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AlphaFold has achieved groundbreaking advancements in protein structure prediction, exerting profound influence across biology, medicine, and drug discovery. However, its reliance on multiple sequence alignment (MSA) is inherently…

Quantum Physics · Physics 2025-06-03 Rong Chen , Quan-Xin Mei , Wen-Ding Zhao , Lin Yao , Hao-Xiang Yang , Shun-Yao Zhang , Jiao Chen , Hong-Lin Li

Quadratic Unconstrained Binary Optimization (QUBO) is recognized as a unifying framework for modeling a wide range of problems. Problems can be solved with commercial solvers customized for solving QUBO and since QUBO have degree two, it is…

Optimization and Control · Mathematics 2021-07-27 Amit Verma , Mark Lewis , Gary Kochenberger

The utilization of universal frequency reuse in multi-beam satellite systems introduces a non-negligible level of co-channel interference (CCI), which in turn penalizes the quality of service experienced by users. Taking this as starting…

Information Theory · Computer Science 2016-11-15 Vincent Boussemart , Loris Marini , Matteo Berioli

Quantum Approximate Optimization Algorithm (QAOA) and Quantum Annealing are prominent approaches for solving combinatorial optimization problems, such as those formulated as Quadratic Unconstrained Binary Optimization (QUBO). These…

Encoding combinatorial optimization problems into physically meaningful Hamiltonians with tractable energy landscapes forms the foundation of quantum optimization. Numerous works have studied such efficient encodings for the class of…

Quantum Physics · Physics 2026-02-12 Sebastian Egginger , Kristina Kirova , Sonja Bruckner , Stefan Hillmich , Richard Kueng

Present-day quantum systems face critical bottlenecks, including limited qubit counts, brief coherence intervals, and high susceptibility to errors-all of which obstruct the execution of large and complex circuits. The advancement of…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-06-13 Waylon Luo , Jiapeng Zhao , Tong Zhan , Qiang Guan

The advent of quantum computing can potentially revolutionize how complex problems are solved. This paper proposes a two-loop quantum-classical solution algorithm for generation scheduling by infusing quantum computing, machine learning,…

Quantum Physics · Physics 2023-05-18 Reza Mahroo , Amin Kargarian

Optimization problems is one of the most challenging applications of quantum computers, as well as one of the most relevants. As a consequence, it has attracted huge efforts to obtain a speedup over classical algorithms using quantum…

Quadratic unconstrained binary optimization (QUBO) has become the standard format for optimization using quantum computers, i.e., for both the quantum approximate optimization algorithm (QAOA) and quantum annealing (QA). We present a…

Quantum Physics · Physics 2022-04-26 Thomas Gabor , Marian Lingsch Rosenfeld , Sebastian Feld , Claudia Linnhoff-Popien

Constraint handling remains a key bottleneck in quantum combinatorial optimization. While slack-variable-based encodings are straightforward, they significantly increase qubit counts and circuit depth, challenging the scalability of quantum…

Quantum Physics · Physics 2025-08-12 Monit Sharma , Hoong Chuin Lau

Many real-world problems are naturally formulated as higher-order optimization (HUBO) tasks involving dense, multi-variable interactions, which are challenging to solve with classical methods. Quantum optimization offers a promising route,…

Quantum Annealing (QA) and QAOA are promising quantum optimisation algorithms used for finding approximate solutions to combinatorial problems on near-term NISQ systems. Many NP-hard problems can be reformulated as Quadratic Unconstrained…

Quantum Physics · Physics 2025-10-06 Namasi G Sankar , Georgios Miliotis , Simon Caton

The routing and wavelength assignment with protection is an important problem in telecommunications. Given an optical network and incoming connection requests, a commonly studied variant of the problem aims to grant maximum number of…

Optimization and Control · Mathematics 2021-06-09 Oylum Şeker , Merve Bodur , Hamed Pouya

The Traveling Salesman Problem (TSP) is a fundamental challenge in combinatorial optimization, widely applied in logistics and transportation. As the size of TSP instances grows, traditional algorithms often struggle to produce high-quality…

We introduce a novel approach to translate arbitrary 3-SAT instances to Quadratic Unconstrained Binary Optimization (QUBO) as they are used by quantum annealing (QA) or the quantum approximate optimization algorithm (QAOA). Our approach…

Quantum networks rely on high-fidelity entanglement links, but achieving target fidelity often increases latency and Bell pair consumption due to purification. This paper proposes a cost-based scheduler that jointly optimizes path selection…

Quantum Physics · Physics 2026-03-04 Gongyu Ni , Holger Claussen , Lester Ho

This paper studies quantum optimization baselines for the Generalized Traveling Salesman Problem (GTSP), a clustered routing problem that naturally models variant selection and sequencing problems under discrete alternatives. We propose a…

Towards the development of 6G mobile networks, it is promising to integrate a large number of devices from multi-dimensional platforms, and it is crucial to have a solid understanding of the theoretical limits of large-scale networks. We…

Information Theory · Computer Science 2025-09-19 Yanxiao Liu , Shenghao Yang , Cheuk Ting Li

Quantum federated learning (QFL) combines the robust data processing of quantum computing with the privacy-preserving features of federated learning (FL). However, in large-scale wireless networks, optimizing sum-rate is crucial for…

Information Theory · Computer Science 2026-03-03 Shaba Shaon , Christopher G. Brinton , Dinh C. Nguyen

Numerous established machine learning models and various neural network architectures can be restructured as Quadratic Unconstrained Binary Optimization (QUBO) problems. A significant challenge in Adiabatic Quantum Machine Learning (AQML)…

Quantum Physics · Physics 2025-05-15 Bahram Alidaee , Haibo Wang , Lutfu Sua , Wade Liu