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Meta-analysis, by synthesizing effect estimates from multiple studies conducted in diverse settings, stands at the top of the evidence hierarchy in clinical research. Yet, conventional approaches based on fixed- or random-effects models…

Estimation of causal effects involves crucial assumptions about the data-generating process, such as directionality of effect, presence of instrumental variables or mediators, and whether all relevant confounders are observed. Violation of…

Machine Learning · Computer Science 2021-09-01 Amit Sharma , Vasilis Syrgkanis , Cheng Zhang , Emre Kıcıman

Systematic reviews are essential for evidence-based medicine, but reviewing 1.5 million+ annual publications manually is infeasible. Current AI approaches suffer from hallucinations in systematic review tasks, with studies reporting rates…

Artificial Intelligence · Computer Science 2026-01-07 Duc Ngo , Arya Rahgoza

In addition to efficient statistical estimators of a treatment's effect, successful application of causal inference requires specifying assumptions about the mechanisms underlying observed data and testing whether they are valid, and to…

Methodology · Statistics 2020-11-10 Amit Sharma , Emre Kiciman

We explore the hyperparameters and introduce a methodological framework to convert disease patterns from time series data of blood test results into correlation graphs for causal hypothesis exploration. The networks represent hypotheses…

Other Quantitative Biology · Quantitative Biology 2025-12-29 David Patrick Duys Montealegre , Alexander Fulton , Mahta Haghighat Ghahfarokhi , Abicumaran Uthamacumaran , Hector Zenil

Causal graphs are commonly used to understand and model complex systems. Researchers often construct these graphs from different perspectives, leading to significant variations for the same problem. Comparing causal graphs is, therefore,…

Machine Learning · Computer Science 2025-03-17 Ning-Yuan Georgia Liu , Flower Yang , Mohammad S. Jalali

Epidemiological evidence is based on multiple data sources including clinical trials, cohort studies, surveys, registries and expert opinions. Merging information from different sources opens up new possibilities for the estimation of…

Applications · Statistics 2024-07-03 Juha Karvanen , Santtu Tikka , Antti Hyttinen

We study compiled AI, a paradigm in which large language models generate executable code artifacts during a compilation phase, after which workflows execute deterministically without further model invocation. This paradigm has antecedents…

Learning-based signal processing systems increasingly support high-stakes medical decisions using heterogeneous biomedical signals, including medical images, physiological time series, and clinical records. Despite strong predictive…

Signal Processing · Electrical Eng. & Systems 2026-03-02 Surajit Das , Maxine Tan

Knowing the effect of an intervention is critical for human decision-making, but current approaches for causal effect estimation rely on manual data collection and structuring, regardless of the causal assumptions. This increases both the…

Machine Learning · Computer Science 2024-10-29 Nikita Dhawan , Leonardo Cotta , Karen Ullrich , Rahul G. Krishnan , Chris J. Maddison

Objective: Causality mining is an active research area, which requires the application of state-of-the-art natural language processing techniques. In the healthcare domain, medical experts create clinical text to overcome the limitation of…

Drawing causal conclusions from observational data requires making assumptions about the true data-generating process. Causal inference research typically considers low-dimensional data, such as categorical or numerical fields in structured…

Computation and Language · Computer Science 2021-02-11 Zach Wood-Doughty , Ilya Shpitser , Mark Dredze

The do-calculus was developed in 1995 to facilitate the identification of causal effects in non-parametric models. The completeness proofs of [Huang and Valtorta, 2006] and [Shpitser and Pearl, 2006] and the graphical criteria of [Tian and…

Artificial Intelligence · Computer Science 2012-10-19 Judea Pearl

Constraint-based causal discovery is brittle in finite-sample regimes because erroneous conditional-independence (CI) decisions can cascade into substantial structural errors. We propose Quantitative Argumentation for Causal Discovery…

Artificial Intelligence · Computer Science 2026-04-28 Sheng Wei , Yulin Chen , Beishui Liao

Recent advances in Vision-Language Models (VLMs) have demonstrated impressive capabilities in perception and reasoning. However, the ability to perform causal inference -- a core aspect of human cognition -- remains underexplored,…

Computation and Language · Computer Science 2025-08-14 Keummin Ka , Junhyeong Park , Jaehyun Jeon , Youngjae Yu

Current causal text mining datasets vary in objectives, data coverage, and annotation schemes. These inconsistent efforts prevent modeling capabilities and fair comparisons of model performance. Furthermore, few datasets include…

Computation and Language · Computer Science 2023-04-17 Fiona Anting Tan , Xinyu Zuo , See-Kiong Ng

Causal analysis has become an essential component in understanding the underlying causes of phenomena across various fields. Despite its significance, existing literature on causal discovery algorithms is fragmented, with inconsistent…

Artificial Intelligence · Computer Science 2024-09-05 Wenjin Niu , Zijun Gao , Liyan Song , Lingbo Li

We introduce CausaLab, a scalable environment for evaluating interactive causal discovery by LLM agents. Unlike prior evaluations, CausaLab evaluates both whether an agent can solve a problem using causal evidence and whether its answer is…

Artificial Intelligence · Computer Science 2026-05-29 Junlin Yang , Dylan Zhang , Xiangchen Song , Qirun Dai , Xiao Liu , Yuen Chen , Aniket Vashishtha , Jing Shi , Chenhao Tan , Hao Peng

Large visual language models (VLMs) have shown strong multi-modal medical reasoning ability, but most operate as end-to-end black boxes, diverging from clinicians' evidence-based, staged workflows and hindering clinical accountability.…

Artificial Intelligence · Computer Science 2026-03-12 Yuexi Du , Jinglu Wang , Shujie Liu , Nicha C. Dvornek , Yan Lu

Clinical decision-making is a feedback system where risk estimates influence treatment, which in turn changes disease trajectories, and both shape clinicians' measurement practices. Static prediction often fails clinically: models trained…

Artificial Intelligence · Computer Science 2026-05-19 Pujun Feng , Xiaoyu Guo , Seyed Ehsan Saffari , Min Hun Lee , Siew-Kei Lam , Erik Cambria , Xibin Sun , Yangtao Zhou , Tong Yang , Xiaoyu Zhang , Tao Tan , Yue Sun , Bin Cui
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