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Humans and animals have the ability to continually acquire, fine-tune, and transfer knowledge and skills throughout their lifespan. This ability, referred to as lifelong learning, is mediated by a rich set of neurocognitive mechanisms that…

Machine Learning · Computer Science 2019-02-12 German I. Parisi , Ronald Kemker , Jose L. Part , Christopher Kanan , Stefan Wermter

In recent years, the field of neuroscience has gone through rapid experimental advances and a significant increase in the use of quantitative and computational methods. This growth has created a need for clearer analyses of the theory and…

Modern AI models, such as large language models, are usually trained once on a huge corpus of data, potentially fine-tuned for a specific task, and then deployed with fixed parameters. Their training is costly, slow, and gradual, requiring…

Artificial Intelligence · Computer Science 2025-07-04 Daniel Durstewitz , Bruno Averbeck , Georgia Koppe

Neuroscience is undergoing faster changes than ever before. Over 100 years our field qualitatively described and invasively manipulated single or few organisms to gain anatomical, physiological, and pharmacological insights. In the last 10…

Neurons and Cognition · Quantitative Biology 2016-08-12 Danilo Bzdok , B. T. Thomas Yeo

A complete understanding of the brain requires an integrated description of the numerous scales of neural organization. It means studying the interplay of genes, synapses, and even whole brain regions which ultimately leads to different…

Neurons and Cognition · Quantitative Biology 2022-08-09 Charley Presigny , Fabrizio De Vico Fallani

Neuroengineering is faced with unique challenges in repairing or replacing complex neural systems that are composed of many interacting parts. These interactions form intricate patterns over large spatiotemporal scales, and produce emergent…

Neurons and Cognition · Quantitative Biology 2016-12-26 Danielle S. Bassett , Ankit N. Khambhati , Scott T. Grafton

The deep neural nets of modern artificial intelligence (AI) have not achieved defining features of biological intelligence, including abstraction, causal learning, and energy-efficiency. While scaling to larger models has delivered…

Neurons and Cognition · Quantitative Biology 2021-05-24 Joseph D. Monaco , Kanaka Rajan , Grace M. Hwang

How can cognitive science build generalizable theories that span the full scope of natural situations and behaviors? We argue that progress in Artificial Intelligence (AI) offers timely opportunities for cognitive science to embrace…

Neurons and Cognition · Quantitative Biology 2026-05-25 Wilka Carvalho , Andrew Lampinen

Cognitive ageing seems to be a story of global degradation. As one ages there are a number of physical, chemical and biological changes that take place. Therefore it is logical to assume that the brain is no exception to this phenomenon.…

Adaptation and Self-Organizing Systems · Physics 2014-08-07 Sakyasingha Dasgupta

Many cognitive neuroscience studies use large feature sets to predict and interpret brain activity patterns. Feature sets take many forms, from human stimulus annotations to representations in deep neural networks. Of crucial importance in…

Neurons and Cognition · Quantitative Biology 2022-12-07 Anna A. Ivanova , Martin Schrimpf , Stefano Anzellotti , Noga Zaslavsky , Evelina Fedorenko , Leyla Isik

The differential diagnosis of neurodegenerative diseases, characterized by overlapping symptoms, may be challenging. Brain imaging coupled with artificial intelligence has been previously proposed for diagnostic support, but most of these…

Image and Video Processing · Electrical Eng. & Systems 2025-02-21 Pierrick Coupé , Boris Mansencal , José V. Manjón , Patrice Péran , Wassilios G. Meissner , Thomas Tourdias , Vincent Planche

The development of large-scale artificial intelligence (AI) models is influencing neuroscience research by enabling end-to-end learning from raw brain signals and neural data. In this paper, we review applications of large-scale AI models…

The gradual accumulation of damage and dysregulation during the aging of living organisms can be quantified. Even so, the aging process is complex and has multiple interacting physiological scales -- from the molecular to cellular to whole…

Quantitative Methods · Quantitative Biology 2021-05-06 Spencer Farrell , Garrett Stubbings , Kenneth Rockwood , Arnold Mitnitski , Andrew Rutenberg

We organized a workshop on the "Present and Future Frameworks of Theoretical Neuroscience", with the support of the National Science Foundation. The objective was to identify the challenges and strategies that this field will need to tackle…

Neurons and Cognition · Quantitative Biology 2020-04-06 Horacio G. Rotstein , Fidel Santamaria

Elucidating the language-brain relationship requires bridging the methodological gap between the abstract theoretical frameworks of linguistics and the empirical neural data of neuroscience. Serving as an interdisciplinary cornerstone,…

Neurons and Cognition · Quantitative Biology 2026-02-16 Fudong Zhang , Bo Chai , Yujie Wu , Wai Ting Siok , Nizhuan Wang

Neuroscience has long informed the development of artificial neural networks, but the success of modern architectures invites, in turn, the converse: can modern networks teach us lessons about brain function? Here, we examine the structure…

Neurons and Cognition · Quantitative Biology 2026-03-17 Peter Koenig , Mario Negrello

Current theories of decision making suggest that the neural circuits in mammalian brains (including humans) computationally combine representations of the past (memory), present (perception), and future (agentic goals) to take actions that…

Neuroscientists today can measure activity from more neurons than ever before, and are facing the challenge of connecting these brain-wide neural recordings to computation and behavior. Here, we first describe emerging tools and…

Neurons and Cognition · Quantitative Biology 2022-01-10 Anne E. Urai , Brent Doiron , Andrew M. Leifer , Anne K. Churchland

The ability to effectively control brain dynamics holds great promise for the enhancement of cognitive function in humans, and the betterment of their quality of life. Yet, successfully controlling dynamics in neural systems is challenging,…

Quantitative Methods · Quantitative Biology 2018-08-29 Evelyn Tang , Danielle S. Bassett

One of the defining features of living systems is their adaptability to changing environmental conditions. This requires organisms to extract temporal and spatial features of their environment, and use that information to compute the…

Neurons and Cognition · Quantitative Biology 2024-02-27 Maria Sol Vidal-Saez , Oscar Vilarroya , Jordi Garcia-Ojalvo