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Fundus imaging is a critical tool in ophthalmology, with different imaging modalities offering unique advantages. For instance, fundus fluorescein angiography (FFA) can accurately identify eye diseases. However, traditional invasive FFA…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Chengzhou Yu , Huihui Fang , Hongqiu Wang , Ting Deng , Qing Du , Yanwu Xu , Weihua Yang

Recent progress with conditional image diffusion models has been stunning, and this holds true whether we are speaking about models conditioned on a text description, a scene layout, or a sketch. Unconditional image diffusion models are…

Computer Vision and Pattern Recognition · Computer Science 2023-06-22 William Harvey , Frank Wood

We introduce a new technique for generating retinal fundus images that have anatomically accurate vascular structures, using diffusion models. We generate artery/vein masks to create the vascular structure, which we then condition to…

Image and Video Processing · Electrical Eng. & Systems 2023-05-12 Sojung Go , Younghoon Ji , Sang Jun Park , Soochahn Lee

Diffusion models have shown an impressive ability to model complex data distributions, with several key advantages over GANs, such as stable training, better coverage of the training distribution's modes, and the ability to solve inverse…

Computer Vision and Pattern Recognition · Computer Science 2024-06-12 Yinbo Chen , Oliver Wang , Richard Zhang , Eli Shechtman , Xiaolong Wang , Michael Gharbi

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insufficient insulin production or impaired insulin utilization. One of its most severe complications is diabetic retinopathy (DR), a…

Image and Video Processing · Electrical Eng. & Systems 2026-02-12 Ali El Bellaj , Aya Benradi , Salman El Youssoufi , Taha El Marzouki , Mohammed-Amine Cheddadi

Purpose To develop a computer based method for the automated assessment of image quality in the context of diabetic retinopathy (DR) to guide the photographer. Methods A deep learning framework was trained to grade the images automatically.…

Computer Vision and Pattern Recognition · Computer Science 2017-03-08 Sajib Kumar Saha , Basura Fernando , Jorge Cuadros , Di Xiao , Yogesan Kanagasingam

Conditional diffusion probabilistic models can model the distribution of natural images and can generate diverse and realistic samples based on given conditions. However, oftentimes their results can be unrealistic with observable color…

Computer Vision and Pattern Recognition · Computer Science 2022-12-15 Kangfu Mei , Nithin Gopalakrishnan Nair , Vishal M. Patel

Conventional class-guided diffusion models generally succeed in generating images with correct semantic content, but often struggle with texture details. This limitation stems from the usage of class priors, which only provide coarse and…

Computer Vision and Pattern Recognition · Computer Science 2024-10-14 Xiaoyu Yue , Zidong Wang , Zeyu Lu , Shuyang Sun , Meng Wei , Wanli Ouyang , Lei Bai , Luping Zhou

This work presents a novel label-efficient selfsupervised representation learning-based approach for classifying diabetic retinopathy (DR) images in cross-domain settings. Most of the existing DR image classification methods are based on…

Image and Video Processing · Electrical Eng. & Systems 2023-04-25 Ekta Gupta , Varun Gupta , Muskaan Chopra , Prakash Chandra Chhipa , Marcus Liwicki

Alzheimers disease progresses slowly and involves complex interaction between various biological factors. Longitudinal medical imaging data can capture this progression over time. However, longitudinal data frequently encounter issues such…

Computer Vision and Pattern Recognition · Computer Science 2024-11-12 Duy-Phuong Dao , Hyung-Jeong Yang , Jahae Kim

Diabetic retinopathy (DR) is a complication of diabetes that severely affects eyes. It can be graded into five levels of severity according to international protocol. However, optimizing a grading model to have strong generalizability…

Image and Video Processing · Electrical Eng. & Systems 2020-12-22 Yi Zhou , Boyang Wang , Xiaodong He , Shanshan Cui , Ling Shao

A wide range of applications require learning image generation models whose latent space effectively captures the high-level factors of variation present in the data distribution. The extent to which a model represents such variations…

Computer Vision and Pattern Recognition · Computer Science 2021-11-09 Avinandan Bose , Aniket Das , Yatin Dandi , Piyush Rai

Convolutional Neural Networks (CNNs) have successfully been used to classify diabetic retinopathy (DR) fundus images in recent times. However, deeper representations in CNNs may capture higher-level semantics at the expense of spatial…

Computer Vision and Pattern Recognition · Computer Science 2021-02-03 Samuel Ofosu Mensah , Bubacarr Bah , Willie Brink

Classifier-free guided diffusion models have recently been shown to be highly effective at high-resolution image generation, and they have been widely used in large-scale diffusion frameworks including DALLE-2, Stable Diffusion and Imagen.…

Computer Vision and Pattern Recognition · Computer Science 2023-04-14 Chenlin Meng , Robin Rombach , Ruiqi Gao , Diederik P. Kingma , Stefano Ermon , Jonathan Ho , Tim Salimans

Recent advances in diffusion models have shown remarkable potential in the conditional generation of novel molecules. These models can be guided in two ways: (i) explicitly, through additional features representing the condition, or (ii)…

Machine Learning · Computer Science 2025-03-12 Yuchen Shen , Chenhao Zhang , Sijie Fu , Chenghui Zhou , Newell Washburn , Barnabás Póczos

We propose a novel diffusion-based image generation method called the observation-guided diffusion probabilistic model (OGDM), which effectively addresses the tradeoff between quality control and fast sampling. Our approach reestablishes…

Machine Learning · Computer Science 2024-04-02 Junoh Kang , Jinyoung Choi , Sungik Choi , Bohyung Han

Applying machine learning to real-world medical data, e.g. from hospital archives, has the potential to revolutionize disease detection in brain images. However, detecting pathology in such heterogeneous cohorts is a difficult challenge.…

Image and Video Processing · Electrical Eng. & Systems 2025-08-06 Ana Lawry Aguila , Ayodeji Ijishakin , Juan Eugenio Iglesias , Tomomi Takenaga , Yukihiro Nomura , Takeharu Yoshikawa , Osamu Abe , Shouhei Hanaoka

We introduce nested diffusion models, an efficient and powerful hierarchical generative framework that substantially enhances the generation quality of diffusion models, particularly for images of complex scenes. Our approach employs a…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Xiao Zhang , Ruoxi Jiang , Rebecca Willett , Michael Maire

Prognostic models aim to predict the future course of a disease or condition and are a vital component of personalized medicine. Statistical models make use of longitudinal data to capture the temporal aspect of disease progression;…

Machine Learning · Computer Science 2020-07-13 Joshua Bridge , Simon P. Harding , Yalin Zheng

Recent advances in Diffusion Probabilistic Models (DPMs) have set new standards in high-quality image synthesis. Yet, controlled generation remains challenging, particularly in sensitive areas such as medical imaging. Medical images feature…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Sarah Cechnicka , Matthew Baugh , Weitong Zhang , Mischa Dombrowski , Zhe Li , Johannes C. Paetzold , Candice Roufosse , Bernhard Kainz