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Traditional biomedical artificial intelligence (AI) models, designed for specific tasks or modalities, often exhibit limited flexibility in real-world deployment and struggle to utilize holistic information. Generalist AI holds the…

Foundation models (FMs) have exhibited remarkable performance across a wide range of downstream tasks in many domains. Nevertheless, general-purpose FMs often face challenges when confronted with domain-specific problems, due to their…

Computational Engineering, Finance, and Science · Computer Science 2023-08-22 Yizhen Luo , Jiahuan Zhang , Siqi Fan , Kai Yang , Yushuai Wu , Mu Qiao , Zaiqing Nie

In August 2025, OpenAI released GPT-OSS models, its first open weight large language models since GPT-2 in 2019, comprising two mixture of experts architectures with 120B and 20B parameters. We evaluated both variants against six…

Computation and Language · Computer Science 2025-12-16 Ziqian Bi , Keyu Chen , Chiung-Yi Tseng , Danyang Zhang , Tianyang Wang , Hongying Luo , Lu Chen , Junming Huang , Jibin Guan , Junfeng Hao , Xinyuan Song , Junhao Song

To advance biomedical vison-language model capabilities through scaling up, fine-tuning, and instruction tuning, develop vision-language models with improved performance in handling long text, explore strategies to efficiently adopt vision…

Artificial Intelligence · Computer Science 2025-05-26 Cheng Peng , Kai Zhang , Mengxian Lyu , Hongfang Liu , Lichao Sun , Yonghui Wu

Recent advancements in artificial intelligence (AI) have precipitated significant breakthroughs in healthcare, particularly in refining diagnostic procedures. However, previous studies have often been constrained to limited functionalities.…

Artificial Intelligence · Computer Science 2024-07-08 Asma Alkhaldi , Raneem Alnajim , Layan Alabdullatef , Rawan Alyahya , Jun Chen , Deyao Zhu , Ahmed Alsinan , Mohamed Elhoseiny

In the current landscape of artificial intelligence, foundation models serve as the bedrock for advancements in both language and vision domains. OpenAI GPT-4 has emerged as the pinnacle in large language models (LLMs), while the computer…

Computer Vision and Pattern Recognition · Computer Science 2023-11-20 Chris Kelly , Luhui Hu , Cindy Yang , Yu Tian , Deshun Yang , Bang Yang , Zaoshan Huang , Zihao Li , Yuexian Zou

Generalist Medical AI (GMAI) systems have demonstrated expert-level performance in biomedical perception tasks, yet their clinical utility remains limited by inadequate multi-modal explainability and suboptimal prognostic capabilities.…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Honglong Yang , Shanshan Song , Yi Qin , Lehan Wang , Haonan Wang , Xinpeng Ding , Qixiang Zhang , Bodong Du , Xiaomeng Li

Despite rapid advances in multimodal large language models, agricultural applications remain constrained by the lack of multilingual speech data, unified multimodal architectures, and comprehensive evaluation benchmarks. To address these…

Computation and Language · Computer Science 2025-12-12 Bo Yang , Lanfei Feng , Yunkui Chen , Yu Zhang , Jianyu Zhang , Xiao Xu , Nueraili Aierken , Shijian Li

With the emergence of large language models (LLMs) and vision foundation models, how to combine the intelligence and capacity of these open-sourced or API-available models to achieve open-world visual perception remains an open question. In…

Computer Vision and Pattern Recognition · Computer Science 2024-03-15 Chris Kelly , Luhui Hu , Bang Yang , Yu Tian , Deshun Yang , Cindy Yang , Zaoshan Huang , Zihao Li , Jiayin Hu , Yuexian Zou

Pathology images are crucial for diagnosing and managing various diseases by visualizing cellular and tissue-level abnormalities. Recent advancements in artificial intelligence (AI), particularly multimodal models like ChatGPT, have shown…

Human-Computer Interaction · Computer Science 2024-09-25 Mianxin Liu , Jianfeng Wu , Fang Yan , Hongjun Li , Wei Wang , Shaoting Zhang , Zhe Wang

We present a vision and language model named MultiModal-GPT to conduct multi-round dialogue with humans. MultiModal-GPT can follow various instructions from humans, such as generating a detailed caption, counting the number of interested…

Computer Vision and Pattern Recognition · Computer Science 2023-06-14 Tao Gong , Chengqi Lyu , Shilong Zhang , Yudong Wang , Miao Zheng , Qian Zhao , Kuikun Liu , Wenwei Zhang , Ping Luo , Kai Chen

Large language models have shown their remarkable capabilities as a general interface for various language-related applications. Motivated by this, we target to build a unified interface for completing many vision-language tasks including…

Computer Vision and Pattern Recognition · Computer Science 2023-11-08 Jun Chen , Deyao Zhu , Xiaoqian Shen , Xiang Li , Zechun Liu , Pengchuan Zhang , Raghuraman Krishnamoorthi , Vikas Chandra , Yunyang Xiong , Mohamed Elhoseiny

Medicine is inherently multimodal, with rich data modalities spanning text, imaging, genomics, and more. Generalist biomedical artificial intelligence (AI) systems that flexibly encode, integrate, and interpret this data at scale can…

Despite the excitement behind biomedical artificial intelligence (AI), access to high-quality, diverse, and large-scale data - the foundation for modern AI systems - is still a bottleneck to unlocking its full potential. To address this…

Multimodal Large Language Models (MLLMs) show promise for medical applications, yet progress in dermatology lags due to limited training data, narrow task coverage, and lack of clinically-grounded supervision that mirrors expert diagnostic…

Computation and Language · Computer Science 2026-01-06 Jinghan Ru , Siyuan Yan , Yuguo Yin , Yuexian Zou , Zongyuan Ge

Large language models such as BERT and the GPT series started a paradigm shift that calls for building general-purpose models via pre-training on large datasets, followed by fine-tuning on task-specific datasets. There is now a plethora of…

Computation and Language · Computer Science 2023-06-13 Jeremy Gwinnup , Kevin Duh

Multi-modal large language models are regarded as a crucial step towards Artificial General Intelligence (AGI) and have garnered significant interest with the emergence of ChatGPT. However, current speech-language models typically adopt the…

Computation and Language · Computer Science 2023-05-22 Dong Zhang , Shimin Li , Xin Zhang , Jun Zhan , Pengyu Wang , Yaqian Zhou , Xipeng Qiu

With the rapid development of multimodal large language models (MLLMs), especially their capabilities in visual chat through refer and ground functionalities, their significance is increasingly recognized. However, the biomedical field…

Computer Vision and Pattern Recognition · Computer Science 2024-07-01 Xiaoshuang Huang , Haifeng Huang , Lingdong Shen , Yehui Yang , Fangxin Shang , Junwei Liu , Jia Liu

Multimodal large language models have advanced rapidly, but their adoption in medicine is constrained by limited domain coverage, imperfect modality alignment, and insufficient grounded reasoning. We introduce MedMO, a medical multimodal…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Ankan Deria , Komal Kumar , Adinath Madhavrao Dukre , Eran Segal , Salman Khan , Imran Razzak

In this work, we present MedImageInsight, an open-source medical imaging embedding model. MedImageInsight is trained on medical images with associated text and labels across a diverse collection of domains, including X-Ray, CT, MRI,…

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