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Multispecific antibodies offer transformative therapeutic potential by engaging multiple epitopes simultaneously, yet their efficacy is an emergent property governed by complex molecular architectures. Rational design is often bottlenecked…

In recent years, methods that combine contrastive learning with graph neural networks have emerged to address the challenges of recommendation systems, demonstrating powerful performance and playing a significant role in this domain.…

Information Retrieval · Computer Science 2025-09-08 Hao Chen , Wenming Ma , Zihao Chu , Mingqi Li

Disentangled generative models map a latent code vector to a target space, while enforcing that a subset of the learned latent codes are interpretable and associated with distinct properties of the target distribution. Recent advances have…

Machine Learning · Computer Science 2020-08-10 Zinan Lin , Kiran Koshy Thekumparampil , Giulia Fanti , Sewoong Oh

The selection of most informative and discriminative features from high-dimensional data has been noticed as an important topic in machine learning and data engineering. Using matrix factorization-based techniques such as nonnegative matrix…

Machine Learning · Computer Science 2022-10-04 Amir Moslemi , Arash Ahmadian

Background and objective: Employing deep learning models in critical domains such as medical imaging poses challenges associated with the limited availability of training data. We present a strategy for improving the performance and…

Computer Vision and Pattern Recognition · Computer Science 2024-03-27 Eva Pachetti , Sotirios A. Tsaftaris , Sara Colantonio

Unsupervised learning enables modeling complex images without the need for annotations. The representation learned by such models can facilitate any subsequent analysis of large image datasets. However, some generative factors that cause…

Image and Video Processing · Electrical Eng. & Systems 2020-08-27 Maxime W. Lafarge , Josien P. W. Pluim , Mitko Veta

Distributional shift between domains poses great challenges to modern machine learning algorithms. The domain generalization (DG) signifies a popular line targeting this issue, where these methods intend to uncover universal patterns across…

Computer Vision and Pattern Recognition · Computer Science 2023-10-05 Hao Chen , Qi Zhang , Zenan Huang , Haobo Wang , Junbo Zhao

Efficiently utilizing discriminative features is crucial for convolutional neural networks to achieve remarkable performance in medical image segmentation and is also important for model generalization across multiple domains, where letting…

Computer Vision and Pattern Recognition · Computer Science 2022-05-16 Ran Gu , Jiangshan Lu , Jingyang Zhang , Wenhui Lei , Xiaofan Zhang , Guotai Wang , Shaoting Zhang

Matrix completion is one of the key problems in signal processing and machine learning. In recent years, deep-learning-based models have achieved state-of-the-art results in matrix completion. Nevertheless, they suffer from two drawbacks:…

Machine Learning · Computer Science 2018-12-05 Duc Minh Nguyen , Evaggelia Tsiligianni , Nikos Deligiannis

Representations from large pretrained models such as BERT encode a range of features into monolithic vectors, affording strong predictive accuracy across a multitude of downstream tasks. In this paper we explore whether it is possible to…

Computation and Language · Computer Science 2021-09-14 Xiongyi Zhang , Jan-Willem van de Meent , Byron C. Wallace

Data mining and knowledge discovery are essential aspects of extracting valuable insights from vast datasets. Neural topic models (NTMs) have emerged as a valuable unsupervised tool in this field. However, the predominant objective in NTMs,…

Artificial Intelligence · Computer Science 2024-12-24 Xin Gao , Yang Lin , Ruiqing Li , Yasha Wang , Xu Chu , Xinyu Ma , Hailong Yu

In neutrino physics, analyses often depend on large simulated datasets, making it essential for models to generalise effectively to real-world detector data. Contrastive learning, a well-established technique in deep learning, offers a…

High Energy Physics - Experiment · Physics 2025-05-23 Alex Wilkinson , Radi Radev , Saul Alonso-Monsalve

Feature visualization is used to visualize learned features for black box machine learning models. Our approach explores an altered training process to improve interpretability of the visualizations. We argue that by using background…

Computer Vision and Pattern Recognition · Computer Science 2023-06-26 Ian E. Nielsen , Erik Grundeland , Joseph Snedeker , Ghulam Rasool , Ravi P. Ramachandran

The deep learning technique has been shown to be effectively addressed several image analysis tasks in the computer-aided diagnosis scheme for mammography. The training of an efficacious deep learning model requires large data with diverse…

Computer Vision and Pattern Recognition · Computer Science 2023-09-08 Zheren Li , Zhiming Cui , Lichi Zhang , Sheng Wang , Chenjin Lei , Xi Ouyang , Dongdong Chen , Xiangyu Zhao , Yajia Gu , Zaiyi Liu , Chunling Liu , Dinggang Shen , Jie-Zhi Cheng

Identifying altered pathways that are associated with specific cancer types can potentially bring a significant impact on cancer patient treatment. Accurate identification of such key altered pathways information can be used to develop…

Machine Learning · Statistics 2017-12-05 Sunho Park , Tae Hyun Hwang

The ability to learn disentangled representations that split underlying sources of variation in high dimensional, unstructured data is important for data efficient and robust use of neural networks. While various approaches aiming towards…

Machine Learning · Statistics 2019-05-15 Raphael Suter , Đorđe Miladinović , Bernhard Schölkopf , Stefan Bauer

We introduce a new method based on nonnegative matrix factorization, Neural NMF, for detecting latent hierarchical structure in data. Datasets with hierarchical structure arise in a wide variety of fields, such as document classification,…

Machine Learning · Computer Science 2023-03-02 Tyler Will , Runyu Zhang , Eli Sadovnik , Mengdi Gao , Joshua Vendrow , Jamie Haddock , Denali Molitor , Deanna Needell

Nonnegative matrix factorization (NMF) is a popular method used to reduce dimensionality in data sets whose elements are nonnegative. It does so by decomposing the data set of interest, $\mathbf{X}$, into two lower rank nonnegative matrices…

Methodology · Statistics 2021-07-05 Phillip Shreeves , Jeffrey L. Andrews , Xinchen Deng , Ramie Ali-Adeeb , Andrew Jirasek

Modeling various aspects that make a music piece unique is a challenging task, requiring the combination of multiple sources of information. Deep learning is commonly used to obtain representations using various sources of information, such…

Sound · Computer Science 2021-04-05 Andres Ferraro , Xavier Favory , Konstantinos Drossos , Yuntae Kim , Dmitry Bogdanov

Many unsupervised hashing methods are implicitly established on the idea of reconstructing the input data, which basically encourages the hashing codes to retain as much information of original data as possible. However, this requirement…

Computer Vision and Pattern Recognition · Computer Science 2021-05-20 Zexuan Qiu , Qinliang Su , Zijing Ou , Jianxing Yu , Changyou Chen