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Generalizing to unseen graph tasks without task-specific supervision is challenging: conventional graph neural networks are typically tied to a fixed label space, while large language models (LLMs) struggle to capture graph structure. We…

Machine Learning · Computer Science 2025-10-21 Duo Wang , Yuan Zuo , Guangyue Lu , Junjie Wu

Objective: Identifying study-eligible patients within clinical databases is a critical step in clinical research. However, accurate query design typically requires extensive technical and biomedical expertise. We sought to create a system…

Computation and Language · Computer Science 2023-08-16 Nicholas J Dobbins , Bin Han , Weipeng Zhou , Kristine Lan , H. Nina Kim , Robert Harrington , Ozlem Uzuner , Meliha Yetisgen

Large language models (LLMs) have revolutionized natural language processing (NLP), particularly through Retrieval-Augmented Generation (RAG), which enhances LLM capabilities by integrating external knowledge. However, traditional RAG…

Computation and Language · Computer Science 2025-10-23 Nengbo Wang , Xiaotian Han , Jagdip Singh , Jing Ma , Vipin Chaudhary

Large Language Models (LLMs) and Knowledge Graphs (KGs) offer a promising approach to robust and explainable Question Answering (QA). While LLMs excel at natural language understanding, they suffer from knowledge gaps and hallucinations.…

Machine Learning · Computer Science 2025-04-15 Jasper Linders , Jakub M. Tomczak

Recent works have made notable advancements in enhancing unified models for text-to-image generation through the Chain-of-Thought (CoT). However, these reasoning methods separate the processes of understanding and generation, which limits…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Yuanhuiyi Lyu , Chi Kit Wong , Chenfei Liao , Lutao Jiang , Xu Zheng , Zexin Lu , Linfeng Zhang , Xuming Hu

Knowledge Graph-based Retrieval-Augmented Generation (KG-RAG) significantly enhances the reasoning capabilities of LargeLanguage Models by leveraging structured knowledge. However, existing KG-RAG frameworks typically operate as open-loop…

Information Retrieval · Computer Science 2025-08-14 Xujie Yuan , Shimin Di , Jielong Tang , Libin Zheng , Jian Yin

Graph retrieval-augmented generation (GraphRAG) has effectively enhanced large language models in complex reasoning by organizing fragmented knowledge into explicitly structured graphs. Prior efforts have been made to improve either graph…

Information Retrieval · Computer Science 2025-09-04 Junnan Dong , Siyu An , Yifei Yu , Qian-Wen Zhang , Linhao Luo , Xiao Huang , Yunsheng Wu , Di Yin , Xing Sun

Biomedical knowledge graphs are increasingly large, dynamic, and multimodal, driven by rapid advances in biotechnology such as high-throughput sequencing. Machine learning models can infer previously unobserved biomedical relationships and…

Machine Learning · Computer Science 2026-05-12 Yousef A. Radwan , Yao Li , Qing Qing , Ziqi Xu , Qixin Zhang , Yongcheng Jing , Renqiang Luo , Xikun Zhang

The Quantum-Inspired Stacked Integrated Concept Graph Model (QISICGM) is an innovative machine learning framework that harnesses quantum-inspired techniques to predict diabetes risk with exceptional accuracy and efficiency. Utilizing the…

Machine Learning · Computer Science 2025-09-17 Kenneth G. Young

Accurate yet interpretable image-based diagnosis remains a central challenge in medical AI, particularly in settings characterized by limited data, subtle visual cues, and high-stakes clinical decision-making. Most existing vision models…

Artificial Intelligence · Computer Science 2025-12-23 Midhat Urooj , Ayan Banerjee , Sandeep Gupta

Clinical value set authoring -- the task of identifying all codes in a standardized vocabulary that define a clinical concept -- is a recurring bottleneck in clinical quality measurement and phenotyping. A natural approach is to prompt a…

Computation and Language · Computer Science 2026-04-17 Sumit Mukherjee , Juan Shu , Nairwita Mazumder , Tate Kernell , Celena Wheeler , Shannon Hastings , Chris Sidey-Gibbons

Biomedical literature and clinical narratives pose multifaceted challenges for natural language understanding, from precise entity extraction and document synthesis to multi-step diagnostic reasoning. This study extends a unified benchmark…

Computation and Language · Computer Science 2025-10-24 Yu Hou , Zaifu Zhan , Min Zeng , Yifan Wu , Shuang Zhou , Rui Zhang

Language models traditionally used for cross-domain generalization have recently demonstrated task-specific reasoning. However, their top-down training approach on general corpora is insufficient for acquiring abstractions needed for deep…

Computation and Language · Computer Science 2025-09-03 Bhishma Dedhia , Yuval Kansal , Niraj K. Jha

Manually curated biomedical repositories -- spanning bioactivity, genomics, and chemistry -- are expensive to maintain, lag behind primary literature, and discard experimental context, obscuring nuances needed to assess data correctness and…

Knowledge Graphs (KGs) have shown to be very important for applications such as personal assistants, question-answering systems, and search engines. Therefore, it is crucial to ensure their high quality. However, KGs inevitably contain…

Databases · Computer Science 2022-08-18 Elwin Huaman , Dieter Fensel

Background : Knowledge is evolving over time, often as a result of new discoveries or changes in the adopted methods of reasoning. Also, new facts or evidence may become available, leading to new understandings of complex phenomena. This is…

Computation and Language · Computer Science 2023-04-24 Ayoub Harnoune , Maryem Rhanoui , Mounia Mikram , Siham Yousfi , Zineb Elkaimbillah , Bouchra El Asri

Large language models (LLMs) are rapidly transforming various domains, including biomedicine and healthcare, and demonstrate remarkable potential from scientific research to new drug discovery. Graph-based retrieval-augmented generation…

Quantitative Methods · Quantitative Biology 2025-11-14 Guofeng Meng , Li Shen , Qiuyan Zhong , Wei Wang , Haizhou Zhang , Xiaozhen Wang

In the domain of Natural Language Processing (NLP), Large Language Models (LLMs) have demonstrated promise in text-generation tasks. However, their educational applications, particularly for domain-specific queries, remain underexplored.…

Computation and Language · Computer Science 2024-02-23 Rui Yang , Boming Yang , Sixun Ouyang , Tianwei She , Aosong Feng , Yuang Jiang , Freddy Lecue , Jinghui Lu , Irene Li

The need for robust and diverse data sets to train clinical large language models (cLLMs) is critical given that currently available public repositories often prove too limited in size or scope for comprehensive medical use. While resources…

Biomedical documents such as Electronic Health Records (EHRs) contain a large amount of information in an unstructured format. The data in EHRs is a hugely valuable resource documenting clinical narratives and decisions, but whilst the text…

Computation and Language · Computer Science 2019-12-24 Zeljko Kraljevic , Daniel Bean , Aurelie Mascio , Lukasz Roguski , Amos Folarin , Angus Roberts , Rebecca Bendayan , Richard Dobson
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