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In digital pathology, segmenting densely distributed objects like glands and nuclei is crucial for downstream analysis. Since detailed pixel-wise annotations are very time-consuming, we need semi-supervised segmentation methods that can…

Image and Video Processing · Electrical Eng. & Systems 2024-07-18 Meilong Xu , Xiaoling Hu , Saumya Gupta , Shahira Abousamra , Chao Chen

Raman spectroscopy, a photonic modality based on the inelastic backscattering of coherent light, is a valuable asset to the intraoperative sensing space, offering non-ionizing potential and highly-specific molecular fingerprint-like…

Image and Video Processing · Electrical Eng. & Systems 2024-01-18 Ashutosh Raman , Ren A. Odion , Kent K. Yamamoto , Weston Ross , Tuan Vo-Dinh , Patrick J. Codd

The diagnosis of prostate cancer is challenging due to the heterogeneity of its presentations, leading to the over diagnosis and treatment of non-clinically important disease. Accurate diagnosis can directly benefit a patient's quality of…

Raman spectroscopy enables non-destructive, label-free imaging with unprecedented molecular contrast but is limited by slow data acquisition, largely preventing high-throughput imaging applications. Here, we present a comprehensive…

Image and Video Processing · Electrical Eng. & Systems 2021-12-02 Conor C. Horgan , Magnus Jensen , Anika Nagelkerke , Jean-Phillipe St-Pierre , Tom Vercauteren , Molly M. Stevens , Mads S. Bergholt

At present, cancer is one of the most important health issues in the world. Because early detection and appropriate treatment in cancer are very effective in the recovery and survival of patients, image processing as a diagnostic tool can…

Image and Video Processing · Electrical Eng. & Systems 2022-02-17 Reza Zare , Arash Pourkazemi

"Is it possible to predict expression levels of different genes at a given spatial location in the routine histology image of a tumor section by modeling its stain absorption characteristics?" In this work, we propose a "stain-aware"…

Image and Video Processing · Electrical Eng. & Systems 2021-08-27 Muhammad Dawood , Kim Branson , Nasir M. Rajpoot , Fayyaz ul Amir Afsar Minhas

Few-shot learning is a standard practice in most deep learning based histopathology image segmentation, given the relatively low number of digitized slides that are generally available. While many models have been developed for domain…

Image and Video Processing · Electrical Eng. & Systems 2021-10-01 Zheng Yuan , Andre Esteva , Ran Xu

In this paper, we introduce an unsupervised cancer segmentation framework for histology images. The framework involves an effective contrastive learning scheme for extracting distinctive visual representations for segmentation. The encoder…

Computer Vision and Pattern Recognition · Computer Science 2022-06-20 Yilong Li , Yaqi Wang , Huiyu Zhou , Huaqiong Wang , Gangyong Jia , Qianni Zhang

Digitized Histological diagnosis is in increasing demand. However, color variations due to various factors are imposing obstacles to the diagnosis process. The problem of stain color variations is a well-defined problem with many proposed…

Computer Vision and Pattern Recognition · Computer Science 2018-04-06 M Tarek Shaban , Christoph Baur , Nassir Navab , Shadi Albarqouni

Raman spectroscopy provides a vibrational profile of the molecules and thus can be used to uniquely identify different kind of materials. This sort of fingerprinting molecules has thus led to widespread application of Raman spectrum in…

Early diagnosis of the cancer cells is necessary for making an effective treatment plan and for the health and safety of a patient. Nowadays, doctors usually use a histological grade that pathologists determine by performing a…

Computer Vision and Pattern Recognition · Computer Science 2023-11-15 Varan Singh Rohila , Neeraj Lalwani , Lochan Basyal

AI-assisted nuclei segmentation in histopathological images is a crucial task in the diagnosis and treatment of cancer diseases. It decreases the time required to manually screen microscopic tissue images and can resolve the conflict…

Image and Video Processing · Electrical Eng. & Systems 2023-11-21 Hesham Ali , Idriss Tondji , Mennatullah Siam

Conventional haematoxylin, eosin and saffron (HES) histopathology, currently the gold-standard for pathological diagnosis of cancer, requires extensive sample preparations that are achieved within time scales that are not compatible with…

Diagnostic pathology, which is the basis and gold standard of cancer diagnosis, provides essential information on the prognosis of the disease and vital evidence for clinical treatment. Tumor region detection, subtype and grade…

Image and Video Processing · Electrical Eng. & Systems 2021-10-27 Jialun Wu , Haichuan Zhang , Zeyu Gao , Xinrui Bao , Tieliang Gong , Chunbao Wang , Chen Li

Deep Neural Networks (DNNs) are widely used for decision making in a myriad of critical applications, ranging from medical to societal and even judicial. Given the importance of these decisions, it is crucial for us to be able to interpret…

Computer Vision and Pattern Recognition · Computer Science 2022-11-28 Teddy Koker , Fatemehsadat Mireshghallah , Tom Titcombe , Georgios Kaissis

Histopathology nuclei segmentation is crucial for quantitative tissue analysis and cancer diagnosis. Although existing segmentation methods have achieved strong performance, they are often computationally heavy and show limited…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Muhammad Hassan Maqsood , Yanming Zhu , Alfred Lam , Getamesay Dagnaw , Xuefei Yin , Alan Wee-Chung Liew

Skin Cancer is one of the most deathful of all the cancers. It is bound to spread to different parts of the body on the off chance that it is not analyzed and treated at the beginning time. It is mostly because of the abnormal growth of…

Machine Learning · Computer Science 2019-12-10 Rishu Garg , Saumil Maheshwari , Anupam Shukla

Accurate nuclei segmentation in histopathological images is crucial for cancer diagnosis. Automating this process offers valuable support to clinical experts, as manual annotation is time-consuming and prone to human errors. However,…

Computer Vision and Pattern Recognition · Computer Science 2024-06-13 Ayush Roy , Payel Pramanik , Dmitrii Kaplun , Sergei Antonov , Ram Sarkar

Raman spectroscopy enables non-destructive, label-free molecular analysis with high specificity, making it a powerful tool for biomedical diagnostics. However, its application to biological tissues is challenged by inherently weak Raman…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Mengkun Chen , Sanidhya D. Tripathi , James W. Tunnell

Histopathology remains the gold standard for cancer diagnosis because it provides detailed cellular-level assessment of tissue morphology. However, manual histopathological examination is time-consuming, labour-intensive, and subject to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Ravi Mosalpuri , Mohammed Abdelsamea , Ahmed Karam Eldaly
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