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Molecular language modeling is an effective approach to generating novel chemical structures. However, these models do not \emph{a priori} encode certain preferences a chemist may desire. We investigate the use of fine-tuning using Direct…

Machine Learning · Statistics 2023-10-20 Ryan Park , Ryan Theisen , Navriti Sahni , Marcel Patek , Anna Cichońska , Rayees Rahman

Adapting large language models (LLMs) for specific tasks usually involves fine-tuning through reinforcement learning with human feedback (RLHF) on preference data. While these data often come from diverse labelers' groups (e.g., different…

Computation and Language · Computer Science 2024-05-31 Shyam Sundhar Ramesh , Yifan Hu , Iason Chaimalas , Viraj Mehta , Pier Giuseppe Sessa , Haitham Bou Ammar , Ilija Bogunovic

We present a multi-objective binder design paradigm based on instruction fine-tuning and direct preference optimization (DPO) of autoregressive protein language models (pLMs). Multiple design objectives are encoded in the language model…

Biological Physics · Physics 2024-03-08 Pouria Mistani , Venkatesh Mysore

Direct Preference Optimization (DPO) has become a widely used training method for the instruction fine-tuning of large language models (LLMs). In this work, we explore an under-investigated aspect of DPO - its dependency on the reference…

Computation and Language · Computer Science 2024-08-23 Yixin Liu , Pengfei Liu , Arman Cohan

Preference optimization techniques have become a standard final stage for training state-of-art large language models (LLMs). However, despite widespread adoption, the vast majority of work to-date has focused on first-class citizen…

Computation and Language · Computer Science 2024-07-04 John Dang , Arash Ahmadian , Kelly Marchisio , Julia Kreutzer , Ahmet Üstün , Sara Hooker

Automated negotiation in complex, multi-party and multi-issue settings critically depends on accurate opponent modeling. However, conventional numerical-only approaches fail to capture the qualitative information embedded in natural…

Direct preference optimization (DPO) is a successful fine-tuning strategy for aligning large language models with human preferences without the need to train a reward model or employ reinforcement learning. DPO, as originally formulated,…

Computation and Language · Computer Science 2024-06-07 Afra Amini , Tim Vieira , Ryan Cotterell

Large language models (LLMs), despite their extensive pretraining on diverse datasets, require effective alignment to human preferences for practical and reliable deployment. Conventional alignment methods typically employ off-policy…

Computation and Language · Computer Science 2025-07-29 Hyeonji Lee , Daejin Jo , Seohwan Yun , Sungwoong Kim

We study how data of higher quality can be leveraged to improve performance in Direct Preference Optimization (DPO), aiming to understand its impact on DPO training dynamics. Our analyses show that both the solution space and the…

Machine Learning · Computer Science 2025-10-14 Kyung Rok Kim , Yumo Bai , Chonghuan Wang , Guanting Chen

Preference learning is a key technology for aligning language models with human values. Reinforcement Learning from Human Feedback (RLHF) is a model-based algorithm to optimize preference learning, which first fits a reward model for…

Machine Learning · Computer Science 2024-03-26 Zaifan Jiang , Xing Huang , Chao Wei

Direct Preference Optimization (DPO) has been proposed as an effective and efficient alternative to reinforcement learning from human feedback (RLHF). In this paper, we propose a novel and enhanced version of DPO based on curriculum…

Computer Vision and Pattern Recognition · Computer Science 2025-05-12 Florinel-Alin Croitoru , Vlad Hondru , Radu Tudor Ionescu , Nicu Sebe , Mubarak Shah

This study addresses the challenge of noise in training datasets for Direct Preference Optimization (DPO), a method for aligning Large Language Models (LLMs) with human preferences. We categorize noise into pointwise noise, which includes…

Machine Learning · Computer Science 2025-04-21 Junkang Wu , Yuexiang Xie , Zhengyi Yang , Jiancan Wu , Jiawei Chen , Jinyang Gao , Bolin Ding , Xiang Wang , Xiangnan He

As Large Language Models (LLMs) demonstrate remarkable capabilities learned from vast corpora, concerns regarding data privacy and safety are receiving increasing attention. LLM unlearning, which aims to remove the influence of specific…

Machine Learning · Computer Science 2025-10-07 Kai Qin , Jiaqi Wu , Jianxiang He , Haoyuan Sun , Yifei Zhao , Bin Liang , Yongzhe Chang , Tiantian Zhang , Houde Liu

Existing open-source multimodal large language models (MLLMs) generally follow a training process involving pre-training and supervised fine-tuning. However, these models suffer from distribution shifts, which limit their multimodal…

Computation and Language · Computer Science 2025-04-08 Weiyun Wang , Zhe Chen , Wenhai Wang , Yue Cao , Yangzhou Liu , Zhangwei Gao , Jinguo Zhu , Xizhou Zhu , Lewei Lu , Yu Qiao , Jifeng Dai

Minimum Bayes Risk (MBR) decoding can significantly improve translation performance of Multilingual Large Language Models (MLLMs). However, MBR decoding is computationally expensive. We show how the recently developed Reinforcement Learning…

Computation and Language · Computer Science 2024-04-15 Guangyu Yang , Jinghong Chen , Weizhe Lin , Bill Byrne

Fine-grained video captioning aims to generate detailed, temporally coherent descriptions of video content. However, existing methods struggle to capture subtle video dynamics and rich detailed information. In this paper, we leverage…

Artificial Intelligence · Computer Science 2026-03-24 Jisheng Dang , Yizhou Zhang , Hao Ye , Teng Wang , Siming Chen , Huicheng Zheng , Yulan Guo , Jianhuang Lai , Bin Hu

Recent advancements in post-training methodologies for large language models (LLMs) have highlighted reinforcement learning (RL) as a critical component for enhancing reasoning. However, the substantial computational costs associated with…

Computation and Language · Computer Science 2025-07-29 Songjun Tu , Jiahao Lin , Xiangyu Tian , Qichao Zhang , Linjing Li , Yuqian Fu , Nan Xu , Wei He , Xiangyuan Lan , Dongmei Jiang , Dongbin Zhao

Iterative preference optimization has recently become one of the de-facto training paradigms for large language models (LLMs), but the performance is still underwhelming due to too much noisy preference data yielded in the loop. To combat…

Computation and Language · Computer Science 2024-09-18 Jianing Wang , Yang Zhou , Xiaocheng Zhang , Mengjiao Bao , Peng Yan

What enables large language models (LLMs) to effectively model user preferences in sequential recommendation? Our investigation reveals that existing preference-alignment approaches largely rely on binary pairwise comparisons, overlooking…

Information Retrieval · Computer Science 2026-04-20 Zhongyu Ouyang , Qianlong Wen , Chunhui Zhang , Yanfang Ye , Soroush Vosoughi

Aligning large language models (LLMs) with human preferences remains a key challenge in AI. Preference-based optimization methods, such as Reinforcement Learning with Human Feedback (RLHF) and Direct Preference Optimization (DPO), rely on…

Computation and Language · Computer Science 2025-05-26 Xuan Qi , Jiahao Qiu , Xinzhe Juan , Yue Wu , Mengdi Wang
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