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Autonomous agents have recently achieved remarkable progress across diverse domains, yet most evaluations focus on short-horizon, fully observable tasks. In contrast, many critical real-world tasks, such as large-scale software development,…

We present M-Reason, a demonstration system for transparent, agent-based reasoning and evidence integration in the biomedical domain, with a focus on cancer research. M-Reason leverages recent advances in large language models (LLMs) and…

Artificial Intelligence · Computer Science 2025-10-08 Oskar Wysocki , Magdalena Wysocka , Mauricio Jacobo , Harriet Unsworth , André Freitas

Many problems within personalized medicine and digital health rely on the analysis of continuous-time functional biomarkers and other complex data structures emerging from high-resolution patient monitoring. In this context, this work…

Machine Learning · Statistics 2025-01-14 Marcos Matabuena

Most reported gains on agentic-LLM clinical benchmarks are often attributed to prompt engineering, yet our results suggest that larger improvements can come from architectural and engine-level design. We present MDIA, a Multi-agent…

Artificial Intelligence · Computer Science 2026-05-26 Roberto Cruz , David Rey-Blanco

Simulating high-fidelity patients offers a powerful avenue for studying complex diseases while addressing the challenges of fragmented, biased, and privacy-restricted real-world data. In this study, we introduce SynthAgent, a novel…

Artificial Intelligence · Computer Science 2026-02-10 Arman Aghaee , Sepehr Asgarian , Jouhyun Jeon

Rare diseases, despite their low individual incidence, collectively impact around 300 million people worldwide due to the vast number of diseases. The involvement of multiple organs and systems, and the shortage of specialized doctors with…

Computation and Language · Computer Science 2025-11-11 Xuanzhong Chen , Ye Jin , Xiaohao Mao , Lun Wang , Shuyang Zhang , Ting Chen

Obesity, the leading cause of many non-communicable diseases, occurs mainly for eating more than our body requirements and lack of proper activity. So, being healthy requires heathy diet plans, especially for patients with comorbidities.…

Machine Learning · Computer Science 2023-08-08 Mrinmoy Roy , Srabonti Das , Anica Tasnim Protity

Medical decision systems increasingly rely on data from multiple sources to ensure reliable and unbiased diagnosis. However, existing multimodal learning models fail to achieve this goal because they often ignore two critical challenges.…

Machine Learning · Computer Science 2025-10-10 Md Zubair , Hao Zheng , Nussdorf Jonathan , Grayson W. Armstrong , Lucy Q. Shen , Gabriela Wilson , Yu Tian , Xingquan Zhu , Min Shi

Large language models (LLMs) excel at rapid generation of text and multimodal content, yet they falter on transaction-style planning that demands ACID-like guarantees and real-time disruption recovery. We present Adaptive LLM Agent System…

Artificial Intelligence · Computer Science 2025-05-20 Edward Y. Chang , Longling Geng

The rise of Large Language Models (LLMs) has enabled the development of specialized AI agents with domain-specific reasoning and interaction capabilities, particularly in healthcare. While recent frameworks simulate medical decision-making,…

Artificial Intelligence · Computer Science 2025-07-04 Tianqi Shang , Weiqing He , Charles Zheng , Lingyao Li , Li Shen , Bingxin Zhao

Comorbid chronic conditions are common among people with type 2 diabetes. We developed an Artificial Intelligence algorithm, based on Reinforcement Learning (RL), for personalized diabetes and multi-morbidity management with strong…

Computers and Society · Computer Science 2020-11-05 Hua Zheng , Ilya O. Ryzhov , Wei Xie , Judy Zhong

Large Language Models (LLMs) have shown remarkable capabilities as autonomous agents, yet existing benchmarks either focus on single-agent tasks or are confined to narrow domains, failing to capture the dynamics of multi-agent coordination…

Multiagent Systems · Computer Science 2025-03-05 Kunlun Zhu , Hongyi Du , Zhaochen Hong , Xiaocheng Yang , Shuyi Guo , Zhe Wang , Zhenhailong Wang , Cheng Qian , Xiangru Tang , Heng Ji , Jiaxuan You

Large-scale heterogeneous multiagent systems feature various realistic factors in the real world, such as agents with diverse abilities and overall system cost. In comparison to homogeneous systems, heterogeneous systems offer significant…

Artificial Intelligence · Computer Science 2024-03-28 Qingxu Fu , Zhiqiang Pu , Min Chen , Tenghai Qiu , Jianqiang Yi

Hallucinations remain a significant challenge in current Generative AI models, undermining trust in AI systems and their reliability. This study investigates how orchestrating multiple specialized Artificial Intelligent Agents can help…

Computation and Language · Computer Science 2025-01-27 Diego Gosmar , Deborah A. Dahl

Matching patients effectively and efficiently for clinical trials is a significant challenge due to the complexity and variability of patient profiles and trial criteria. This paper introduces \textbf{Multi-Agent for Knowledge Augmentation…

Multiagent Systems · Computer Science 2026-05-19 Hanwen Shi , Jin Zhang , Kunpeng Zhang

The rapid evolution of artificial intelligence (AI) has shifted from static, data-driven models to dynamic systems capable of perceiving and interacting with real-world environments. Despite advancements in pattern recognition and symbolic…

Achieving a just and sustainable transition requires the pursuit of multiple social and environmental targets. Two primary barriers impede this process: (1) targets are often in conflict with each other, and (2) policies aimed at these…

Acute poly-substance intoxication requires rapid, life-saving decisions under substantial uncertainty, as clinicians must rely on incomplete ingestion details and nonspecific symptoms. Effective diagnostic reasoning in this chaotic…

Computation and Language · Computer Science 2026-04-01 Nico Oberländer , David Bani-Harouni , Tobias Zellner , Nassir Navab , Florian Eyer , Matthias Keicher

This study aims to optimize meal planning for nutritional health and cost efficiency using linear programming. Linear optimization provides an effective framework for addressing the problem of an optimal diet, as the composition of food can…

Numerical Analysis · Mathematics 2025-01-09 Utkarsh Prajapati , Tanushree Jain , Abhishek Machiraju , Divyam Kaushik

Large Language Models (LLMs) like GPT-4 have revolutionized natural language processing, showing remarkable linguistic proficiency and reasoning capabilities. However, their application in strategic multi-agent decision-making environments…

Computation and Language · Computer Science 2024-05-29 Chuanhao Li , Runhan Yang , Tiankai Li , Milad Bafarassat , Kourosh Sharifi , Dirk Bergemann , Zhuoran Yang