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The lack of interpretability in the field of medical image analysis has significant ethical and legal implications. Existing interpretable methods in this domain encounter several challenges, including dependency on specific models,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Lijie Hu , Songning Lai , Wenshuo Chen , Hongru Xiao , Hongbin Lin , Lu Yu , Jingfeng Zhang , Di Wang

Predicting the outcomes of prospective clinical trials remains a major challenge for large language models. Prior work has shown that both traditional correlational predictors, such as random forests and logistic regression, and strong…

Mechanistic interpretability aims to understand how neural networks generalize beyond their training data by reverse-engineering their internal structures. We introduce patterning as the dual problem: given a desired form of generalization,…

Machine Learning · Computer Science 2026-01-21 George Wang , Daniel Murfet

Classifying images with an interpretable decision-making process is a long-standing problem in computer vision. In recent years, Prototypical Part Networks has gained traction as an approach for self-explainable neural networks, due to…

Computer Vision and Pattern Recognition · Computer Science 2025-03-14 Zhijie Zhu , Lei Fan , Maurice Pagnucco , Yang Song

Deep neural networks for medical image classification often fail to generalize consistently in clinical practice due to violations of the i.i.d. assumption and opaque decision-making. This paper examines interpretability in deep neural…

Computer Vision and Pattern Recognition · Computer Science 2025-04-09 Mohammad Hossein Najafi , Mohammad Morsali , Mohammadreza Pashanejad , Saman Soleimani Roudi , Mohammad Norouzi , Saeed Bagheri Shouraki

As predictive machine learning models become increasingly adopted and advanced, their role has evolved from merely predicting outcomes to actively shaping them. This evolution has underscored the importance of Trustworthy AI, highlighting…

Machine Learning · Computer Science 2025-03-07 Fabio Michele Russo , Carlo Metta , Anna Monreale , Salvatore Rinzivillo , Fabio Pinelli

Black box models in machine learning have demonstrated excellent predictive performance in complex problems and high-dimensional settings. However, their lack of transparency and interpretability restrict the applicability of such models in…

Machine Learning · Computer Science 2020-06-09 Numair Sani , Jaron Lee , Razieh Nabi , Ilya Shpitser

The training of diffusion models is computationally intensive, making effective pre-training essential. However, real-world deployments often demand models of variable sizes due to diverse memory and computational constraints, posing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Yucheng Xie , Fu Feng , Ruixiao Shi , Jianlu Shen , Jing Wang , Yong Rui , Xin Geng

In recent years, Artificial Intelligence has become a powerful partner for complex tasks such as data analysis, prediction, and problem-solving, yet its lack of transparency raises concerns about its reliability. In sensitive domains such…

Machine Learning · Computer Science 2026-03-10 Jesús Sánchez Ochoa , Enrique Tomás Martínez Beltrán , Alberto Huertas Celdrán

A central challenge in neuroscience is understanding how neural system implements computation through its dynamics. We propose a nonlinear time series model aimed at characterizing interpretable dynamics from neural trajectories. Our model…

Quantitative Methods · Quantitative Biology 2016-10-28 Yuan Zhao , Il Memming Park

The problem of explaining deep learning models, and model predictions generally, has attracted intensive interest recently. Many successful approaches forgo global approximations in order to provide more faithful local interpretations of…

Machine Learning · Computer Science 2019-10-16 Isaac Ahern , Adam Noack , Luis Guzman-Nateras , Dejing Dou , Boyang Li , Jun Huan

Domain gaps arising from variations in imaging devices and population distributions pose significant challenges for machine learning in medical image analysis. Existing image-to-image translation methods primarily aim to learn mappings…

Computer Vision and Pattern Recognition · Computer Science 2026-01-08 Tianyang Zhang , Xinxing Cheng , Jun Cheng , Shaoming Zheng , He Zhao , Huazhu Fu , Alejandro F Frangi , Jiang Liu , Jinming Duan

Nowadays, deep neural networks are being used in many domains because of their high accuracy results. However, they are considered as "black box", means that they are not explainable for humans. On the other hand, in some tasks such as…

Machine Learning · Computer Science 2022-04-08 Niloofar Ranjbar , Reza Safabakhsh

Continual learning aims to update models under distribution shift without forgetting, yet many high-stakes deployments, such as healthcare, also require interpretability. In practice, models that adapt well (e.g., deep networks) are often…

Machine Learning · Computer Science 2026-04-21 Dongkyu Cho , Xiyue Li , Samrachana Adhikari , Rumi Chunara

Schizophrenia is a severe mental health condition that requires a long and complicated diagnostic process. However, early diagnosis is vital to control symptoms. Deep learning has recently become a popular way to analyse and interpret…

Machine Learning · Computer Science 2022-04-01 Daniel Organisciak , Hubert P. H. Shum , Ephraim Nwoye , Wai Lok Woo

Learning predictive models from high-dimensional sensory observations is fundamental for cyber-physical systems, yet the latent representations learned by standard world models lack physical interpretability. This limits their reliability,…

Machine Learning · Computer Science 2026-04-07 Zhenjiang Mao , Mrinall Eashaan Umasudhan , Ivan Ruchkin

Causal inference in longitudinal biomedical data remains a central challenge, especially in psychiatry, where symptom heterogeneity and latent confounding frequently undermine classical estimators. Most existing methods for treatment effect…

Machine Learning · Computer Science 2025-07-28 Eric V. Strobl

In science, we are interested not only in forecasting but also in understanding how predictions are made, specifically what the interpretable underlying model looks like. Data-driven machine learning technology can significantly streamline…

Symbolic Computation · Computer Science 2025-05-29 Weiting Liu , Jiaxu Cui , Jiao Hu , En Wang , Bo Yang

Most efforts in interpretability in deep learning have focused on (1) extracting explanations of a specific downstream task in relation to the input features and (2) imposing constraints on the model, often at the expense of predictive…

Machine Learning · Computer Science 2022-02-22 Marco Bertolini , Djork-Arné Clevert , Floriane Montanari

We provide a novel notion of what it means to be interpretable, looking past the usual association with human understanding. Our key insight is that interpretability is not an absolute concept and so we define it relative to a target model,…

Artificial Intelligence · Computer Science 2018-10-30 Amit Dhurandhar , Vijay Iyengar , Ronny Luss , Karthikeyan Shanmugam