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Variant effect predictors (VEPs) aim to assess the functional impact of protein variants, traditionally relying on multiple sequence alignments (MSAs). This approach assumes that naturally occurring variants are fit, an assumption…

Machine Learning · Computer Science 2025-07-04 Antoine Honoré , Borja Rodríguez Gálvez , Yoomi Park , Yitian Zhou , Volker M. Lauschke , Ming Xiao

Variational autoencoders (VAEs) are powerful tools for learning latent representations of data used in a wide range of applications. In practice, VAEs usually require multiple training rounds to choose the amount of information the latent…

Machine Learning · Computer Science 2023-08-21 Juhan Bae , Michael R. Zhang , Michael Ruan , Eric Wang , So Hasegawa , Jimmy Ba , Roger Grosse

Recently, an audio-visual speech generative model based on variational autoencoder (VAE) has been proposed, which is combined with a nonnegative matrix factorization (NMF) model for noise variance to perform unsupervised speech enhancement.…

Audio and Speech Processing · Electrical Eng. & Systems 2019-11-12 Mostafa Sadeghi , Xavier Alameda-Pineda

In recent years Variation Autoencoders have become one of the most popular unsupervised learning of complicated distributions.Variational Autoencoder (VAE) provides more efficient reconstructive performance over a traditional autoencoder.…

Machine Learning · Statistics 2017-07-12 Gautam Ramachandra

While unsupervised variational autoencoders (VAE) have become a powerful tool in neuroimage analysis, their application to supervised learning is under-explored. We aim to close this gap by proposing a unified probabilistic model for…

Machine Learning · Computer Science 2019-07-15 Qingyu Zhao , Ehsan Adeli , Nicolas Honnorat , Tuo Leng , Kilian M. Pohl

Variational auto-encoders (VAEs) are deep generative latent variable models that can be used for learning the distribution of complex data. VAEs have been successfully used to learn a probabilistic prior over speech signals, which is then…

Sound · Computer Science 2020-12-18 Mostafa Sadeghi , Simon Leglaive , Xavier Alameda-PIneda , Laurent Girin , Radu Horaud

Density estimation, compression and data generation are crucial tasks in artificial intelligence. Variational Auto-Encoders (VAEs) constitute a single framework to achieve these goals. Here, we present a novel class of generative models,…

Machine Learning · Statistics 2021-07-07 Ioannis Gatopoulos , Jakub M. Tomczak

In this work, we propose a Variational Autoencoder (VAE) - Generative Adversarial Networks (GAN) model that can produce highly realistic MRI together with its pixel accurate groundtruth for the application of cine-MR image cardiac…

Image and Video Processing · Electrical Eng. & Systems 2020-05-25 Youssef Skandarani , Nathan Painchaud , Pierre-Marc Jodoin , Alain Lalande

Deep generative models have emerged as influential instruments for data generation and manipulation. Enhancing the controllability of these models by selectively modifying data attributes has been a recent focus. Variational Autoencoders…

Image and Video Processing · Electrical Eng. & Systems 2023-12-15 Maxime Di Folco , Cosmin Bercea , Julia A. Schnabel

Deep generative models have demonstrated successful applications in learning non-linear data distributions through a number of latent variables and these models use a nonlinear function (generator) to map latent samples into the data space.…

Computer Vision and Pattern Recognition · Computer Science 2023-04-04 Pourya Shamsolmoali , Masoumeh Zareapoor , Huiyu Zhou , Dacheng Tao , Xuelong Li

Clustering high-dimensional data, such as images or biological measurements, is a long-standingproblem and has been studied extensively. Recently, Deep Clustering has gained popularity due toits flexibility in fitting the specific…

Machine Learning · Computer Science 2020-12-21 Andreas Kopf , Vincent Fortuin , Vignesh Ram Somnath , Manfred Claassen

Variational autoencoders (VAEs) have been used extensively to discover low-dimensional latent factors governing neural activity and animal behavior. However, without careful model selection, the uncovered latent factors may reflect noise in…

Machine Learning · Computer Science 2023-12-13 Julia Huiming Wang , Dexter Tsin , Tatiana Engel

Deep generative models often perform poorly in real-world applications due to the heterogeneity of natural data sets. Heterogeneity arises from data containing different types of features (categorical, ordinal, continuous, etc.) and…

Machine Learning · Computer Science 2020-06-23 Chao Ma , Sebastian Tschiatschek , José Miguel Hernández-Lobato , Richard Turner , Cheng Zhang

In this paper we introduce a recurrent neural network (RNN) based variational autoencoder (VAE) model with a new constrained loss function that can generate more meaningful electroencephalography (EEG) features from raw EEG features to…

Audio and Speech Processing · Electrical Eng. & Systems 2020-06-05 Gautam Krishna , Co Tran , Mason Carnahan , Ahmed Tewfik

We present a novel introspective variational autoencoder (IntroVAE) model for synthesizing high-resolution photographic images. IntroVAE is capable of self-evaluating the quality of its generated samples and improving itself accordingly.…

Machine Learning · Computer Science 2018-10-30 Huaibo Huang , Zhihang Li , Ran He , Zhenan Sun , Tieniu Tan

Purpose: Handling heterogeneous and mixed data types has become increasingly critical with the exponential growth in real-world databases. While deep generative models attempt to merge diverse data views into a common latent space, they…

Machine Learning · Computer Science 2024-10-23 Alejandro Guerrero-López , Carlos Sevilla-Salcedo , Vanessa Gómez-Verdejo , Pablo M. Olmos

Generative models have emerged as powerful tools in medical imaging, enabling tasks such as segmentation, anomaly detection, and high-quality synthetic data generation. These models typically rely on learning meaningful latent…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Jordi Malé , Juan Fortea , Mateus Rozalem-Aranha , Neus Martínez-Abadías , Xavier Sevillano

Although variational autoencoders (VAEs) represent a widely influential deep generative model, many aspects of the underlying energy function remain poorly understood. In particular, it is commonly believed that Gaussian encoder/decoder…

Machine Learning · Computer Science 2019-10-31 Bin Dai , David Wipf

Variational Autoencoder (VAE) and its variations are classic generative models by learning a low-dimensional latent representation to satisfy some prior distribution (e.g., Gaussian distribution). Their advantages over GAN are that they can…

Computer Vision and Pattern Recognition · Computer Science 2020-09-24 Cong Geng , Jia Wang , Li Chen , Zhiyong Gao

Multi-component datasets with intricate dependencies, like industrial assemblies or multi-modal imaging, challenge current generative modeling techniques. Existing Multi-component Variational AutoEncoders typically rely on simplified…

Machine Learning · Computer Science 2026-04-07 Fouad Oubari , Mohamed El-Baha , Raphael Meunier , Rodrigue Décatoire , Mathilde Mougeot