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The highly influential two-group model in testing a large number of statistical hypotheses assumes that the test statistics are drawn independently from a mixture of a high probability null distribution and a low probability alternative.…

Methodology · Statistics 2020-12-08 Ruth Heller , Saharon Rosset

The steep rise in availability and usage of high-throughput technologies in biology brought with it a clear need for methods to control the False Discovery Rate (FDR) in multiple tests. Benjamini and Hochberg (BH) introduced in 1995 a…

Methodology · Statistics 2011-08-11 Amit Zeisel , Or Zuk , Eytan Domany

Density ratio estimation (DRE) is a core technique in machine learning used to capture relationships between two probability distributions. $f$-divergence loss functions, which are derived from variational representations of $f$-divergence,…

Machine Learning · Computer Science 2025-03-18 Yoshiaki Kitazawa

For multiple testing, we introduce Storey-type FDR procedures and the concept of "regular estimator of the proportion of true nulls". We show that the rejection threshold of a Storey-type FDR procedure is a stopping time with respect to the…

Statistics Theory · Mathematics 2016-06-30 Xiongzhi Chen , R. W. Doerge

Recent studies have shown that deep learning models are vulnerable to membership inference attacks (MIAs), which aim to infer whether a data record was used to train a target model or not. To analyze and study these vulnerabilities, various…

Machine Learning · Statistics 2025-08-12 Chenxu Zhao , Wei Qian , Aobo Chen , Mengdi Huai

We investigate theoretical guarantees for the false-negative rate (FNR) -- the fraction of true causal edges whose orientation is not recovered, under single-variable random interventions and an $\epsilon$-interventional faithfulness…

Machine Learning · Computer Science 2025-11-05 Mathieu Chevalley , Arash Mehrjou , Patrick Schwab

A new online multiple testing procedure is described in the context of anomaly detection, which controls the False Discovery Rate (FDR). An accurate anomaly detector must control the false positive rate at a prescribed level while keeping…

Methodology · Statistics 2024-12-17 Etienne Krönert , Alain Célisse , Dalila Hattab

This paper introduces a novel conformal selection procedure, inspired by the Neyman--Pearson paradigm, to maximize the power of selecting qualified units while maintaining false discovery rate (FDR) control. Existing conformal selection…

Methodology · Statistics 2025-02-25 Jing Qin , Yukun Liu , Moming Li , Chiung-Yu Huang

We develop the distribution of the number of hypotheses found to be statistically significant using the rule from Benjamini and Hochberg (1995) for controlling the false discovery rate (FDR). This distribution has both a small sample form…

Methodology · Statistics 2018-02-27 Chang Yu , Daniel Zelterman

Controlling False Discovery Rate (FDR) while leveraging the side information of multiple hypothesis testing is an emerging research topic in modern data science. Existing methods rely on the test-level covariates while ignoring metrics…

Machine Learning · Statistics 2022-10-10 Lin Qiu , Nils Murrugarra-Llerena , Vítor Silva , Lin Lin , Vernon M. Chinchilli

Online testing procedures assume that hypotheses are observed in sequence, and allow the significance thresholds for upcoming tests to depend on the test statistics observed so far. Some of the most popular online methods include alpha…

Methodology · Statistics 2022-02-11 Aaron Fisher

Why do language models trained on contradictory data prefer correct answers? In controlled experiments with small transformers (3.5M--86M parameters), we show that this preference tracks the compressibility structure of errors rather than…

Computation and Language · Computer Science 2026-04-07 Konstantin Krestnikov

Distributional reinforcement learning (DRL) enhances the understanding of the effects of the randomness in the environment by letting agents learn the distribution of a random return, rather than its expected value as in standard…

Optimization and Control · Mathematics 2024-03-26 Zifan Wang , Yulong Gao , Siyi Wang , Michael M. Zavlanos , Alessandro Abate , Karl H. Johansson

There has been a misconception that only one type of error rate control is necessary in clinical trials, leading to debates over whether to prioritize Familywise Error Rate (FWER) or False Discovery Rate (FDR). This misconception has led to…

Methodology · Statistics 2026-03-26 Xinping Cui , Emily Ouyang , Yi Liu , Jingjing Yan Schneider , Hong Tian , Bushi Wang , Jason C. Hsu

Effectively controlling the false discovery rate (FDR) in high-dimensional variable selection is a fundamental statistical problem that has garnered significant research interest. In this paper, we propose a novel, user-friendly, and…

Methodology · Statistics 2026-04-28 Yujia Wu , Panxu Yuan , Binyan Jiang

The Fisher-Rao distance is the geodesic distance between probability distributions in a statistical manifold equipped with the Fisher metric, which is a natural choice of Riemannian metric on such manifolds. It has recently been applied to…

Statistics Theory · Mathematics 2024-09-25 Henrique K. Miyamoto , Fábio C. C. Meneghetti , Julianna Pinele , Sueli I. R. Costa

By restricting the possible values of the proportion of null hypotheses that are true, the local false discovery rate (LFDR) can be estimated using as few as one comparison. The proportion of proteins with equivalent abundance was estimated…

Methodology · Statistics 2011-05-13 David R. Bickel

Addressing the simultaneous identification of contributory variables while controlling the false discovery rate (FDR) in high-dimensional data is a crucial statistical challenge. In this paper, we propose a novel model-free variable…

Methodology · Statistics 2024-04-23 Yixin Han , Xu Guo , Changliang Zou

For multiple testing based on p-values with c\`{a}dl\`{a}g distribution functions, we propose an FDR procedure "BH+" with proven conservativeness. BH+ is at least as powerful as the BH procedure when they are applied to super-uniform…

Methodology · Statistics 2020-03-09 Xiongzhi Chen

Publication bias and p-hacking are two well-known phenomena that strongly affect the scientific literature and cause severe problems in meta-analyses. Due to these phenomena, the assumptions of meta-analyses are seriously violated and the…

Methodology · Statistics 2020-02-26 Jonas Moss , Riccardo De Bin
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