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Recent advancements in Large Language Models (LLMs) have demonstrated significant promise in clinical diagnosis. However, current models struggle to emulate the iterative, diagnostic hypothesis-driven reasoning of real clinical scenarios.…

Computation and Language · Computer Science 2026-01-06 Qipeng Wang , Rui Sheng , Yafei Li , Huamin Qu , Yushi Sun , Min Zhu

Large language models (LLMs) are increasingly used in the mental health domain, yet it remains unclear how well they capture related biomedical knowledge and how reliably they apply it to clinically salient structured judgments. Here, we…

Computation and Language · Computer Science 2026-05-18 Weixin Liu , Congning Ni , Shelagh A. Mulvaney , Susannah L. Rose , Murat Kantarcioglu , Bradley A. Malin , Zhijun Yin

Clinical question answering systems have the potential to provide clinicians with relevant and timely answers to their questions. Nonetheless, despite the advances that have been made, adoption of these systems in clinical settings has been…

Large language models (LLMs) are rapidly transforming various domains, including biomedicine and healthcare, and demonstrate remarkable potential from scientific research to new drug discovery. Graph-based retrieval-augmented generation…

Quantitative Methods · Quantitative Biology 2025-11-14 Guofeng Meng , Li Shen , Qiuyan Zhong , Wei Wang , Haizhou Zhang , Xiaozhen Wang

In this work, we propose Oph-Guid-RAG, a multimodal visual RAG system for ophthalmology clinical question answering and decision support. We treat each guideline page as an independent evidence unit and directly retrieve page images,…

Artificial Intelligence · Computer Science 2026-03-24 Shuying Chen , Sen Cui , Zhong Cao

Biomedical Question Answering aims to obtain an answer to the given question from the biomedical domain. Due to its high requirement of biomedical domain knowledge, it is difficult for the model to learn domain knowledge from limited…

Computation and Language · Computer Science 2022-06-29 Yuxuan Lu , Jingya Yan , Zhixuan Qi , Zhongzheng Ge , Yongping Du

Querying knowledge graphs (KGs) using deep learning approaches can naturally leverage the reasoning and generalization ability to learn to infer better answers. Traditional neural complex query answering (CQA) approaches mostly work on…

Computation and Language · Computer Science 2023-10-30 Jiaxin Bai , Xin Liu , Weiqi Wang , Chen Luo , Yangqiu Song

Recently, there has been an increase in the number of knowledge graphs that can be only queried by experts. However, describing questions using structured queries is not straightforward for non-expert users who need to have sufficient…

Computation and Language · Computer Science 2021-05-04 Abdelghny Orogat , Isabelle Liu , Ahmed El-Roby

Dermatological care via telemedicine often lacks the rich context of in-person visits. Clinicians must make diagnoses based on a handful of images and brief descriptions, without the benefit of physical exams, second opinions, or reference…

Artificial Intelligence · Computer Science 2025-08-27 Karishma Thakrar , Shreyas Basavatia , Akshay Daftardar

Clinical practice guidelines (CPGs) encode evidence-based decision logic that clinicians apply by evaluating patient variables, conditional criteria, and recommendation rules. However, existing methods often use CPGs as free-text training…

Artificial Intelligence · Computer Science 2026-05-27 Yuhao Shen , Lang Cao , Simo Du , Yuqing Wang , Juexiao Zhou , Hao Peng , Yue Guo

We study asynchronous alignment, a first-class multimodal learning setting in which a dense primary stream must be fused with sporadic external context whose value depends on when it arrives. Unlike standard multimodal benchmarks that…

Machine Learning · Computer Science 2026-04-21 Yunxiang Guo

Dealing with context dependent knowledge has led to different formalizations of the notion of context. Among them is the Contextualized Knowledge Repository (CKR) framework, which is rooted in description logics but links on the reasoning…

Artificial Intelligence · Computer Science 2021-12-23 Loris Bozzato , Thomas Eiter , Rafael Kiesel

Medical reasoning in large language models (LLMs) aims to emulate clinicians' diagnostic thinking, but current benchmarks such as MedQA-USMLE, MedMCQA, and PubMedQA often mix reasoning with factual recall. We address this by separating 11…

We study the problem of multilingual automated reply suggestions (RS) model serving many languages simultaneously. Multilingual models are often challenged by model capacity and severe data distribution skew across languages. While prior…

Computation and Language · Computer Science 2021-09-16 Budhaditya Deb , Guoqing Zheng , Milad Shokouhi , Ahmed Hassan Awadallah

Large Language Models (LLMs) have significantly advanced medical question-answering by leveraging extensive clinical data and medical literature. However, the rapid evolution of medical knowledge and the labor-intensive process of manually…

Computation and Language · Computer Science 2025-07-01 Mohammad Reza Rezaei , Reza Saadati Fard , Jayson L. Parker , Rahul G. Krishnan , Milad Lankarany

Evaluating natural language generation (NLG) systems in the medical domain presents unique challenges due to the critical demands for accuracy, relevance, and domain-specific expertise. Traditional automatic evaluation metrics, such as…

Computation and Language · Computer Science 2025-09-17 Wen-wai Yim , Asma Ben Abacha , Zixuan Yu , Robert Doerning , Fei Xia , Meliha Yetisgen

Large Language Models (LLMs) have demonstrated significant potential across various domains. However, they often struggle with integrating external knowledge and performing complex reasoning, leading to hallucinations and unreliable…

Machine Learning · Computer Science 2025-11-25 Yao Cheng , Yibo Zhao , Jiapeng Zhu , Yao Liu , Xing Sun , Xiang Li

Retrieval-Augmented Generation (RAG) has become a core paradigm in document question answering tasks. However, existing methods have limitations when dealing with multimodal documents: one category of methods relies on layout analysis and…

Computation and Language · Computer Science 2026-03-09 Wang Chen , Wenhan Yu , Guanqiang Qi , Weikang Li , Yang Li , Lei Sha , Deguo Xia , Jizhou Huang

Knowledge graphs (KGs) are increasingly used to support large lan guage model (LLM) reasoning, but standard triplet-based KGs treat each relation as globally valid. In many settings, whether a relation should count as evidence depends on…

Computation and Language · Computer Science 2026-04-28 Yao Wang , Zixu Geng , Jun Yan

The AI2 Reasoning Challenge (ARC), a new benchmark dataset for question answering (QA) has been recently released. ARC only contains natural science questions authored for human exams, which are hard to answer and require advanced logic…

Machine Learning · Computer Science 2018-06-01 Yuyu Zhang , Hanjun Dai , Kamil Toraman , Le Song
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