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Whole slide pathology image classification presents challenges due to gigapixel image sizes and limited annotation labels, hindering model generalization. This paper introduces a prompt learning method to adapt large vision-language models…

Large Language Models (LLMs) have demonstrated remarkable success in tasks like the Winograd Schema Challenge (WSC), showcasing advanced textual common-sense reasoning. However, applying this reasoning to multimodal domains, where…

Modern recommender systems face critical challenges in handling information overload while addressing the inherent limitations of multimodal representation learning. Existing methods suffer from three fundamental limitations: (1) restricted…

Generative virtual staining (VS) models for high-throughput screening (HTS) can provide an estimated posterior distribution of possible biological feature values for each input and cell. However, when evaluating a VS model, the true…

The development of biologically interpretable and explainable models remains a key challenge in computational pathology, particularly for multistain immunohistochemistry (IHC) analysis. We present BioX-CPath, an explainable graph neural…

The appearance of histopathology images depends on tissue type, staining and digitization procedure. These vary from source to source and are the potential causes for domain-shift problems. Owing to this problem, despite the great success…

For invasive breast cancer, immunohistochemical (IHC) techniques are often used to detect the expression level of human epidermal growth factor receptor-2 (HER2) in breast tissue to formulate a precise treatment plan. From the perspective…

Immunohistochemistry (IHC) biomarkers are essential tools for reliable cancer diagnosis and subtyping. It requires cross-staining comparison among Whole Slide Images (WSIs) of IHCs and hematoxylin and eosin (H&E) slides. Currently,…

Visual In-Context Learning (VICL) has emerged as a powerful paradigm, enabling models to perform novel visual tasks by learning from in-context examples. The dominant "retrieve-then-prompt" approach typically relies on selecting the single…

Recent advancements in foundation models, such as the Segment Anything Model (SAM), have significantly impacted medical image segmentation, especially in retinal imaging, where precise segmentation is vital for diagnosis. Despite this…

We introduce a new AI-ready computational pathology dataset containing restained and co-registered digitized images from eight head-and-neck squamous cell carcinoma patients. Specifically, the same tumor sections were stained with the…

High-resolution (HR) image perception presents a key bottleneck for multimodal large language models (MLLMs). While visual search offers a promising solution, existing methods struggle with the trade-off between coverage and efficiency.…

The overexpression of the human epidermal growth factor receptor 2 (HER2) in breast cells is a key driver of HER2-positive breast cancer, a highly aggressive subtype requiring precise diagnosis and targeted therapy. Immunohistochemistry…

Modern supervised semantic segmentation methods are usually finetuned based on the supervised or self-supervised models pre-trained on ImageNet. Recent work shows that transferring the knowledge from CLIP to semantic segmentation via prompt…

Accurate cell counting in immunohistochemistry (IHC) images is critical for quantifying protein expression and aiding cancer diagnosis. However, the task remains challenging due to the chromogen overlap, variable biomarker staining, and…

As data requirements continue to grow, efficient learning increasingly depends on the curation and distillation of high-value data rather than brute-force scaling of model sizes. In the case of a hyperspectral image (HSI), the challenge is…

The diagnosis of cancer is mainly performed by visual analysis of the pathologists, through examining the morphology of the tissue slices and the spatial arrangement of the cells. If the microscopic image of a specimen is not stained, it…

Multiple instance learning (MIL) has emerged as a popular method for classifying histopathology whole slide images (WSIs). However, existing approaches typically rely on pre-trained models from large natural image datasets, such as…

While Vision-Language Models (VLMs) have achieved notable progress in computational pathology (CPath), the gigapixel scale and spatial heterogeneity of Whole Slide Images (WSIs) continue to pose challenges for multimodal understanding.…

In histopathology, tissue samples are often larger than a standard microscope slide, making stitching of multiple fragments necessary to process entire structures such as tumors. Automated stitching is a prerequisite for scaling analysis,…