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Accurate free-energy calculations are essential for predicting thermodynamic properties and phase stability, but existing methods are limited: phonon-based approaches neglect anharmonicity and liquids, while molecular dynamics (MD) is…

Materials Science · Physics 2025-11-19 Ekaterina Spirande , Timofei Miryashkin , Andrei Kolmakov , Alexander Shapeev

Direct simulation of biomolecular dynamics in thermal equilibrium is challenging due to the metastable nature of conformation dynamics and the computational cost of molecular dynamics. Biased or enhanced sampling methods may improve the…

Chemical Physics · Physics 2015-06-12 Benjamin Trendelkamp-Schroer , Frank Noe

Realistic simulations in engineering or in the materials sciences can consume enormous computing resources and thus require the use of massively parallel supercomputers. The probability of a failure increases both with the runtime and with…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-01-30 Nils Kohl , Johannes Hötzer , Florian Schornbaum , Martin Bauer , Christian Godenschwager , Harald Köstler , Britta Nestler , Ulrich Rüde

We report modifications of the ph-AFQMC algorithm that allow the use of large time steps and reliable time step extrapolation. Our modified algorithm eliminates size-consistency errors present in the standard algorithm when large time steps…

Chemical Physics · Physics 2024-03-06 Zoran Sukurma , Martin Schlipf , Moritz Humer , Amir Taheridehkordi , Georg Kresse

The development and implementation of increasingly accurate methods for electronic structure calculations mean that, for many atomistic simulation problems, treating light nuclei as classical particles is now one of the most serious…

Materials Science · Physics 2016-02-12 Venkat Kapil , Joost VandeVondele , Michele Ceriotti

Hamiltonian splitting methods are an established technique to derive stable and accurate integration schemes in molecular dynamics, in which additional accuracy can be gained using force gradients. For rigid bodies, a tradition exists in…

Statistical Mechanics · Physics 2008-04-10 Ramses van Zon , Igor P. Omelyan , Jeremy Schofield

Hypothesis A prototypical modelling approach is required for a full characterisation of the static and equilibrium dynamical properties of confined ionic liquids (ILs), in order to gain predictive power of properties that are difficult to…

We use molecular dynamics simulations to study the dynamics of an ensemble of interacting self-propelled semi-flexible polymers in contact with a thermal bath. Our intention is to model complex systems of biological interest. We find that…

Soft Condensed Matter · Physics 2011-05-06 Davide Loi , Stefano Mossa , Leticia F. Cugliandolo

We present a systematic framework for shortening and automating molecular dynamics equilibration through improved position initialization methods and uncertainty quantification analysis, using the Yukawa one-component plasma as an exemplar…

Computational Physics · Physics 2026-01-06 Luciano G. Silvestri , Zachary A. Johnson , Michael S. Murillo

Molecular dynamics simulations are carried out to investigate the diffusion behavior of penetrable-sphere model fluids characterized by a finite energy barrier $\epsilon$. The self-diffusion coefficient is evaluated from the time-dependent…

Soft Condensed Matter · Physics 2010-11-22 Soong-Hyuck Suh , Chun-Ho Kim , Soon-Chul Kim , Andrés Santos

A new upscaling procedure that provides 1D representations of 2D mixing-limited reactive transport systems is developed and applied. A key complication with upscaled models in this setting is that the procedure must differentiate between…

Fluid Dynamics · Physics 2022-10-05 Ricardo H. Deucher , Louis J. Durlofsky

Using very long molecular dynamics simulation runs, temperature protocols spanning up to five orders of magnitude in time-scales are performed to investigate thermally activated structural relaxation in a model amorphous solid. The…

Materials Science · Physics 2017-10-11 P. M. Derlet , R. Maass

Exa-scale simulations are on the horizon but almost no new design for the output has been proposed in recent years. In simulations using individual time steps, the traditional snapshots are over resolving particles/cells with large time…

Instrumentation and Methods for Astrophysics · Physics 2022-10-25 Loic Hausammann , Pedro Gonnet , Matthieu Schaller

In this work, we describe various improved implementations of the mapping approach to surface hopping (MASH) for simulating nonadiabatic dynamics. These include time-reversible and piecewise-continuous integrators, which is only formally…

Chemical Physics · Physics 2026-03-31 J. Amira Geuther , Kasra Asnaashari , Jeremy O. Richardson

Unraveling the dynamical motions of biomolecules is essential for bridging their structure and function, yet it remains a major computational challenge. Molecular dynamics (MD) simulation provides a detailed depiction of biomolecular…

Biomolecules · Quantitative Biology 2025-09-17 Allan dos Santos Costa , Manvitha Ponnapati , Dana Rubin , Tess Smidt , Joseph Jacobson

Motivated by the very low diffusivity recently found in ab initio simulations of liquid water, we have studied its dependence with temperature, system size, and duration of the simulations. We use ab initio molecular dynamics (AIMD),…

Soft Condensed Matter · Physics 2009-11-10 M. V. Fernandez-Serra , Emilio Artacho

Symplectic numerical schemes for reversible dynamical systems predict the solution reliably over large times as well, and are a good starting point for extension to schemes for simulating irreversible situations like viscoelastic wave…

Classical Physics · Physics 2025-07-03 Donát M. Takács , Áron Pozsár , Tamás Fülöp

We study compressible fluid flow in narrow two-dimensional channels using a novel molecular dynamics simulation method. In the simulation area, an upstream source is maintained at constant density and temperature while a downstream…

Condensed Matter · Physics 2009-10-22 M. Sun , C. Ebner

The interface between liquid water and the Pt(111) metal surface is characterized structurally and thermodynamically via reactive molecular dynamics (MD) simulations within the ReaxFF framework. The formation of a distinct buckled adsorbate…

Chemical Physics · Physics 2021-03-19 Christoph Karsten Jung , Laura Braunwarth , Andrey Sinyavskiy , Timo Jacob

Path sampling approaches have become invaluable tools to explore the mechanisms and dynamics of so-called rare events that are characterized by transitions between metastable states separated by sizeable free energy barriers. Their…

Statistical Mechanics · Physics 2022-06-08 Steven W. Hall , Grisell Díaz Leines , Sapna Sarupria , Jutta Rogal