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We explicitly define the notions of (bona fide, approximate or asymptotic) compound p-values and e-values, which have been implicitly presented and used in the recent multiple testing literature. While it is known that the e-BH procedure…

Methodology · Statistics 2025-07-24 Nikolaos Ignatiadis , Ruodu Wang , Aaditya Ramdas

Transitioning from Phase 2 to Phase 3 in drug development, at a rate of $\approx$40%, is the most stringent among phase transitions (Hay et al. (2014)). Yet, success rate at Phase 3 leading to approval is only $\approx$50% (Arrowsmith…

Methodology · Statistics 2025-10-29 Yujia Sun , Yang Han , Xingya Wang , Szu-Yu Tang , Yushi Liu , Jason C. Hsu

The paper introduces a novel conditional independence (CI) based method for linear and nonlinear, lagged and contemporaneous causal discovery from observational time series in the causally sufficient case. Existing CI-based methods such as…

Methodology · Statistics 2022-01-07 Jakob Runge

While Conformal Prediction (CP) has proven to be a powerful framework for uncertainty quantification, guaranteeing conditional coverage remains a central challenge. Although finite-sample, distribution-free conditional validity is known to…

Methodology · Statistics 2026-05-27 Félix Laplante

An important aspect of the performance of algorithms that predict individualized treatment effects (ITE) is moderate calibration, i.e., the average treatment effect among individuals with predicted treatment effect of z being equal to z.…

Methodology · Statistics 2025-12-10 Mohsen Sadatsafavi , Jeroen Hoogland , Thomas P. A. Debray , John Petkau

The validity of instrumental variable (IV) designs is typically tested using two types of falsification tests. We characterize these tests as conditional independence tests between negative control variables -- proxies for unobserved…

Econometrics · Economics 2025-04-29 Oren Danieli , Daniel Nevo , Itai Walk , Bar Weinstein , Dan Zeltzer

We propose the Variation Calibration Error (VCE) metric for assessing the calibration of machine learning classifiers. The metric can be viewed as an extension of the well-known Expected Calibration Error (ECE) which assesses the…

Machine Learning · Computer Science 2026-02-16 Andrew Thompson , Vivek Desai

Handling missing data is a central challenge in data-driven analysis. Modern imputation methods not only aim for accurate reconstruction but also differ in how they represent and quantify uncertainty. Yet, the reliability and calibration of…

Databases · Computer Science 2025-11-27 Zarin Tahia Hossain , Mostafa Milani

Combinatorial interaction testing (CIT) is a well-known technique, but the industrial experience is needed to determine its effectiveness in different application domains. We present a case study introducing a unified framework for…

Software Engineering · Computer Science 2019-03-14 Bestoun S. Ahmed , Amador Pahim , Cleber R. Rosa Junior , D. Richard Kuhn , Miroslav Bures

Both genetic drift and natural selection cause the frequencies of alleles in a population to vary over time. Discriminating between these two evolutionary forces, based on a time series of samples from a population, remains an outstanding…

Populations and Evolution · Quantitative Biology 2013-12-09 Alison Feder , Sergey Kryazhimskiy , Joshua B. Plotkin

Language model outputs are not always reliable, thus prompting research into how to adapt model responses based on uncertainty. Common approaches include: \emph{abstention}, where models refrain from generating responses when uncertain; and…

Computation and Language · Computer Science 2025-08-13 Zhengping Jiang , Anqi Liu , Benjamin Van Durme

Chain-of-thought (CoT) reasoning with self-consistency improves performance by aggregating multiple sampled reasoning paths. In this setting, correctness is no longer tied to a single reasoning trace but to the aggregation rule over a pool…

Machine Learning · Statistics 2026-05-15 Yu Gu , Zijun Yu , Vahid Partovi Nia , Masoud Asgharian

Handling model mismatch is a common challenge in model predictive control (MPC). While robust MPC is effective, its conservatism often makes it less desirable. Certainty-equivalence MPC (CE-MPC), which uses a nominal model, offers an…

Optimization and Control · Mathematics 2026-02-10 Changrui Liu , Shengling Shi , Bart De Schutter

Instruction tuning enhances the instruction following ability of large language models by finetuning with supervised instruction data. Previous work proposes in-context instruction tuning (ICIT) where specific positive or negative examples…

Computation and Language · Computer Science 2024-06-05 Tianci Xue , Ziqi Wang , Yixia Li , Yun Chen , Guanhua Chen

This paper shows that conditional independence reasoning can be applied to optimize epistemic model checking, in which one verifies that a model for a number of agents operating with imperfect information satisfies a formula expressed in a…

Logic in Computer Science · Computer Science 2017-07-28 Ron van der Meyden

This paper proposes new specification tests for conditional models with discrete responses, which are key to apply efficient maximum likelihood methods, to obtain consistent estimates of partial effects and to get appropriate predictions of…

Statistics Theory · Mathematics 2018-02-01 Igor Kheifets , Carlos Velasco

There are a number of ways to test for the absence/presence of a spatial signal in a completely observed fine-resolution image. One of these is a powerful nonparametric procedure called Enhanced False Discovery Rate (EFDR). A drawback of…

Methodology · Statistics 2020-10-20 Hsin-Cheng Huang , Noel Cressie , Andrew Zammit-Mangion , Guowen Huang

We study hybrid control trials (HCTs), in which a randomized controlled trial (RCT) is augmented with external control patients. Existing approaches for HCTs typically assume conditional exchangeability of the concurrent and external…

Methodology · Statistics 2025-11-21 Alissa Gordon , Emilie Højbjerre-Frandsen , Alejandro Schuler

We propose an adaptive sampling approach for multiple testing which aims to maximize statistical power while ensuring anytime false discovery control. We consider $n$ distributions whose means are partitioned by whether they are below or…

Machine Learning · Statistics 2019-07-18 Kevin Jamieson , Lalit Jain

Most existing imitation learning approaches assume the demonstrations are drawn from experts who are optimal, but relaxing this assumption enables us to use a wider range of data. Standard imitation learning may learn a suboptimal policy…

Machine Learning · Computer Science 2022-01-27 Songyuan Zhang , Zhangjie Cao , Dorsa Sadigh , Yanan Sui