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Heterogeneity is a fundamental characteristic of cancer. To accommodate heterogeneity, subgroup identification has been extensively studied and broadly categorized into unsupervised and supervised analysis. Compared to unsupervised…

Methodology · Statistics 2026-02-25 Xing Qin , Xu Liu , Shuangge Ma , Mengyun Wu

Multimodal machine learning integrating histopathology and molecular data shows promise for cancer prognostication. We systematically reviewed studies combining whole slide images (WSIs) and high-throughput omics to predict overall…

Quantitative Methods · Quantitative Biology 2025-07-30 Charlotte Jennings , Andrew Broad , Lucy Godson , Emily Clarke , David Westhead , Darren Treanor

Brain networks has attracted the interests of many neuroscientists. From functional MRI (fMRI) data, statistical tools have been developed to recover brain networks. However, the dimensionality of whole-brain fMRI, usually in hundreds of…

Methodology · Statistics 2014-04-08 Xi Luo

Biological systems are governed by structured molecular interactions, where pathways, regulatory circuits, and functional gene relationships shape cellular behavior and disease progression. Much of this knowledge is naturally represented as…

Machine Learning · Computer Science 2026-05-26 Yuwei Xue , Sakib Mostafa , James Zou , Joseph Liao , Maximilian Diehn , Ash A. Alizadeh , Lei Xing , Md. Tauhidul Islam

Whole Slide Images (WSIs) present a challenging computer vision task due to their gigapixel size and presence of numerous artefacts. Yet they are a valuable resource for patient diagnosis and stratification, often representing the gold…

Computer Vision and Pattern Recognition · Computer Science 2023-10-05 Amaya Gallagher-Syed , Luca Rossi , Felice Rivellese , Costantino Pitzalis , Myles Lewis , Michael Barnes , Gregory Slabaugh

In the realm of heterogeneous mixed autonomy, vehicles experience dynamic spatial correlations and nonlinear temporal interactions in a complex, non-Euclidean space. These complexities pose significant challenges to traditional…

Multiagent Systems · Computer Science 2024-08-19 Xin Gao , Zhaoyang Ma , Xueyuan Li , Xiaoqiang Meng , Zirui Li

Entity alignment typically suffers from the issues of structural heterogeneity and limited seed alignments. In this paper, we propose a novel Multi-channel Graph Neural Network model (MuGNN) to learn alignment-oriented knowledge graph (KG)…

Computation and Language · Computer Science 2019-08-28 Yixin Cao , Zhiyuan Liu , Chengjiang Li , Zhiyuan Liu , Juanzi Li , Tat-Seng Chua

Recently, knowledge graph (KG) augmented models have achieved noteworthy success on various commonsense reasoning tasks. However, KG edge (fact) sparsity and noisy edge extraction/generation often hinder models from obtaining useful…

Computation and Language · Computer Science 2021-06-07 Jun Yan , Mrigank Raman , Aaron Chan , Tianyu Zhang , Ryan Rossi , Handong Zhao , Sungchul Kim , Nedim Lipka , Xiang Ren

Squamous cell carcinoma (SCC) is the most common cancer subtype, with an increasing incidence and a significant impact on cancer-related mortality. SCC grading using whole slide images is inherently challenging due to the lack of a reliable…

On graph data, the multitude of node or edge types gives rise to heterogeneous information networks (HINs). To preserve the heterogeneous semantics on HINs, the rich node/edge types become a cornerstone of HIN representation learning.…

Machine Learning · Computer Science 2023-02-22 Trung-Kien Nguyen , Zemin Liu , Yuan Fang

Temporal Graph Neural Networks (TGNNs) have gained growing attention for modeling and predicting structures in temporal graphs. However, existing TGNNs primarily focus on pairwise interactions while overlooking higher-order structures that…

Machine Learning · Computer Science 2025-05-22 Jingzhe Liu , Zhigang Hua , Yan Xie , Bingheng Li , Harry Shomer , Yu Song , Kaveh Hassani , Jiliang Tang

Graph Neural Networks (GNNs) have become a prominent approach to machine learning with graphs and have been increasingly applied in a multitude of domains. Nevertheless, since most existing GNN models are based on flat message-passing…

Machine Learning · Computer Science 2022-10-27 Zhiqiang Zhong , Cheng-Te Li , Jun Pang

Heterogeneous molecular entities and their interactions, commonly depicted as a network, are crucial for advancing our systems-level understanding of biology. With recent advancements in high-throughput data generation and a significant…

Quantitative Methods · Quantitative Biology 2026-03-18 Kishan KC , Rui Li , Paribesh Regmi , Anne R. Haake

Domain generalization in computational histopathology is hindered by heterogeneity in whole slide images (WSIs), caused by variations in tissue preparation, staining, and imaging conditions across institutions. Unlike machine learning…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Hikmat Khan , Syed Farhan Alam Zaidi , Pir Masoom Shah , Kiruthika Balakrishnan , Rabia Khan , Muhammad Waqas , Jia Wu

Recent advancements in recommender systems have focused on integrating knowledge graphs (KGs) to leverage their auxiliary information. The core idea of KG-enhanced recommenders is to incorporate rich semantic information for more accurate…

Information Retrieval · Computer Science 2024-07-08 Darnbi Sakong , Viet Hung Vu , Thanh Trung Huynh , Phi Le Nguyen , Hongzhi Yin , Quoc Viet Hung Nguyen , Thanh Tam Nguyen

Graph neural networks (GNNs) based on message passing between neighboring nodes are known to be insufficient for capturing long-range interactions in graphs. In this project we study hierarchical message passing models that leverage a…

Machine Learning · Computer Science 2021-08-17 Ladislav Rampášek , Guy Wolf

Histopathology image analysis is the golden standard of clinical diagnosis for Cancers. In doctors daily routine and computer-aided diagnosis, the Whole Slide Image (WSI) of histopathology tissue is used for analysis. Because of the…

Computer Vision and Pattern Recognition · Computer Science 2023-11-23 Honglin Li , Yunlong Zhang , Chenglu Zhu , Jiatong Cai , Sunyi Zheng , Lin Yang

Isocitrate DeHydrogenase (IDH) mutation status is a crucial biomarker for glioma prognosis. However, current prediction methods are limited by the low availability and noise of functional MRI. Structural and morphological connectomes offer…

Computer Vision and Pattern Recognition · Computer Science 2025-08-14 Haotian Tang , Jianwei Chen , Xinrui Tang , Yunjia Wu , Zhengyang Miao , Chao Li

Recently, Vision Graph Neural Network (ViG) has gained considerable attention in computer vision. Despite its groundbreaking innovation, Vision Graph Neural Network encounters key issues including the quadratic computational complexity…

Computer Vision and Pattern Recognition · Computer Science 2025-03-20 Caoshuo Li , Tanzhe Li , Xiaobin Hu , Donghao Luo , Taisong Jin

Graph neural networks for heterogeneous graph embedding is to project nodes into a low-dimensional space by exploring the heterogeneity and semantics of the heterogeneous graph. However, on the one hand, most of existing heterogeneous graph…

Machine Learning · Computer Science 2022-12-01 Zezhi Shao , Yongjun Xu , Wei Wei , Fei Wang , Zhao Zhang , Feida Zhu