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Accurate ADMET (an abbreviation for "absorption, distribution, metabolism, excretion, and toxicity") predictions can efficiently screen out undesirable drug candidates in the early stage of drug discovery. In recent years, multiple…

Biomolecules · Quantitative Biology 2022-05-25 Shanzhuo Zhang , Zhiyuan Yan , Yueyang Huang , Lihang Liu , Donglong He , Wei Wang , Xiaomin Fang , Xiaonan Zhang , Fan Wang , Hua Wu , Haifeng Wang

Machine-learning of atomic-scale properties amounts to extracting correlations between structure, composition and the quantity that one wants to predict. Representing the input structure in a way that best reflects such correlations makes…

Chemical Physics · Physics 2021-02-02 Michael J. Willatt , Félix Musil , Michele Ceriotti

Efficiently characterising quantum systems, verifying operations of quantum devices and validating underpinning physical models, are central challenges for the development of quantum technologies and for our continued understanding of…

Extracting the Hamiltonian parameters of nanoscale quantum magnets from experimental measurements is a significant challenge in quantum matter. Here we establish a machine learning strategy to extract the parameters of a spin Hamiltonian…

Mesoscale and Nanoscale Physics · Physics 2025-09-11 Rouven Koch , Robert Drost , Peter Liljeroth , Jose L. Lado

The required precision to perform quantum simulations beyond the capabilities of classical computers imposes major experimental and theoretical challenges. The key to solving these issues are precise means of characterizing analog quantum…

Quantum Physics · Physics 2024-11-11 Dominik Hangleiter , Ingo Roth , Jonas Fuksa , Jens Eisert , Pedram Roushan

We demonstrate the application of a quantum feature extraction method to enhance multi-class image classification for space applications. By harnessing the dynamics of many-body spin Hamiltonians, the method generates expressive quantum…

Machine learning (ML) has been playing important roles in drug discovery in the past years by providing (pre-)screening tools for prioritising chemical compounds to pass through wet lab experiments. One of the main ML tasks in drug…

Biomolecules · Quantitative Biology 2025-02-25 Alex G. C. de Sá , David B. Ascher

Structural fingerprints and pharmacophore modeling are methodologies that have been used for at least two decades in various fields of cheminformatics: from similarity searching to machine learning (ML). Advances in silico techniques…

Quantitative Methods · Quantitative Biology 2023-11-01 Dawid Warszycki , Łukasz Struski , Marek Śmieja , Rafał Kafel , Rafał Kurczab

Hamiltonian parameter estimation is crucial in condensed matter physics, but time and cost consuming in terms of resources used. With advances in observation techniques, high-resolution images with more detailed information are obtained,…

Disordered Systems and Neural Networks · Physics 2019-11-15 Dingchen Wang , Songrui Wei , Anran Yuan , Fanghua Tian , Kaiyan Cao , Qizhong Zhao , Dezhen Xue , Sen Yang

In the computational prediction of chemical compound properties, molecular descriptors and fingerprints encoded to low dimensional vectors are used. The selection of proper molecular descriptors and fingerprints is both important and…

Machine Learning · Computer Science 2020-10-23 Sangrak Lim , Yong Oh Lee

Purpose: We propose a general framework for quantifying predictive uncertainties of dose-related quantities and leveraging this information in a dose mimicking problem in the context of automated radiation therapy treatment planning.…

Medical Physics · Physics 2021-09-08 Tianfang Zhang , Rasmus Bokrantz , Jimmy Olsson

We propose a novel decentralized feature extraction approach in federated learning to address privacy-preservation issues for speech recognition. It is built upon a quantum convolutional neural network (QCNN) composed of a quantum circuit…

A central challenge in analog quantum simulation is to characterize desirable physical properties of quantum states produced in experiments. However, in conventional approaches, the extraction of arbitrary information requires performing…

Quantum Physics · Physics 2023-04-04 Minh C. Tran , Daniel K. Mark , Wen Wei Ho , Soonwon Choi

The answers to many unsolved problems lie in the intractable chemical space of molecules and materials. Machine learning techniques are rapidly growing in popularity as a way to compress and explore chemical space efficiently. One of the…

Chemical Physics · Physics 2020-01-06 John E. Herr , Kevin Koh , Kun Yao , John Parkhill

Quantum process characterization is a fundamental task in quantum information processing, yet conventional methods, such as quantum process tomography, require prohibitive resources and lack scalability. Here, we introduce an efficient…

Quantum Physics · Physics 2025-04-11 Yusen Wu , Yukun Zhang , Chuan Wang , Xiao Yuan

The absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties are important in drug discovery as they define efficacy and safety. In this work, we applied an ensemble of features, including fingerprints and…

Biomolecules · Quantitative Biology 2022-09-20 Hao Tian , Rajas Ketkar , Peng Tao

The prediction of absorption, distribution, metabolism, excretion, and toxicity (ADMET) of small molecules from their molecular structure is a central problem in medicinal chemistry with great practical importance in drug discovery.…

The quantum Hamiltonian is a fundamental property that governs a molecule's electronic structure and behavior, and its calculation and prediction are paramount in computational chemistry and materials science. Accurate prediction is highly…

Computational Engineering, Finance, and Science · Computer Science 2026-01-23 Zhenzhong Wang , Yongjie Hou , Chenggong Huang , Yuxuan Du , Dacheng Tao , Min Jiang

We introduce HAML (Hamiltonian Adaptation via Meta-Learning), a framework for fast online adaptation of effective Hamiltonian models of superconducting quantum processors. HAML proceeds in two phases. A supervised training phase uses an…

Quantum Physics · Physics 2026-04-29 Arielle Sanford , Andrew T. Kamen , Frederic T. Chong , Andy J. Goldschmidt

Determining the Hamiltonian of a quantum system is essential for understanding its dynamics and validating its behavior. Hamiltonian learning provides a data-driven approach to reconstruct the generator of the dynamics from measurements on…