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Building blocks of life such as amino acids, nucleobases, and fatty acids are central to prebiotic chemistry and represent key targets in the search for planetary biosignatures. In planetary materials, biomolecules typically occur at trace…

Earth and Planetary Astrophysics · Physics 2026-03-31 Xiaoou Luo , Chao He , Zhengbo Yang , Yingjian Wang , Ziyao Fang , Yu Liu , Sai Wang , Haixin Li

Ocean worlds are considered as targets for life detection missions because they meet several key requirements for habitability. However, identifying potential life on other worlds requires observing clear and unambiguous biosignature…

Earth and Planetary Astrophysics · Physics 2026-05-18 Peter M. Higgins , Weibin Chen , Oliver Warr , Lucas M. Fifer , Wanying Kang , Charles S. Cockell , Barbara Sherwood Lollar

In the modern search for life elsewhere in the Universe, we are broadly looking for the following: the planets similar to Earth - physical indicators of habitability, and the manifestation of life - the biological signatures. A biosignature…

Popular Physics · Physics 2021-03-31 Margarita Safonova , Alfia Saini

The Habitable Worlds Observatory (HWO) aims to characterize habitable exoplanets in search of signs of life. However, detectable life may be rare, either because abiogenesis is intrinsically contingent and unlikely, or because biospheres…

Instrumentation and Methods for Astrophysics · Physics 2025-07-02 Sukrit Ranjan , Danica Adams , Michael Wong , Martin Schlecker , Nicholas Wogan , Jessica M. Weber

Executive Summary: The Habitable Worlds Observatory (HWO) is the first astrophysics flagship mission with a key cross-divisional astrobiology science goal of searching for signs of life on rocky planets beyond our solar system. The Living…

The investigation of the emergence of life is a major endeavour of science. Astronomy is contributing to it in three fundamental manners: (1) by measuring the chemical enrichment of the Universe, (2) by investigating planet formation and…

The identification of extraterrestrial life is one the most exciting and challenging endeavors in space research. The existence of extinct or extant life can be inferred from biogenic elements, isotopes, and molecules, but accurate and…

The discovery of inhabited exoplanets hinges on identifying biosignature gases. JWST can reveal biosignature gases, though current discoveries have yet to evidence life. The central challenge is attribution: how can we confidently identify…

Earth and Planetary Astrophysics · Physics 2026-02-17 Tereza Constantinou , Oliver Shorttle , Miles Cranmer , Paul B. Rimmer

Finding life on exoplanets from telescopic observations is an ultimate goal of exoplanet science. Life produces gases and other substances, such as pigments, which can have distinct spectral or photometric signatures. Whether or not life is…

One thing that discriminates living things from inanimate matter is their ability to generate similarly complex or non-random architectures in a large abundance. From DNA sequences to folded protein structures, living cells, microbial…

Other Quantitative Biology · Quantitative Biology 2018-02-07 Stuart M. Marshall , Alastair R. G. Murray , Leroy Cronin

The search for potentially habitable exoplanets centers on detecting biosignature molecules in Earth-like atmospheres, which makes it essential to understand their detectability under biologically and geologically influenced conditions. In…

Earth and Planetary Astrophysics · Physics 2025-12-12 Dibya Bharati Pradhan , Priyankush Ghosh , Oommen P. Jose , Liton Majumdar

This white paper introduces a framework for applying Assembly Theory (AT) to planetary atmospheres as a biosignature framework suitable for the Habitable Worlds Observatory (HWO). AT quantifies the minimum combinatorial complexity required…

Instrumentation and Methods for Astrophysics · Physics 2026-04-07 Sara Walker , Estelle Janin , Evgenya Shkolnik , Louie Slocombe , Leroy Cronin

Long-lived particles (LLPs), i.e., particles with macroscopic lifetimes $\tau>10$~ns, appear in various extensions of the Standard Model (SM) that address fundamental questions like the particulate nature of dark matter or baryogenesis. The…

High Energy Physics - Experiment · Physics 2025-11-03 ANUBIS Collaboration

Organisms leave a distinctive chemical signature in their environment because they synthesize those molecules that maximize their fitness. As a result, the relative concentrations of related chemical monomers in life-bearing environmental…

Biomolecules · Quantitative Biology 2011-05-05 Evan D. Dorn , Kenneth H. Nealson , Christoph Adami

An important future goal in exoplanetology is to detect and characterize potentially habitable planets. Using nulling interferometry, LIFE will allow us to constrain the radius and effective temperature of (terrestrial) exoplanets, as well…

The near-term capability to characterize terrestrial exoplanet atmospheres may bring us closer to discovering alien life through atmospheric data. However, remotely detectable candidate biosignature gases are subject to false positive…

Earth and Planetary Astrophysics · Physics 2025-04-25 Theresa Fisher , Estelle Janin , Sara Imari Walker

Modern machine learning methods have been proposed to detect life in extraterrestrial samples, drawing on their ability to distinguish biotic from abiotic samples based on training models using natural and synthetic organic molecular…

Machine Learning · Computer Science 2026-04-15 Ankit Gupta , Christoph Adami

The search for life in the Solar System hinges on data from planetary missions. Detecting biosignatures based on molecular identity, isotopic composition, or chiral excess requires measurements that current and planned missions can only…

Earth and Planetary Astrophysics · Physics 2026-04-10 Gideon Yoffe , Fabian Klenner , Barak Sober , Yohai Kaspi , Itay Halevy

Since its inception six decades ago, astrobiology has diversified immensely to encompass several scientific questions including the origin and evolution of Terran life, the organic chemical composition of extraterrestrial objects, and the…

We investigate how well the Large Interferometer for Exoplanets (LIFE) mission concept can detect habitable conditions on exoplanets through the presence of atmospheric water vapor as a proxy for surface oceans. We model the atmosphere of a…

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