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We study a stochastic perishable inventory control problem with endogenous (decision-dependent) uncertainty in shelf-life of units. Our primary motivation is determining ordering policies for blood platelets. Determining optimal ordering…

Systems and Control · Electrical Eng. & Systems 2025-02-11 Hossein Abouee-Mehrizi , Mahdi Mirjalili , Vahid Sarhangian

Aging bridge networks require proactive, verifiable, and interpretable maintenance strategies, yet reinforcement learning (RL) policies trained solely on reward signals provide no formal safety guarantees and remain opaque to infrastructure…

Artificial Intelligence · Computer Science 2026-03-10 Dennis Gross

Efforts to reduce platelet wastage in hospital blood banks have focused on ordering policies, but the predominant practice of issuing the oldest unit first may not be optimal when some units are returned unused. We propose a novel, machine…

Machine Learning · Computer Science 2024-11-25 Joseph Farrington , Samah Alimam , Martin Utley , Kezhi Li , Wai Keong Wong

Safe and interpretable sequential decision-making is critical in healthcare, yet reinforcement learning (RL) policies for sepsis treatment optimization remain opaque and difficult to verify. Standard probabilistic model checkers operate on…

Artificial Intelligence · Computer Science 2026-02-17 Dennis Gross

We study inventory control policies for pharmaceutical supply chains, addressing challenges such as perishability, yield uncertainty, and non-stationary demand, combined with batching constraints, lead times, and lost sales. Collaborating…

Artificial Intelligence · Computer Science 2025-01-22 Francesco Stranieri , Chaaben Kouki , Willem van Jaarsveld , Fabio Stella

This paper introduces a novel reinforcement learning (RL) approach to scheduling mixed-criticality (MC) systems on processors with varying speeds. Building upon the foundation laid by [1], we extend their work to address the non-preemptive…

Machine Learning · Computer Science 2025-04-09 Muhammad El-Mahdy , Nourhan Sakr , Rodrigo Carrasco

Consumption Markov Decision Processes (CMDPs) are probabilistic decision-making models of resource-constrained systems. In a CMDP, the controller possesses a certain amount of a critical resource, such as electric power. Each action of the…

Formal Languages and Automata Theory · Computer Science 2020-05-18 František Blahoudek , Tomáš Brázdil , Petr Novotný , Melkior Ornik , Pranay Thangeda , Ufuk Topcu

This paper targets the efficient construction of a safety shield for decision making in scenarios that incorporate uncertainty. Markov decision processes (MDPs) are prominent models to capture such planning problems. Reinforcement learning…

Artificial Intelligence · Computer Science 2019-11-26 Nils Jansen , Bettina Könighofer , Sebastian Junges , Alexandru C. Serban , Roderick Bloem

Continuous Time Markov Chains (CTMC) have been used extensively to model reliability of storage systems. While the exponentially distributed sojourn time of Markov models is widely known to be unrealistic (and it is necessary to consider…

Performance · Computer Science 2015-03-30 Prasenjit Karmakar , K. Gopinath

As critically ill patients frequently develop anemia or coagulopathy, transfusion of blood products is a frequent intervention in the Intensive Care Units (ICU). However, inappropriate transfusion decisions made by physicians are often…

Machine Learning · Computer Science 2022-06-30 Yuqing Wang , Yun Zhao , Linda Petzold

This paper addresses the problem of learning control policies for mobile robots, modeled as unknown Markov Decision Processes (MDPs), that are tasked with temporal logic missions, such as sequencing, coverage, or surveillance. The MDP…

Robotics · Computer Science 2022-07-13 Yiannis Kantaros

Planning plays an important role in the broad class of decision theory. Planning has drawn much attention in recent work in the robotics and sequential decision making areas. Recently, Reinforcement Learning (RL), as an agent-environment…

Artificial Intelligence · Computer Science 2016-08-18 Kamyar Azizzadenesheli , Alessandro Lazaric , Animashree Anandkumar

Reinforcement Learning (RL) has emerged as an efficient method of choice for solving complex sequential decision making problems in automatic control, computer science, economics, and biology. In this paper we present a model-free RL…

Logic in Computer Science · Computer Science 2019-09-13 Mohammadhosein Hasanbeig , Yiannis Kantaros , Alessandro Abate , Daniel Kroening , George J. Pappas , Insup Lee

Scaling reinforcement learning (RL) has shown strong promise for enhancing the reasoning abilities of large language models (LLMs), particularly in tasks requiring long chain-of-thought generation. However, RL training efficiency is often…

Machine Learning · Computer Science 2026-03-25 Yiqi Zhang , Huiqiang Jiang , Xufang Luo , Zhihe Yang , Chengruidong Zhang , Yifei Shen , Dongsheng Li , Yuqing Yang , Lili Qiu , Yang You

This paper presents COOL-MC, a tool that integrates state-of-the-art reinforcement learning (RL) and model checking. Specifically, the tool builds upon the OpenAI gym and the probabilistic model checker Storm. COOL-MC provides the following…

Machine Learning · Computer Science 2022-09-16 Dennis Gross , Nils Jansen , Sebastian Junges , Guillermo A. Perez

Blood cultures are often over ordered without clear justification, straining healthcare resources and contributing to inappropriate antibiotic use pressures worsened by the global shortage. In study of 135483 emergency department (ED) blood…

We introduce a tool for rigorous and automated verification of large language model (LLM)- based policies in memoryless sequential decision-making tasks. Given a Markov decision process (MDP) representing the sequential decision-making…

Artificial Intelligence · Computer Science 2025-10-09 Dennis Gross , Helge Spieker , Arnaud Gotlieb

Repetitive laboratory testing unlikely to yield clinically useful information is a common practice that burdens patients and increases healthcare costs. Education and feedback interventions have limited success, while general test ordering…

Intraday surgical scheduling is a multi-objective decision problem under uncertainty-balancing elective throughput, urgent and emergency demand, delays, sequence-dependent setups, and overtime. We formulate the problem as a cooperative…

Machine Learning · Computer Science 2025-12-05 Kailiang Liu , Ying Chen , Ralf Borndörfer , Thorsten Koch

Blood transfusion is one of the most crucial and commonly administered therapeutics worldwide. The need for more accurate and efficient ways to manage blood demand and supply is an increasing concern. Building a technology-based, robust…

Applications · Statistics 2021-03-11 Na Li , Fei Chiang , Douglas G. Down , Nancy M. Heddle
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