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Over 1.4 billion chest X-rays (CXRs) are performed annually due to their cost-effectiveness as an initial diagnostic test. This scale of radiological studies provides a significant opportunity to streamline CXR interpretation and…

Existing X-ray based pre-trained vision models are usually conducted on a relatively small-scale dataset (less than 500k samples) with limited resolution (e.g., 224 $\times$ 224). However, the key to the success of self-supervised…

Image and Video Processing · Electrical Eng. & Systems 2024-04-30 Xiao Wang , Yuehang Li , Wentao Wu , Jiandong Jin , Yao Rong , Bo Jiang , Chuanfu Li , Jin Tang

Deep learning methods for chest X-ray interpretation typically rely on pretrained models developed for ImageNet. This paradigm assumes that better ImageNet architectures perform better on chest X-ray tasks and that ImageNet-pretrained…

Computer Vision and Pattern Recognition · Computer Science 2021-02-23 Alexander Ke , William Ellsworth , Oishi Banerjee , Andrew Y. Ng , Pranav Rajpurkar

Chest X-ray (CXR) is the most frequently ordered imaging test, supporting diverse clinical tasks from thoracic disease detection to postoperative monitoring. However, task-specific classification models are limited in scope, require costly…

Image and Video Processing · Electrical Eng. & Systems 2025-06-23 Zefan Yang , Xuanang Xu , Jiajin Zhang , Ge Wang , Mannudeep K. Kalra , Pingkun Yan

The scarcity of well-annotated diverse medical images is a major hurdle for developing reliable AI models in healthcare. Substantial technical advances have been made in generative foundation models for natural images. Here we develop…

Computer Vision and Pattern Recognition · Computer Science 2025-09-05 Yuanfeng Ji , Dan Lin , Xiyue Wang , Lu Zhang , Wenhui Zhou , Chongjian Ge , Ruihang Chu , Xiaoli Yang , Junhan Zhao , Junsong Chen , Xiangde Luo , Sen Yang , Jin Fang , Ping Luo , Ruijiang Li

Foundation models leveraging vision-language pretraining have shown promise in chest X-ray (CXR) interpretation, yet their real-world performance across diverse populations and diagnostic tasks remains insufficiently evaluated. This study…

Chest X-rays (CXRs) are a widely used imaging modality for the diagnosis and prognosis of lung disease. The image analysis tasks vary. Examples include pathology detection and lung segmentation. There is a large body of work where machine…

Image and Video Processing · Electrical Eng. & Systems 2023-05-19 Syed Muhammad Anwar , Abhijeet Parida , Sara Atito , Muhammad Awais , Gustavo Nino , Josef Kitler , Marius George Linguraru

Developing robust and versatile deep-learning models is essential for enhancing diagnostic accuracy and guiding clinical interventions in medical imaging, but it requires a large amount of annotated data. The advancement of deep learning…

Computer Vision and Pattern Recognition · Computer Science 2025-03-14 Nahid Ul Islam , DongAo Ma , Jiaxuan Pang , Shivasakthi Senthil Velan , Michael Gotway , Jianming Liang

Building generalizable medical AI systems requires pretraining strategies that are data-efficient and domain-aware. Unlike internet-scale corpora, clinical datasets such as MIMIC-CXR offer limited image counts and scarce annotations, but…

Recent advances in training deep learning models have demonstrated the potential to provide accurate chest X-ray interpretation and increase access to radiology expertise. However, poor generalization due to data distribution shifts in…

Image and Video Processing · Electrical Eng. & Systems 2021-02-23 Pranav Rajpurkar , Anirudh Joshi , Anuj Pareek , Andrew Y. Ng , Matthew P. Lungren

Machine learning has significantly advanced healthcare by aiding in disease prevention and treatment identification. However, accessing patient data can be challenging due to privacy concerns and strict regulations. Generating synthetic,…

Chest X-rays (CXRs) are among the most frequently performed imaging examinations worldwide, yet rising imaging volumes increase radiologist workload and the risk of diagnostic errors. Although artificial intelligence (AI) systems have shown…

X-ray imaging is a ubiquitous in radiology, yet most existing AI foundation models are limited to chest anatomy and fail to generalize across broader clinical tasks. In this work, we introduce XR-0, the multi-anatomy X-ray foundation model…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Nishank Singla , Krisztian Koos , Farzin Haddadpour , Amin Honarmandi Shandiz , Lovish Chum , Xiaojian Xu , Qing Jin , Erhan Bas

Recent foundation models have demonstrated strong performance in medical image representation learning, yet their comparative behaviour across datasets remains underexplored. This work benchmarks two large-scale chest X-ray (CXR) embedding…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Jiho Shin , Dominic Marshall , Matthieu Komorowski

The development of successful artificial intelligence models for chest X-ray analysis relies on large, diverse datasets with high-quality annotations. While several databases of chest X-ray images have been released, most include disease…

Image and Video Processing · Electrical Eng. & Systems 2024-05-21 Nicolás Gaggion , Candelaria Mosquera , Lucas Mansilla , Julia Mariel Saidman , Martina Aineseder , Diego H. Milone , Enzo Ferrante

Chest radiograph interpretation requires temporal reasoning over prior and current studies, yet most vision-language models are trained on static image-report pairs and lack explicit supervision for modeling longitudinal change. We…

The development of radiology foundation models (RFMs) is hindered by a reliance on brute-force scaling. Existing approaches often directly translate methods for natural images, which prioritize scale over precision and hence lead to brittle…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Yingtai Li , Shuai Ming , Mingyue Zhao , Haoran Lai , Rongsheng Wang , Rui Zhou , Rundong Wang , Yujia Li , Wei Wei , Shaohua Kevin Zhou

The image captioning task is increasingly prevalent in artificial intelligence applications for medicine. One important application is clinical report generation from chest radiographs. The clinical writing of unstructured reports is time…

Image and Video Processing · Electrical Eng. & Systems 2022-05-09 Edward Vendrow , Ethan Schonfeld

Pre-trained models, e.g., from ImageNet, have proven to be effective in boosting the performance of many downstream applications. It is too demanding to acquire large-scale annotations to build such models for medical imaging. Meanwhile,…

Computer Vision and Pattern Recognition · Computer Science 2021-03-31 Xiaosong Wang , Ziyue Xu , Leo Tam , Dong Yang , Daguang Xu

Despite the significant potential of Foundation Models (FMs) in medical imaging, their application to prognosis prediction remains challenging due to data scarcity, class imbalance, and task complexity, which limit their clinical adoption.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-16 Filippo Ruffini , Elena Mulero Ayllon , Linlin Shen , Paolo Soda , Valerio Guarrasi
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