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Today's quantum computers are comprised of tens of qubits interacting with each other and the environment in increasingly complex networks. In order to achieve the best possible performance when operating such systems, it is necessary to…

Quantum Physics · Physics 2021-12-08 J. H. Béjanin , C. T. Earnest , Y. R. Sanders , M. Mariantoni

In this note, we describe an experiment on portfolio optimization using the Quadratic Unconstrained Binary Optimization (QUBO) formulation. The dataset we use is taken from a real-world problem for which a classical solution is currently…

Quantum algorithms are getting extremely popular due to their potential to significantly outperform classical algorithms. Yet, applying quantum algorithms to optimization problems meets challenges related to the efficiency of quantum…

Quantum data encoding (QDE) enables faster com-putations than classical algorithms through superposition and en-tanglement. Circuit cutting and knitting are effective techniques for ameliorating current noisy quantum processing unit (QPUs)…

Quantum Physics · Physics 2025-11-19 Ziqing Guo , Jan Balewski , Kewen Xiao , Ziwen Pan

Co-optimizing mRNA sequences for both codon optimality and secondary structure is crucial for producing stable and efficacious mRNA therapeutics. Codon optimization, which adjusts nucleotide sequences to enhance translational efficiency,…

Computed tomography (CT) is an important imaging technique used in medical analysis of the internal structure of the human body. Previously, image segmentation methods were required after acquiring reconstructed CT images to obtain…

Quantum Physics · Physics 2024-09-17 Kyungtaek Jun

Low-bit floating-point (FP) formats, such as FP8, provide significant acceleration and memory savings in model training thanks to native hardware support on modern GPUs and NPUs. However, we analyze that FP8 quantization offers speedup…

Machine Learning · Computer Science 2025-10-29 Kanghyun Choi , Hyeyoon Lee , SunJong Park , Dain Kwon , Jinho Lee

In this paper, we propose a quantum algorithm that supports a real-valued higher-order unconstrained binary optimization (HUBO) problem. This algorithm is based on the Grover adaptive search that originally supported HUBO with integer…

Signal Processing · Electrical Eng. & Systems 2023-02-17 Masaya Norimoto , Ryuhei Mori , Naoki Ishikawa

Quantum Selected Configuration Interaction (QSCI) and an extended protocol known as Sample-based Quantum Diagonalization (SQD) have emerged as promising algorithms to solve the electronic Schr\"odinger equation with noisy quantum computers.…

Quantum Physics · Physics 2025-08-26 Don Danilov , Javier Robledo-Moreno , Kevin J. Sung , Mario Motta , James Shee

A fundamental challenge in photonics-based deterministic quantum information processing is to realize key transformations on time scales shorter than those of detrimental decoherence and loss mechanisms. This challenge has been addressed…

Quantum Physics · Physics 2026-02-12 Emil Grovn , Matias Bundgaard-Nielsen , Jesper Mørk , Dirk Englund , Mikkel Heuck

In just the last decade, a multitude of bio-technologies and software pipelines have emerged to revolutionize genomics. To further their central goal, they aim to accelerate and improve the quality of de novo whole-genome assembly starting…

Genomics · Quantitative Biology 2015-06-11 Francesco Vezzi , Giuseppe Narzisi , Bud Mishra

The problem of selecting an appropriate number of features in supervised learning problems is investigated in this paper. Starting with common methods in machine learning, we treat the feature selection task as a quadratic unconstrained…

Quantum Physics · Physics 2023-06-21 Gerhard Hellstern , Vanessa Dehn , Martin Zaefferer

As quantum computing technology advances, the complexity of quantum algorithms increases, necessitating a shift from low-level circuit descriptions to high-level programming paradigms. This paper addresses the challenges of developing a…

Quantum Physics · Physics 2025-03-04 Israel Reichental , Ravid Alon , Lior Preminger , Matan Vax , Amir Naveh

In more recent years, there has been increasing research interest in exploiting the use of application specific hardware for solving optimisation problems. Examples of solvers that use specialised hardware are IBM's Quantum System One and…

Neural and Evolutionary Computing · Computer Science 2022-11-14 Mayowa Ayodele

This work presents a novel tensor network algorithm for solving Quadratic Unconstrained Binary Optimization (QUBO) problems, Quadratic Unconstrained Discrete Optimization (QUDO) problems, and Tensor Quadratic Unconstrained Discrete…

Recent works on quantum algorithms for solving semidefinite optimization (SDO) problems have leveraged a quantum-mechanical interpretation of positive semidefinite matrices to develop methods that obtain quantum speedups with respect to the…

Quantum Physics · Physics 2025-06-06 Brandon Augustino , Giacomo Nannicini , Tamás Terlaky , Luis Zuluaga

We experimentally demonstrate that the bias-field digitized counterdiabatic quantum optimization (BF-DCQO) algorithm, implemented on IonQ's fully connected trapped-ion quantum processors, offers an efficient approach to solving dense…

In this study, we explore how quantum pathfinding algorithm called Gaussian Amplitude Amplification (GAA) can be used to solve the DNA sequencing problem. To do this, sequencing by hybridization was assumed wherein short fragments of the…

Mesoscale and Nanoscale Physics · Physics 2023-11-01 Richard Marin , Carlos Baldo

Modular quantum computing architectures are a promising alternative to monolithic QPU (Quantum Processing Unit) designs for scaling up quantum devices. They refer to a set of interconnected QPUs or cores consisting of tightly coupled…

Feedback-based methods have gained significant attention as an alternative training paradigm for the Quantum Approximate Optimization Algorithm (QAOA) in solving combinatorial optimization problems such as MAX-CUT. In particular, Quantum…

Quantum Physics · Physics 2026-02-16 Masih Mozakka , Mohsen Heidari