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AI-assisted molecular property prediction has become a promising technique in early-stage drug discovery and materials design in recent years. However, due to high-cost and complex wet-lab experiments, real-world molecules usually…

Computational Engineering, Finance, and Science · Computer Science 2025-10-13 Zeyu Wang , Tianyi Jiang , Huanchang Ma , Yao Lu , Xiaoze Bao , Shanqing Yu , Qi Xuan , Shirui Pan , Xin Zheng

Machine learning is widely applied in modern society, but has yet to capitalise on the unique benefits offered by quantum resources. Boson sampling -- a quantum-interference based sampling protocol -- is a resource that is classically hard…

Deep learning is an important method for molecular design and exhibits considerable ability to predict molecular properties, including physicochemical, bioactive, and ADME/T (absorption, distribution, metabolism, excretion, and toxicity)…

Molecular Networks · Quantitative Biology 2022-05-10 Hanxuan Cai , Huimin Zhang , Duancheng Zhao , Jingxing Wu , Ling Wang

We present a machine-learning method for predicting sharp transitions in a Hamiltonian phase diagram by extrapolating the properties of quantum systems. The method is based on Gaussian Process regression with a combination of kernels chosen…

Other Condensed Matter · Physics 2019-04-26 Rodrigo A. Vargas-Hernández , John Sous , Mona Berciu , Roman V. Krems

Rapid, non-destructive characterization of molecular level chemistry for organic matter (OM) is experimentally challenging. Raman spectroscopy is one of the most widely used techniques for non-destructive chemical characterization, although…

Materials Science · Physics 2016-02-08 Yun Liu , Nicola Ferralis , L. Taras Bryndzia , Jeffrey C. Grossman

Quantum mechanics features a variety of distinct properties such as coherence and entanglement, which could be explored to showcase potential advantages over classical counterparts in information processing. In general, legitimate quantum…

Quantum Physics · Physics 2023-08-17 Fuchuan Wei , Zhenhuan Liu , Guoding Liu , Zizhao Han , Xiongfeng Ma , Dong-Ling Deng , Zhengwei Liu

We consider the prediction of the Hamiltonian matrix, which finds use in quantum chemistry and condensed matter physics. Efficiency and equivariance are two important, but conflicting factors. In this work, we propose a SE(3)-equivariant…

Machine Learning · Computer Science 2023-11-09 Haiyang Yu , Zhao Xu , Xiaofeng Qian , Xiaoning Qian , Shuiwang Ji

The accurate treatment of electron correlation in extended molecular systems remains computationally challenging using classical electronic structure methods. Hybrid quantum-classical algorithms offer a potential route to overcome these…

Topological materials exhibit unique electronic structures that underpin both fundamental quantum phenomena and next-generation technologies, yet their discovery remains constrained by the high computational cost of first-principles…

Materials Science · Physics 2025-12-16 Xinyu Xu , Rajibul Islam , Ghulam Hussain , Yangming Huang , Xiaoguang Li , Pavlo O. Dral , Arif Ullah , Ming Yang

The interpretation of experiments on reactive semiconductor surfaces requires statistically significant sampling of molecular dynamics, but conventional ab initio methods are limited due to prohibitive computational costs. Machine-learning…

Materials Science · Physics 2025-09-19 Hendrik Weiske , Rhyan Barrett , Ralf Tonner-Zech , Patrick Melix , Julia Westermayr

Efficient sampling from ensembles of Hamiltonian cycles is critical for predicting the thermodynamic properties of compact polymers, with applications including modeling protein and RNA folding and designing soft materials. Although…

Quantum Physics · Physics 2026-03-16 Davide Rattacaso , Daniel Jaschke , Antonio Trovato , Ilaria Siloi , Simone Montangero

Semiconductor crosshatch patterns in thin film heterostructures form as a result of strain relaxation processes and dislocation pile-ups during growth of lattice mismatched materials. Due to their connection with the internal misfit…

In order to utilize identification to the best extent, we need robust and fast algorithms and systems to process the data. Having palmprint as a reliable and unique characteristic of every person, we extract and use its features based on…

Computer Vision and Pattern Recognition · Computer Science 2015-02-13 Shervin Minaee , AmirAli Abdolrashidi

One of the key challenges in quantum machine learning is finding relevant machine learning tasks with a provable quantum advantage. A natural candidate for this is learning unknown Hamiltonian dynamics. Here, we tackle the supervised…

Quantum Physics · Physics 2025-06-23 Alice Barthe , Mahtab Yaghubi Rad , Michele Grossi , Vedran Dunjko

High-throughput approximations of quantum mechanics calculations and combinatorial experiments have been traditionally used to reduce the search space of possible molecules, drugs and materials. However, the interplay of structural and…

Quantum Physics · Physics 2019-10-29 Alain Tchagang , Julio Valdés

Quantum simulation provides a powerful route for exploring many-body phenomena beyond the capabilities of classical computation. Existing approaches typically proceed in the forward direction: a model Hamiltonian is specified, implemented…

Quantum mechanics based ab-initio molecular dynamics (MD) simulation schemes offer an accurate and direct means to monitor the time-evolution of materials. Nevertheless, the expensive and repetitive energy and force computations required in…

Materials Science · Physics 2014-10-14 Venkatesh Botu , Rampi Ramprasad

Predicting bioactivity and physical properties of molecules is a longstanding challenge in drug design. Most approaches use molecular descriptors based on a 2D representation of molecules as a graph of atoms and bonds, abstracting away the…

Quantitative Methods · Quantitative Biology 2020-10-27 William McCorkindale , Carl Poelking , Alpha A. Lee

Atomic properties such as partial charges or multipoles encode chemically meaningful information that can inform downstream molecular property prediction, but their evaluation as machine learning targets has been complicated by the absence…

Eficient, physically-inspired descriptors of the structure and composition of molecules and materials play a key role in the application of machine-learning techniques to atomistic simulations. The proliferation of approaches, as well as…

Computational Physics · Physics 2020-12-11 Alexander Goscinski , Guillaume Fraux , Giulio Imbalzano , Michele Ceriotti
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