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Recent progress in image generation has sparked research into controlling these models through condition signals, with various methods addressing specific challenges in conditional generation. Instead of proposing another specialized…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Xirui Li , Charles Herrmann , Kelvin C. K. Chan , Yinxiao Li , Deqing Sun , Chao Ma , Ming-Hsuan Yang

Diffusion models are a class of generative models that learn to synthesize samples by inverting a diffusion process that gradually maps data into noise. While these models have enjoyed great success recently, a full theoretical…

Machine Learning · Computer Science 2023-09-22 Raja Marjieh , Ilia Sucholutsky , Thomas A. Langlois , Nori Jacoby , Thomas L. Griffiths

Diffusion model-based approaches have shown promise in data-driven planning, but there are no safety guarantees, thus making it hard to be applied for safety-critical applications. To address these challenges, we propose a new method,…

Machine Learning · Computer Science 2023-06-02 Wei Xiao , Tsun-Hsuan Wang , Chuang Gan , Daniela Rus

Simulation is critical for safety evaluation in autonomous driving, particularly in capturing complex interactive behaviors. However, generating realistic and controllable traffic scenarios in long-tail situations remains a significant…

Artificial Intelligence · Computer Science 2025-05-28 Haohong Lin , Xin Huang , Tung Phan-Minh , David S. Hayden , Huan Zhang , Ding Zhao , Siddhartha Srinivasa , Eric M. Wolff , Hongge Chen

Nuclei segmentation and classification is a significant process in pathology image analysis. Deep learning-based approaches have greatly contributed to the higher accuracy of this task. However, those approaches suffer from the imbalanced…

Computer Vision and Pattern Recognition · Computer Science 2023-06-27 Hyun-Jic Oh , Won-Ki Jeong

Diffusion models have led to the revolutionizing of generative modeling in numerous image synthesis tasks. Nevertheless, it is not trivial to directly apply diffusion models for synthesizing an image of a target person wearing a given…

Computer Vision and Pattern Recognition · Computer Science 2024-09-13 Siqi Wan , Yehao Li , Jingwen Chen , Yingwei Pan , Ting Yao , Yang Cao , Tao Mei

Diffusion models are a class of probabilistic generative models that have been widely used as a prior for image processing tasks like text conditional generation and inpainting. We demonstrate that these models can be adapted to make…

Machine Learning · Computer Science 2023-06-14 Marc Finzi , Anudhyan Boral , Andrew Gordon Wilson , Fei Sha , Leonardo Zepeda-Núñez

Given the audio-visual clip of the speaker, facial reaction generation aims to predict the listener's facial reactions. The challenge lies in capturing the relevance between video and audio while balancing appropriateness, realism, and…

Computer Vision and Pattern Recognition · Computer Science 2025-06-05 Jiaming Li , Sheng Wang , Xin Wang , Yitao Zhu , Honglin Xiong , Zixu Zhuang , Qian Wang

Most 3D generation research focuses on up-projecting 2D foundation models into the 3D space, either by minimizing 2D Score Distillation Sampling (SDS) loss or fine-tuning on multi-view datasets. Without explicit 3D priors, these methods…

Computer Vision and Pattern Recognition · Computer Science 2023-12-11 Lihe Ding , Shaocong Dong , Zhanpeng Huang , Zibin Wang , Yiyuan Zhang , Kaixiong Gong , Dan Xu , Tianfan Xue

Accurate prediction of human or vehicle trajectories with good diversity that captures their stochastic nature is an essential task for many applications. However, many trajectory prediction models produce unreasonable trajectory samples…

Computer Vision and Pattern Recognition · Computer Science 2025-02-10 Qingze , Liu , Danrui Li , Samuel S. Sohn , Sejong Yoon , Mubbasir Kapadia , Vladimir Pavlovic

When reliable target structures are unavailable at scale or phenotypes arise from dysregulated pathways, transcriptomic perturbations provide a system-level functional readout for drug action. In this work, we formalize…

Machine Learning · Computer Science 2026-05-18 Ziyu Xu , Zijian Zhang , Liang Wang , Zhiyuan Liu , Qiang Liu , Shu Wu , Liang Wang

Diffusion models, a family of generative models based on deep learning, have become increasingly prominent in cutting-edge machine learning research. With a distinguished performance in generating samples that resemble the observed data,…

Machine Learning · Computer Science 2023-05-02 Lequan Lin , Zhengkun Li , Ruikun Li , Xuliang Li , Junbin Gao

Since its foundations, more than one hundred years ago, the field of structural biology has strived to understand and analyze the properties of molecules and their interactions by studying the structure that they take in 3D space. However,…

Biomolecules · Quantitative Biology 2023-02-27 Gabriele Corso

Diffusion models have emerged as powerful generative models for graph generation, yet their use for conditional graph generation remains a fundamental challenge. In particular, guiding diffusion models on graphs under arbitrary reward…

Machine Learning · Computer Science 2025-05-27 Victor M. Tenorio , Nicolas Zilberstein , Santiago Segarra , Antonio G. Marques

Prototype-based meta-learning has emerged as a powerful technique for addressing few-shot learning challenges. However, estimating a deterministic prototype using a simple average function from a limited number of examples remains a fragile…

Machine Learning · Computer Science 2023-11-08 Yingjun Du , Zehao Xiao , Shengcai Liao , Cees Snoek

Data-driven dynamic models of cell biology can be used to predict cell response to unseen perturbations. Recent work (CellBox) had demonstrated the derivation of interpretable models with explicit interaction terms, in which the parameters…

Molecular Networks · Quantitative Biology 2021-04-15 Weiqi Ji , Bo Yuan , Ciyue Shen , Aviv Regev , Chris Sander , Sili Deng

In this work, we propose a novel framework to enable diffusion models to adapt their generation quality based on real-time network bandwidth constraints. Traditional diffusion models produce high-fidelity images by performing a fixed number…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Xi Zhang , Hanwei Zhu , Yan Zhong , Jiamang Wang , Weisi Lin

Diffusion models (DMs) embark a new era of generative modeling and offer more opportunities for efficient generating high-quality and realistic data samples. However, their widespread use has also brought forth new challenges in model…

Computer Vision and Pattern Recognition · Computer Science 2024-10-14 Jingyao Xu , Yuetong Lu , Yandong Li , Siyang Lu , Dongdong Wang , Xiang Wei

Predicting the binding structure of a small molecule ligand to a protein -- a task known as molecular docking -- is critical to drug design. Recent deep learning methods that treat docking as a regression problem have decreased runtime…

Biomolecules · Quantitative Biology 2023-02-14 Gabriele Corso , Hannes Stärk , Bowen Jing , Regina Barzilay , Tommi Jaakkola

Discrete diffusion models generate sequences by iteratively denoising samples corrupted by categorical noise, offering an appealing alternative to autoregressive decoding for structured and symbolic generation. However, standard training…

Machine Learning · Computer Science 2026-02-04 Huu Binh Ta , Michael Cardei , Alvaro Velasquez , Ferdinando Fioretto
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