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Mutational signature analysis has emerged as a powerful method for uncovering the underlying biological processes driving cancer development. However, the signature extraction process, typically performed using non-negative matrix…

Applications · Statistics 2026-02-27 Ida Egendal , Rasmus Froberg Brøndum , Dan J Woodcock , Christopher Yau , Martin Bøgsted

Steering has emerged as a promising approach in controlling large language models (LLMs) without modifying model parameters. However, most existing steering methods rely on large-scale datasets to learn clear behavioral information, which…

Machine Learning · Computer Science 2025-10-06 Anyi Wang , Xuansheng Wu , Dong Shu , Yunpu Ma , Ninghao Liu

Variational AutoEncoders (VAEs) are powerful generative models that merge elements from statistics and information theory with the flexibility offered by deep neural networks to efficiently solve the generation problem for high dimensional…

Machine Learning · Computer Science 2021-03-02 A. Asperti , D. Evangelista , E. Loli Piccolomini

Vast amounts of remote sensing (RS) data provide Earth observations across multiple dimensions, encompassing critical spatial, temporal, and spectral information which is essential for addressing global-scale challenges such as land use…

Computer Vision and Pattern Recognition · Computer Science 2024-06-18 Lixian Zhang , Yi Zhao , Runmin Dong , Jinxiao Zhang , Shuai Yuan , Shilei Cao , Mengxuan Chen , Juepeng Zheng , Weijia Li , Wei Liu , Wayne Zhang , Litong Feng , Haohuan Fu

Machine learning methods provide a general framework for automatically finding and representing the essential characteristics of simulation data. This task is particularly crucial in enhanced sampling simulations. There we seek a few…

Chemical Physics · Physics 2021-07-07 Jakub Rydzewski , Omar Valsson

The ability to extract generative parameters from high-dimensional fields of data in an unsupervised manner is a highly desirable yet unrealized goal in computational physics. This work explores the use of variational autoencoders (VAEs)…

Computational Physics · Physics 2021-11-16 Christian Jacobsen , Karthik Duraisamy

Variational Autoencoders (VAEs) have become a popular approach for dimensionality reduction. However, despite their ability to identify latent low-dimensional structures embedded within high-dimensional data, these latent representations…

Machine Learning · Statistics 2020-08-27 Kaspar Märtens , Christopher Yau

We propose to utilize a variational autoencoder (VAE) for data-driven channel estimation. The underlying true and unknown channel distribution is modeled by the VAE as a conditional Gaussian distribution in a novel way, parameterized by the…

Signal Processing · Electrical Eng. & Systems 2023-04-07 Michael Baur , Benedikt Fesl , Michael Koller , Wolfgang Utschick

Variational autoencoders (VAEs) are powerful generative models with the salient ability to perform inference. Here, we introduce a quantum variational autoencoder (QVAE): a VAE whose latent generative process is implemented as a quantum…

Optical spectra contain a wealth of information about the physical properties and formation histories of galaxies. Often though, spectra are too noisy for this information to be accurately retrieved. In this study, we explore how machine…

Astrophysics of Galaxies · Physics 2023-10-17 M. Scourfield , A. Saintonge , D. de Mijolla , S. Viti

This study investigates the use of non-linear unsupervised dimensionality reduction techniques to compress a music dataset into a low-dimensional representation which can be used in turn for the synthesis of new sounds. We systematically…

Audio and Speech Processing · Electrical Eng. & Systems 2019-05-27 Fanny Roche , Thomas Hueber , Samuel Limier , Laurent Girin

Often the analysis of time-dependent chemical and biophysical systems produces high-dimensional time-series data for which it can be difficult to interpret which individual features are most salient. While recent work from our group and…

Generative Adversarial Networks (GANs) have been used in many different applications to generate realistic synthetic data. We introduce a novel GAN with Autoencoder (GAN-AE) architecture to generate synthetic samples for variable length,…

Machine Learning · Computer Science 2022-10-10 Stephanie Ger , Yegna Subramanian Jambunath , Diego Klabjan

Recent work leverages Vision Foundation Models as image encoders to boost the generative performance of latent diffusion models (LDMs), as their semantic feature distributions are easy to learn. However, such semantic features often lack…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Siyu Liu , Chujie Qin , Hubery Yin , Qixin Yan , Zheng-Peng Duan , Chen Li , Jing Lyu , Chun-Le Guo , Chongyi Li

Multimodal variational autoencoders (VAEs) have shown promise as efficient generative models for weakly-supervised data. Yet, despite their advantage of weak supervision, they exhibit a gap in generative quality compared to unimodal VAEs,…

Machine Learning · Computer Science 2022-04-08 Imant Daunhawer , Thomas M. Sutter , Kieran Chin-Cheong , Emanuele Palumbo , Julia E. Vogt

There are many problems in physics, biology, and other natural sciences in which symbolic regression can provide valuable insights and discover new laws of nature. A widespread Deep Neural Networks do not provide interpretable solutions.…

Machine Learning · Computer Science 2023-01-18 Sergei Popov , Mikhail Lazarev , Vladislav Belavin , Denis Derkach , Andrey Ustyuzhanin

In this paper, we explore the use of a variational autoencoder (VAE), a deep generative model, to compress and generate images of dark matter density fields from $\Lambda$CDM like cosmological simulations. The VAE learns a compact,…

Cosmology and Nongalactic Astrophysics · Physics 2025-07-25 Jazhiel Chacón-Lavanderos , Isidro Gómez-Vargas , Ricardo Menchaca-Mendez , J. Alberto Vázquez

Recent state-of-the-art autoencoder based generative models have an encoder-decoder structure and learn a latent representation with a pre-defined distribution that can be sampled from. Implementing the encoder networks of these models in a…

Machine Learning · Computer Science 2020-05-11 D. T. Braithwaite , M. O'Connor , W. B. Kleijn

As in many fields of medical research, survival analysis has witnessed a growing interest in the application of deep learning techniques to model complex, high-dimensional, heterogeneous, incomplete, and censored medical data. Current…

Machine Learning · Computer Science 2023-12-25 Patricia A. Apellániz , Juan Parras , Santiago Zazo

Semi-supervised learning is sought for leveraging the unlabelled data when labelled data is difficult or expensive to acquire. Deep generative models (e.g., Variational Autoencoder (VAE)) and semisupervised Generative Adversarial Networks…

Machine Learning · Computer Science 2019-05-09 Xiang Zhang , Lina Yao , Feng Yuan