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Visual spatial intelligence is critical for medical image interpretation, yet remains largely unexplored in Multimodal Large Language Models (MLLMs) for 3D imaging. This gap persists due to a systemic lack of datasets featuring structured…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Quoc-Huy Trinh , Xi Ding , Yang Liu , Zhenyue Qin , Xingjian Li , Gorkem Durak , Halil Ertugrul Aktas , Elif Keles , Ulas Bagci , Min Xu

Accurate and interpretable multi-disease diagnosis remains a critical challenge in medical research, particularly when leveraging heterogeneous multimodal medical data. Current approaches often rely on single-modal data, limiting their…

Image and Video Processing · Electrical Eng. & Systems 2025-06-25 Yuting Zhang , Kaishen Yuan , Hao Lu , Yutao Yue , Jintai Chen , Kaishun Wu

We explore Multimodal Large Language Models (MLLMs), which integrate LLMs like GPT-4 to handle multimodal data, including text, images, audio, and more. MLLMs demonstrate capabilities such as generating image captions and answering…

Computation and Language · Computer Science 2025-01-09 Shezheng Song , Xiaopeng Li , Shasha Li , Shan Zhao , Jie Yu , Jun Ma , Xiaoguang Mao , Weimin Zhang

The integration of vision-language modalities has been a significant focus in multimodal learning, traditionally relying on Vision-Language Pretrained Models. However, with the advent of Large Language Models (LLMs), there has been a…

Computer Vision and Pattern Recognition · Computer Science 2025-02-05 Xiaorui Ma , Haoran Xie , S. Joe Qin

English-based Vision-Language Pre-training (VLP) has achieved great success in various downstream tasks. Some efforts have been taken to generalize this success to non-English languages through Multilingual Vision-Language Pre-training…

Computation and Language · Computer Science 2022-06-23 Liang Zhang , Anwen Hu , Qin Jin

Recent advancements in biology and chemistry have leveraged multi-modal learning, integrating molecules and their natural language descriptions to enhance drug discovery. However, current pre-training frameworks are limited to two…

Machine Learning · Computer Science 2025-02-05 Teng Xiao , Chao Cui , Huaisheng Zhu , Vasant G. Honavar

Multimodal Large Language Models (MLLMs) demonstrate exceptional semantic reasoning but struggle with 3D spatial perception when restricted to pure RGB inputs. Despite leveraging implicit geometric priors from 3D reconstruction models,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Jiaxin Zhang , Junjun Jiang , Haijie Li , Youyu Chen , Kui Jiang , Dave Zhenyu Chen

Medical image segmentation allows quantifying target structure size and shape, aiding in disease diagnosis, prognosis, surgery planning, and comprehension.Building upon recent advancements in foundation Vision-Language Models (VLMs) from…

Computer Vision and Pattern Recognition · Computer Science 2024-06-21 Kanchan Poudel , Manish Dhakal , Prasiddha Bhandari , Rabin Adhikari , Safal Thapaliya , Bishesh Khanal

Human expertise in chemistry and biomedicine relies on contextual molecular understanding, a capability that large language models (LLMs) can extend through fine-grained alignment between molecular structures and text. Recent multimodal…

Computation and Language · Computer Science 2025-03-10 Sumin Ha , Jun Hyeong Kim , Yinhua Piao , Sun Kim

Medical decision-making requires integrating diverse medical information, from imaging to clinical narratives. These medical modalities are often acquired in a many-to-many manner. However, current medical vision-language pretraining models…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Yuan Gao , Sangwook Kim , Jianzhong You , Chris McIntosh

Multimodality Representation Learning, as a technique of learning to embed information from different modalities and their correlations, has achieved remarkable success on a variety of applications, such as Visual Question Answering (VQA),…

Artificial Intelligence · Computer Science 2024-03-04 Muhammad Arslan Manzoor , Sarah Albarri , Ziting Xian , Zaiqiao Meng , Preslav Nakov , Shangsong Liang

Self-supervised pre-training techniques have achieved remarkable progress in Document AI. Most multimodal pre-trained models use a masked language modeling objective to learn bidirectional representations on the text modality, but they…

Computation and Language · Computer Science 2022-07-20 Yupan Huang , Tengchao Lv , Lei Cui , Yutong Lu , Furu Wei

Despite significant advancements in medical vision-language pre-training, existing methods have largely overlooked the inherent linguistic complexity and imbalanced isssue within medical reports, as well as the complex cross-modality…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Rongsheng Wang , Qingsong Yao , Zihang Jiang , Haoran Lai , Zhiyang He , Xiaodong Tao , S. Kevin Zhou

Large language models (LLMs) have demonstrated immense capabilities in understanding textual data and are increasingly being adopted to help researchers accelerate scientific discovery through knowledge extraction (information retrieval),…

Computer Vision and Pattern Recognition · Computer Science 2025-05-30 Robinson Umeike , Neil Getty , Fangfang Xia , Rick Stevens

The integration of artificial intelligence (AI) with radiology marks a transformative era in medicine. Vision foundation models have been adopted to enhance radiologic imaging analysis. However, the distinct complexities of radiologic 2D…

Computer Vision and Pattern Recognition · Computer Science 2025-05-30 Zhixiu Lu , Hailong Li , Nehal A. Parikh , Jonathan R. Dillman , Lili He

Precise spatial modeling in the operating room (OR) is foundational to many clinical tasks, supporting intraoperative awareness, hazard avoidance, and surgical decision-making. While existing approaches leverage large-scale multimodal…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Peiqi He , Zhenhao Zhang , Yixiang Zhang , Xiongjun Zhao , Shaoliang Peng

Contrastive Language-Image Pre-training (CLIP) has demonstrated outstanding performance in global image understanding and zero-shot transfer through large-scale text-image alignment. However, the core of medical image analysis often lies in…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Jiahui Peng , He Yao , Jingwen Li , Yanzhou Su , Sibo Ju , Yujie Lu , Jin Ye , Hongchun Lu , Xue Li , Lincheng Jiang , Min Zhu , Junlong Cheng

Vision-Language Pre-training (VLP) is drawing increasing interest for its ability to minimize manual annotation requirements while enhancing semantic understanding in downstream tasks. However, its reliance on image-text datasets poses…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Sinuo Wang , Yutong Xie , Yuyuan Liu , Qi Wu

Multimodal large language models (MLLMs) have gained significant attention due to their strong multimodal understanding capability. However, existing works rely heavily on modality-specific encoders, which usually differ in architecture and…

Computer Vision and Pattern Recognition · Computer Science 2025-01-10 Jiaming Han , Kaixiong Gong , Yiyuan Zhang , Jiaqi Wang , Kaipeng Zhang , Dahua Lin , Yu Qiao , Peng Gao , Xiangyu Yue

Vision-language models (VLMs) have made substantial progress across a wide range of visual question answering benchmarks, spanning visual reasoning, document understanding, and multimodal dialogue. These improvements are evident in a wide…

Computer Vision and Pattern Recognition · Computer Science 2026-02-23 Dhruba Ghosh , Yuhui Zhang , Ludwig Schmidt