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Large-scale neuroscience is generating rich datasets across animals, brain areas and behavioral contexts, yet our modeling efforts remains fragmented across isolated experiments. We argue that understanding behavior requires integrative…

Neuroimaging-driven prediction of brain age, defined as the predicted biological age of a subject using only brain imaging data, is an exciting avenue of research. In this work we seek to build models of brain age based on functional…

As deep learning systems are scaled up to many billions of parameters, relating their internal structure to external behaviors becomes very challenging. Although daunting, this problem is not new: Neuroscientists and cognitive scientists…

Network neuroscience is the emerging discipline concerned with investigating the complex patterns of interconnections found in neural systems, and to identify principles with which to understand them. Within this discipline, one…

Neurons and Cognition · Quantitative Biology 2017-08-29 Richard F. Betzel , Danielle S. Bassett

Degeneration and adaptation are two competing sides of the same coin called resilience in the progressive processes of brain aging or diseases. Degeneration accumulates during brain aging and other cerebral activities, causing structural…

Building machines that learn and think like humans is essential not only for cognitive science, but also for computational neuroscience, whose ultimate goal is to understand how cognition is implemented in biological brains. A new cognitive…

Artificial Intelligence · Computer Science 2017-11-15 Nikolaus Kriegeskorte , Robert M. Mok

Human aging is a process controlled by both genetics and environment. Many studies have been conducted to identify a subset of genes related to aging from the human genome. Biologists implicitly categorize age-related genes into genes that…

Genomics · Quantitative Biology 2023-11-17 Salman Mohamadi , Donald A. Adjeroh

Network neuroscience represents the brain as a collection of regions and inter-regional connections. Given its ability to formalize systems-level models, network neuroscience has generated unique explanations of neural function and…

Neurons and Cognition · Quantitative Biology 2019-11-13 Maxwell A. Bertolero , Danielle S. Bassett

This thesis is a compendium of research which brings together ideas from the fields of Complex Networks and Computational Neuroscience to address two questions regarding neural systems: 1) How the activity of neurons, via synaptic changes,…

Neurons and Cognition · Quantitative Biology 2013-02-19 Samuel Johnson

Network science has become an essential interdisciplinary tool for understanding complex biological systems. However, because these systems undergo continuous, often stimulus-driven changes in both structure and function, traditional static…

Molecular Networks · Quantitative Biology 2025-05-19 Abir Khazaal , Fatemeh Vafaee

This review highlights brain health as a dynamic process shaped by both genetic and environmental influences throughout development. Critical periods provide unique windows of heightened neural plasticity, during which genetic-environmental…

In recent years, neuroscience has made significant progress in building large-scale artificial neural network (ANN) models of brain activity and behavior. However, there is no consensus on the most efficient ways to collect data and design…

Computational modeling plays an increasingly important role in neuroscience, highlighting the philosophical question of how computational models explain. In the context of neural network models for neuroscience, concerns have been raised…

Neurons and Cognition · Quantitative Biology 2021-04-15 Rosa Cao , Daniel Yamins

This paper considers neural representation through the lens of active inference, a normative framework for understanding brain function. It delves into how living organisms employ generative models to minimize the discrepancy between…

Neurons and Cognition · Quantitative Biology 2023-10-24 Giovanni Pezzulo , Leo D'Amato , Francesco Mannella , Matteo Priorelli , Toon Van de Maele , Ivilin Peev Stoianov , Karl Friston

Recent studies have demonstrated that network approaches are highly appropriate tools to understand the extreme complexity of the aging process. The generality of the network concept helps to define and study the aging of technological,…

Molecular Networks · Quantitative Biology 2009-09-28 Gabor I. Simko , David Gyurko , Daniel V. Veres , Tibor Nanasi , Peter Csermely

Human decision-making underlies all economic behavior. For the past four decades, human decision-making under uncertainty has continued to be explained by theoretical models based on prospect theory, a framework that was awarded the Nobel…

Machine Learning · Computer Science 2019-06-21 David D. Bourgin , Joshua C. Peterson , Daniel Reichman , Thomas L. Griffiths , Stuart J. Russell

The response time of physical computational elements is finite, and neurons are no exception. In hierarchical models of cortical networks each layer thus introduces a response lag. This inherent property of physical dynamical systems…

Neurons and Cognition · Quantitative Biology 2021-10-28 Paul Haider , Benjamin Ellenberger , Laura Kriener , Jakob Jordan , Walter Senn , Mihai A. Petrovici

With recent and rapid advancements in artificial intelligence (AI), understanding the foundation of purposeful behaviour in autonomous agents is crucial for developing safe and efficient systems. While artificial neural networks have…

Artificial Intelligence · Computer Science 2025-08-12 Aswin Paul , Moein Khajehnejad , Forough Habibollahi , Brett J. Kagan , Adeel Razi

The network architecture of the human brain has become a feature of increasing interest to the neuroscientific community, largely because of its potential to illuminate human cognition, its variation over development and aging, and its…

Neurons and Cognition · Quantitative Biology 2016-11-07 Richard F. Betzel , Danielle S. Bassett

Neurotechnologies are transforming how we measure, interpret, and modulate brain-body interactions, integrating real-time sensing, computation, and stimulation to enable precise physiological control. They hold transformative potential…

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