for designing future mobile communication systems, which could provide flexible and customized services, automate complex network operations, and drive autonomous decision-making across…

Networking and Internet Architecture · Computer Science 2026-05-05 Purna Sai Garigipati , Onur Ayan , Kishor Chandra Joshi , Xueli An

Metasurface inverse design has become central to realizing complex optical functionality, yet translating target responses into executable, solver-compatible workflows still demands specialized expertise in computational electromagnetics…

Artificial Intelligence · Computer Science 2026-04-03 Yi Huang , Bowen Zheng , Yunxi Dong , Hong Tang , Huan Zhao , S. M. Rakibul Hasan Shawon , Hualiang Zhang