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Pathology foundation models (PFMs) have emerged as a core approach for learning transferable representations from whole slide images (WSIs), and they are typically benchmarked through downstream clinical endpoints. While such task level…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Bokai Zhao , Yiyang Zhang , Yuanchi Zhu , Hanqing Chao , Long Bai , Tai Ma , Minfeng Xu , Ming Song , Tianzi Jiang

Processing giga-pixel whole slide histopathology images (WSI) is a computationally expensive task. Multiple instance learning (MIL) has become the conventional approach to process WSIs, in which these images are split into smaller patches…

Computer Vision and Pattern Recognition · Computer Science 2023-07-06 Ramin Nakhli , Puria Azadi Moghadam , Haoyang Mi , Hossein Farahani , Alexander Baras , Blake Gilks , Ali Bashashati

The emergence of foundation models in computational pathology has transformed histopathological image analysis, with whole slide imaging (WSI) diagnosis being a core application. Traditionally, weakly supervised fine-tuning via multiple…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Jiawen Li , Jiali Hu , Qiehe Sun , Renao Yan , Minxi Ouyang , Tian Guan , Anjia Han , Chao He , Yonghong He

Developing self-supervised learning (SSL) models that can learn universal and transferable representations of H&E gigapixel whole-slide images (WSIs) is becoming increasingly valuable in computational pathology. These models hold the…

Image and Video Processing · Electrical Eng. & Systems 2024-08-07 Guillaume Jaume , Anurag Vaidya , Andrew Zhang , Andrew H. Song , Richard J. Chen , Sharifa Sahai , Dandan Mo , Emilio Madrigal , Long Phi Le , Faisal Mahmood

In the field of computational pathology, the use of decision support systems powered by state-of-the-art deep learning solutions has been hampered by the lack of large labeled datasets. Until recently, studies relied on datasets in the…

Computer Vision and Pattern Recognition · Computer Science 2018-10-01 Gabriele Campanella , Vitor Werneck Krauss Silva , Thomas J. Fuchs

Vision-language foundation models such as CLIP have achieved tremendous results in global vision-language alignment, but still show some limitations in creating representations for specific image regions. % To address this problem, we…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Walid Bousselham , Sofian Chaybouti , Christian Rupprecht , Vittorio Ferrari , Hilde Kuehne

Remarkable strides in computational pathology have been made in the task-agnostic foundation model that advances the performance of a wide array of downstream clinical tasks. Despite the promising performance, there are still several…

Tumor segmentation plays a critical role in histopathology, but it requires costly, fine-grained image-mask pairs annotated by pathologists. Thus, synthesizing histopathology data to expand the dataset is highly desirable. Previous works…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Hong Liu , Haosen Yang , Evi M. C. Huijben , Mark Schuiveling , Ruisheng Su , Josien P. W. Pluim , Mitko Veta

Digital whole-slide images of pathological tissue samples have recently become feasible for use within routine diagnostic practice. These gigapixel sized images enable pathologists to perform reviews using computer workstations instead of…

Human-Computer Interaction · Computer Science 2016-10-14 Jesper Molin , Anna Bodén , Darren Treanor , Morten Fjeld , Claes Lundström

Histopathologists establish cancer grade by assessing histological structures, such as glands in prostate cancer. Yet, digital pathology pipelines often rely on grid-based tiling that ignores tissue architecture. This introduces irrelevant…

The recent surge in performance for image analysis of digitised pathology slides can largely be attributed to the advances in deep learning. Deep models can be used to initially localise various structures in the tissue and hence facilitate…

Image and Video Processing · Electrical Eng. & Systems 2022-11-15 Simon Graham , Quoc Dang Vu , Mostafa Jahanifar , Shan E Ahmed Raza , Fayyaz Minhas , David Snead , Nasir Rajpoot

Foundation models have emerged as a powerful paradigm in computational pathology (CPath), enabling scalable and generalizable analysis of histopathological images. While early developments centered on uni-modal models trained solely on…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Dong Li , Guihong Wan , Xintao Wu , Xinyu Wu , Xiaohui Chen , Yi He , Christine G. Lian , Peter K. Sorger , Yevgeniy R. Semenov , Chen Zhao

In crisis management and remote sensing, image segmentation plays a crucial role, enabling tasks like disaster response and emergency planning by analyzing visual data. Neural networks are able to analyze satellite acquisitions and…

Computer Vision and Pattern Recognition · Computer Science 2025-05-06 Daniele Rege Cambrin , Luca Colomba , Paolo Garza

The emergence of digital pathology has opened new horizons for histopathology and cytology. Artificial-intelligence algorithms are able to operate on digitized slides to assist pathologists with diagnostic tasks. Whereas machine learning…

In the field of deep learning, large architectures often obtain the best performance for many tasks, but also require massive datasets. In the histological domain, tissue images are expensive to obtain and constitute sensitive medical…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Andrei-Alexandru Preda , Iulian-Marius Tăiatu , Dumitru-Clementin Cercel

Representation learning of pathology whole-slide images (WSIs) has primarily relied on weak supervision with Multiple Instance Learning (MIL). This approach leads to slide representations highly tailored to a specific clinical task.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Tim Lenz , Peter Neidlinger , Marta Ligero , Georg Wölflein , Marko van Treeck , Jakob Nikolas Kather

To handle the large scale of whole slide images in computational pathology, most approaches first tessellate the images into smaller patches, extract features from these patches, and finally aggregate the feature vectors with…

Computer Vision and Pattern Recognition · Computer Science 2025-03-05 Benedikt Roth , Valentin Koch , Sophia J. Wagner , Julia A. Schnabel , Carsten Marr , Tingying Peng

Whole slide imaging is fundamental to biomedical microscopy and computational pathology. Previously, learning representations for gigapixel-sized whole slide images (WSIs) has relied on multiple instance learning with weak labels, which do…

Computer Vision and Pattern Recognition · Computer Science 2024-05-27 Xinhai Hou , Cheng Jiang , Akhil Kondepudi , Yiwei Lyu , Asadur Chowdury , Honglak Lee , Todd C. Hollon

A crucial step to efficiently integrate Whole Slide Images (WSIs) in computational pathology is assigning a single high-quality feature vector, i.e., one embedding, to each WSI. With the existence of many pre-trained deep neural networks…

Image and Video Processing · Electrical Eng. & Systems 2025-05-22 Sobhan Hemati , Ghazal Alabtah , Saghir Alfasly , H. R. Tizhoosh

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Wei-Wen Hsu , Yongfang Wu , Chang Hao , Yu-Ling Hou , Xiang Gao , Yun Shao , Xueli Zhang , Tao He , Yanhong Tai
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