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Related papers: Decomposing Physician Disagreement in HealthBench

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We introduce AcuityBench, a benchmark for evaluating whether language models identify the appropriate urgency of care from user medical presentations. Existing health benchmarks emphasize medical question answering, broad health…

The integration of artificial intelligence (AI) into medical diagnostic workflows requires robust and consistent evaluation methods to ensure reliability, clinical relevance, and the inherent variability in expert judgments. Traditional…

HealthBench, a benchmark designed to measure the capabilities of AI systems for health better (Arora et al., 2025), has advanced medical language model evaluation through physician-crafted dialogues and transparent rubrics. However, its…

Artificial Intelligence · Computer Science 2025-08-04 Fred Mutisya , Shikoh Gitau , Nasubo Ongoma , Keith Mbae , Elizabeth Wamicha

The deployment of Large Language Models (LLMs) in high-stakes clinical settings demands rigorous and reliable evaluation. However, existing medical benchmarks remain static, suffering from two critical limitations: (1) data contamination,…

Artificial Intelligence · Computer Science 2026-02-12 Zhiling Yan , Dingjie Song , Zhe Fang , Yisheng Ji , Xiang Li , Quanzheng Li , Lichao Sun

Bias in medical artificial intelligence is conventionally viewed as a defect requiring elimination. However, human reasoning inherently incorporates biases shaped by education, culture, and experience, suggesting their presence may be…

Artificial Intelligence · Computer Science 2026-03-05 Farhad Abtahi , Mehdi Astaraki , Fernando Seoane

Artificial intelligence (AI) systems accelerate medical workflows and improve diagnostic accuracy in healthcare, serving as second-opinion systems. However, the unpredictability of AI errors poses a significant challenge, particularly in…

Clinical dataset labels are rarely certain as annotators disagree and confidence is not uniform across cases. Typical aggregation procedures, such as majority voting, obscure this variability. In simple experiments on medical imaging…

Large language models are increasingly being assembled into medical multi-agent systems that emulate multidisciplinary consultation through specialist roles, peer review and consensus formation. In clinical decision support, however,…

Computation and Language · Computer Science 2026-05-28 Yinghao Zhu , Lei Gu , Zixiang Wang , Haoran Sang , Dehao Sui , Wen Tang , Lan Mi , Yasha Wang , Junyi Gao , Liang Yao , Tianfan Fu , Ewen Harrison , Lequan Yu , Liantao Ma

In medical imaging, inter-observer variability among radiologists often introduces label uncertainty, particularly in modalities where visual interpretation is subjective. Lung ultrasound (LUS) is a prime example-it frequently presents a…

Human-in-the-loop validation is essential in safety-critical clinical AI, yet the transition between initial model inference and expert correction is rarely analyzed as a structured signal. We introduce a diagnostic alignment framework in…

Artificial Intelligence · Computer Science 2026-02-27 Dimitrios P. Panagoulias , Evangelia-Aikaterini Tsichrintzi , Georgios Savvidis , Evridiki Tsoureli-Nikita

The deployment of Large Language Models in Medical Question Answering is severely hampered by ambiguous user queries, a significant safety risk that demonstrably reduces answer accuracy in high-stakes healthcare settings. In this paper, we…

Computation and Language · Computer Science 2026-01-27 Yaokun Liu , Yifan Liu , Phoebe Mbuvi , Zelin Li , Ruichen Yao , Gawon Lim , Dong Wang

Reference labels for machine-learning benchmarks are increasingly synthesized with LLM assistance, but their reliability remains underexamined. We audit MedCalc-Bench, a clinical benchmark for medical score computation whose labels were…

Artificial Intelligence · Computer Science 2026-04-14 Junze Ye , Daniel Tawfik , Alex J. Goodell , Nikhil V. Kotha , Mark K. Buyyounouski , Mohsen Bayati

Background: Clinical trials rely on transparent inclusion criteria to ensure generalizability. In contrast, benchmarks validating health-related large language models (LLMs) rarely characterize the "patient" or "query" populations they…

Artificial Intelligence · Computer Science 2026-04-17 Alvin Rajkomar , Pavan Sudarshan , Angela Lai , Lily Peng

Objective. Clinical AI documentation systems require evaluation methodologies that are clinically valid, economically viable, and sensitive to iterative changes. Methods requiring expert review per scoring instance are too slow and…

Artificial Intelligence · Computer Science 2026-04-28 Aaryan Shah , Andrew Hines , Alexia Downs , Denis Bajet , Paulius Mui , Fabiano Araujo , Laura Offutt , Aida Rutledge , Elizabeth Jimenez

The integration of artificial intelligence (AI), particularly Convolutional Neural Networks (CNNs), into dermatological diagnosis demonstrates substantial clinical potential. While existing literature predominantly benchmarks algorithmic…

Computer Vision and Pattern Recognition · Computer Science 2026-04-02 Loris Cino , Pier Luigi Mazzeo , Alessandro Martella , Giulia Radi , Renato Rossi , Cosimo Distante

For safety, medical AI systems undergo thorough evaluations before deployment, validating their predictions against a ground truth which is assumed to be fixed and certain. However, this ground truth is often curated in the form of…

LLM-as-a-Judge frameworks are increasingly trusted to automate evaluation in place of human experts, yet their reliability in high-stakes medical contexts remains unproven. We stress-test this assumption for detecting incomplete…

Computers and Society · Computer Science 2026-04-21 Alexandra DeLucia , Heyuan Huang , Sonal Joshi , Mahsa Yarmohammadi , Ahmed Hassoon , Mark Dredze

Medical images often contain multiple labels with imbalanced distributions and co-occurrence, leading to bias in multi-label medical image classification. Close collaboration between medical professionals and machine learning practitioners…

Human-Computer Interaction · Computer Science 2025-07-30 Shaohan Shi , Yuheng Shao , Haoran Jiang , Yunjie Yao , Zhijun Zhang , Xu Ding , Quan Li

Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex,…

Medical image segmentation is inherently uncertain. For a given image, there may be multiple plausible segmentation hypotheses, and physicians will often disagree on lesion and organ boundaries. To be suited to real-world application,…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 João Lourenço Silva , Arlindo L. Oliveira
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