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We present a novel multimodal language model approach for predicting molecular properties by combining chemical language representation with physicochemical features. Our approach, MULTIMODAL-MOLFORMER, utilizes a causal multistage feature…

Accurately predicting molecular properties is a challenging but essential task in drug discovery. Recently, many mono-modal deep learning methods have been successfully applied to molecular property prediction. However, the inherent…

Machine Learning · Computer Science 2024-09-16 Xiaohua Lu , Liangxu Xie , Lei Xu , Rongzhi Mao , Shan Chang , Xiaojun Xu

Accurate prediction of liquid viscosity is essential for process design and simulation, yet remains challenging for novel molecules. Conventional group-contribution models struggle with isomer discrimination, large molecules, and parameter…

Accurate molecular property prediction is central to drug discovery, catalysis, and process design, yet real-world applications are often limited by small datasets. Molecular foundation models provide a promising direction by learning…

Machine Learning · Computer Science 2026-04-21 Karim K. Ben Hicham , Jan G. Rittig , Martin Grohe , Alexander Mitsos

High-fidelity experimental characterization of turbulent premixed flames remains limited by the cost and complexity of advanced diagnostics, particularly under elevated pressures and intense turbulence where measurements of coupled flame…

Machine Learning · Computer Science 2026-05-12 Saghar Zolfaghari , Yu Xie , Junfeng Yang , Safa Jamali

Accurately predicting vapor pressure is vital for various industrial and environmental applications. However, obtaining accurate measurements for all compounds of interest is not possible due to the resource and labor intensity of…

The limited extrapolative power of structure-based machine learning (ML) models is a critical bottleneck in chemical discovery, particularly for industrial R&D, where navigating uncharted chemical space to find next-generation materials or…

The recent success of large foundation models in artificial intelligence has prompted the emergence of chemical pre-trained models. Despite the growing interest in large molecular pre-trained models that provide informative representations…

Machine Learning · Computer Science 2025-05-26 Jinho Chang , Jong Chul Ye

Over the past six years, molecular transformer models have become key tools in drug discovery. Most existing models are pre-trained on large, unlabeled datasets such as ZINC or ChEMBL. However, the extent to which large-scale pre-training…

Machine Learning · Computer Science 2025-05-23 Afnan Sultan , Max Rausch-Dupont , Shahrukh Khan , Olga Kalinina , Dietrich Klakow , Andrea Volkamer

Artificial intelligence is transforming computational materials science, improving the prediction of material properties, and accelerating the discovery of novel materials. Recently, publicly available material data repositories have grown…

Graph based molecular representation learning is essential for accurately predicting molecular properties in drug discovery and materials science; however, it faces significant challenges due to the intricate relationships among molecules…

Computational Engineering, Finance, and Science · Computer Science 2025-05-28 Zhengyang Zhou , Yunrui Li , Pengyu Hong , Hao Xu

Although multimodal fusion has made significant progress, its advancement is severely hindered by the lack of adequate evaluation benchmarks. Current fusion methods are typically evaluated on a small selection of public datasets, a limited…

Machine Learning · Computer Science 2026-05-07 Leyan Xue , Changqing Zhang , Kecheng Xue , Xiaohong Liu , Guangyu Wang , Zongbo Han

In the health domain, decisions are often based on different data modalities. Thus, when creating prediction models, multimodal fusion approaches that can extract and combine relevant features from different data modalities, can be highly…

Artificial Intelligence · Computer Science 2024-02-20 Mafalda Malafaia , Thalea Schlender , Peter A. N. Bosman , Tanja Alderliesten

Molecular property prediction is crucial for drug discovery and materials science, yet existing approaches suffer from limited interpretability, poor cross-task generalization, and lack of chemical reasoning capabilities. Traditional…

Machine Learning · Computer Science 2025-10-20 Jiaxi Zhuang , Yaorui Shi , Jue Hou , Yunong He , Mingwei Ye , Mingjun Xu , Yuming Su , Linfeng Zhang , Ying Qian , Linfeng Zhang , Guolin Ke , Hengxing Cai

Modern foundation models provide highly expressive visual representations, yet adapting them to high-resolution medical imaging remains challenging due to limited annotations and weak supervision. Mammography, in particular, is…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Nikola Jovišić , Milica Škipina , Nicola Dall'Asen , Dubravko Ćulibrk

Molecular property prediction integrates quantum chemistry, cheminformatics, and deep learning to connect molecular structure with physicochemical and biological behavior. This survey traces four complementary paradigms, including Quantum,…

The quest for accurate prediction of drug molecule properties poses a fundamental challenge in the realm of Artificial Intelligence Drug Discovery (AIDD). An effective representation of drug molecules emerges as a pivotal component in this…

Machine Learning · Computer Science 2024-04-22 Zhuoyuan Wang , Jiacong Mi , Shan Lu , Jieyue He

Pathology foundation models (PFMs) have demonstrated strong representational capabilities through self-supervised pre-training on large-scale, unannotated histopathology image datasets. However, their diverse yet opaque pretraining…

Computer Vision and Pattern Recognition · Computer Science 2025-09-15 Yuxiang Xiao , Yang Hu , Bin Li , Tianyang Zhang , Zexi Li , Huazhu Fu , Jens Rittscher , Kaixiang Yang

Sequential recommendation (SR) aims to predict users' subsequent interactions by modeling their sequential behaviors. Recent studies have explored frequency domain analysis, which effectively models periodic patterns in user sequences.…

Information Retrieval · Computer Science 2025-08-20 Ilwoong Baek , Mincheol Yoon , Seongmin Park , Jongwuk Lee

Accurate prediction of mechanical properties of steel during hot rolling processes, such as Thin Slab Direct Rolling (TSDR), remains challenging due to complex interactions among chemical compositions, processing parameters, and resultant…

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