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Recent years have seen rapid progress at the intersection between causality and machine learning. Motivated by scientific applications involving high-dimensional data, in particular in biomedicine, we propose a deep neural architecture for…

Machine Learning · Computer Science 2022-12-12 Kai Lagemann , Christian Lagemann , Bernd Taschler , Sach Mukherjee

Causal approaches to post-hoc explainability for black-box prediction models (e.g., deep neural networks trained on image pixel data) have become increasingly popular. However, existing approaches have two important shortcomings: (i) the…

Machine Learning · Computer Science 2025-08-12 Numair Sani , Daniel Malinsky , Ilya Shpitser

To draw scientifically meaningful conclusions and build reliable models of quantitative phenomena, cause and effect must be taken into consideration (either implicitly or explicitly). This is particularly challenging when the measurements…

Machine Learning · Computer Science 2020-12-11 Max A. Little , Reham Badawy

Causal inference is a science with multi-disciplinary evolution and applications. On the one hand, it measures effects of treatments in observational data based on experimental designs and rigorous statistical inference to draw causal…

Methodology · Statistics 2022-09-05 Jingying Zeng , Run Wang

We present a workflow for clinical data analysis that relies on Bayesian Structure Learning (BSL), an unsupervised learning approach, robust to noise and biases, that allows to incorporate prior medical knowledge into the learning process…

Machine Learning · Computer Science 2022-10-12 Elisa Ferrari , Luna Gargani , Greta Barbieri , Lorenzo Ghiadoni , Francesco Faita , Davide Bacciu

The increasing capture and analysis of large-scale longitudinal health data offer opportunities to improve healthcare and advance medical understanding. However, a critical gap exists between (a) -- the observation of patterns and…

Human-Computer Interaction · Computer Science 2025-08-26 Arran Zeyu Wang , David Borland , David Gotz

With the increasing adoption of predictive models trained using machine learning across a wide range of high-stakes applications, e.g., health care, security, criminal justice, finance, and education, there is a growing need for effective…

Machine Learning · Computer Science 2020-08-04 Aria Khademi , Vasant Honavar

Research in Cognitive Science suggests that humans understand and represent knowledge of the world through causal relationships. In addition to observations, they can rely on experimenting and counterfactual reasoning -- i.e. referring to…

Artificial Intelligence · Computer Science 2021-05-24 Kanvaly Fadiga , Etienne Houzé , Ada Diaconescu , Jean-Louis Dessalles

Deep generative models have shown tremendous capability in data density estimation and data generation from finite samples. While these models have shown impressive performance by learning correlations among features in the data, some…

Machine Learning · Computer Science 2024-05-24 Aneesh Komanduri , Xintao Wu , Yongkai Wu , Feng Chen

Causal learning has long concerned itself with the accurate recovery of underlying causal mechanisms. Such causal modelling enables better explanations of out-of-distribution data. Prior works on causal learning assume that the high-level…

Analysts often make visual causal inferences about possible data-generating models. However, visual analytics (VA) software tends to leave these models implicit in the mind of the analyst, which casts doubt on the statistical validity of…

Human-Computer Interaction · Computer Science 2021-07-29 Alex Kale , Yifan Wu , Jessica Hullman

How do we learn from biased data? Historical datasets often reflect historical prejudices; sensitive or protected attributes may affect the observed treatments and outcomes. Classification algorithms tasked with predicting outcomes…

Machine Learning · Computer Science 2018-12-04 David Madras , Elliot Creager , Toniann Pitassi , Richard Zemel

Causal terminology is often introduced in the interpretation of encoding and decoding models trained on neuroimaging data. In this article, we investigate which causal statements are warranted and which ones are not supported by empirical…

Current clinical decision support systems (CDSSs) typically base their predictions on correlation, not causation. In recent years, causal machine learning (ML) has emerged as a promising way to improve decision-making with CDSSs by offering…

Human-Computer Interaction · Computer Science 2026-04-17 Domenique Zipperling , Lukas Schmidt , Benedikt Hahn , Niklas Kühl , Steven Kimbrough

The discovery of causal relationships from high-dimensional data is a major open problem in bioinformatics. Machine learning and feature attribution models have shown great promise in this context but lack causal interpretation. Here, we…

Machine Learning · Computer Science 2023-04-26 Payam Dibaeinia , Saurabh Sinha

Modern deep learning models excel at pattern recognition but remain fundamentally limited by their reliance on spurious correlations, leading to poor generalization and a demand for massive datasets. We argue that a key ingredient for…

Machine Learning · Computer Science 2025-09-17 Mohamed Zayaan S

Causal inference is a statistical paradigm for quantifying causal effects using observational data. It is a complex process, requiring multiple steps, iterations, and collaborations with domain experts. Analysts often rely on visualizations…

Human-Computer Interaction · Computer Science 2023-03-02 Grace Guo , Ehud Karavani , Alex Endert , Bum Chul Kwon

Concept Bottleneck Models (CBMs) in medical imaging aim to improve model interpretability by predicting intermediate clinical concepts before final diagnoses. However, most existing CBMs treat concepts as discriminative predictors of…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Amy Rafferty , Rishi Ramaesh , Ajitha Rajan

Medical image analysis is a vibrant research area that offers doctors and medical practitioners invaluable insight and the ability to accurately diagnose and monitor disease. Machine learning provides an additional boost for this area.…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 Athanasios Vlontzos , Daniel Rueckert , Bernhard Kainz

Recent years have witnessed the rapid growth of machine learning in a wide range of fields such as image recognition, text classification, credit scoring prediction, recommendation system, etc. In spite of their great performance in…

Machine Learning · Computer Science 2021-09-20 Guandong Xu , Tri Dung Duong , Qian Li , Shaowu Liu , Xianzhi Wang