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The discovery of inorganic crystal structures with targeted properties is a significant challenge in materials science. Generative models, especially state-of-the-art diffusion models, offer the promise of modeling complex data…

Crystal structures are defined by the periodic arrangement of atoms in 3D space, inherently making them equivariant to SO(3) group. A fundamental requirement for crystal property prediction is that the model's output should remain invariant…

Computational Engineering, Finance, and Science · Computer Science 2025-10-24 Haowei Hua , Wanyu Lin

Unconditional crystal structure generation with diffusion models faces challenges in identifying symmetric crystals as the unit cell size increases. We present the Crystal Host-Guided Generation (CHGGen) framework to address this challenge…

Materials Science · Physics 2025-09-09 Peichen Zhong , Xinzhe Dai , Bowen Deng , Gerbrand Ceder , Kristin A. Persson

Crystal structure generation is fundamental to materials science, enabling the discovery of novel materials with desired properties. While existing approaches leverage Large Language Models (LLMs) through extensive fine-tuning on materials…

Determining whether a candidate crystalline material is thermodynamically stable depends on identifying its true ground-state structure, a central challenge in computational materials science. We introduce CrystalGRW, a diffusion-based…

Crystalline structure prediction is an essential prerequisite for designing materials with targeted properties. Yet, it is still an open challenge in materials design and drug discovery. Despite recent advances in computational materials…

Machine Learning · Computer Science 2025-09-29 Emmanuel Jehanno , Romain Menegaux , Julien Mairal , Sergei Grudinin

We have developed an efficient and reliable methodology for crystal structure prediction, merging ab initio total-energy calculations and a specifically devised evolutionary algorithm. This method allows one to predict the most stable…

Materials Science · Physics 2009-11-18 A. R. Oganov , C. W. Glass

Molecular crystal structure prediction (CSP) seeks the most stable periodic structure given the chemical composition of a molecule and pressure-temperature conditions. Modern CSP solvers use global optimization methods to search for…

Optimization and Control · Mathematics 2023-02-21 Miloslav Torda , John Y. Goulermas , Roland Púček , Vitaliy Kurlin

Crystal structure prediction (CSP) is a useful tool in pharmaceutical development for identifying and assessing risks associated with polymorphism, yet widespread adoption has been hindered by high computational costs and the need for both…

Chemical Physics · Physics 2025-07-23 Zachary L. Glick , Derek P. Metcalf , Scott F. Swarthout

Discovering materials with new structural chemistry is key to achieving transformative functionality. Generative artificial intelligence offers a scalable route to propose candidate crystal structures. We introduce a reliable low-cost proxy…

Generating irreducible site-occupancy configurations by taking advantage of crystal symmetry is a ubiquitous method for accelerating of disordered structure prediction, which plays an important role in condensed matter physics and material…

Computational Physics · Physics 2020-10-28 Ji-Chun Lian , Hong-Yu Wu , Wei-Qing Huang , Wangyu Hu , Gui-Fang Huang

In this study, we present a novel approach along with the needed computational strategies for efficient and scalable feature engineering of the crystal structure in compounds of different chemical compositions. This approach utilizes a…

Materials Science · Physics 2021-05-25 Prathik R. Kaundinya , Kamal Choudhary , Surya R. Kalidindi

Predicting which hypothetical inorganic crystals can be experimentally realized remains a central challenge in accelerating materials discovery. SyntheFormer is a positive-unlabeled framework that learns synthesizability directly from…

Materials Science · Physics 2025-10-23 Danial Ebrahimzadeh , Sarah Sharif , Yaser Mike Banad

Deep learning-based generative models have emerged as powerful tools for modeling complex data distributions and generating high-fidelity samples, offering a transformative approach to efficiently explore the configuration space of…

Materials Science · Physics 2025-11-12 Xiaoshan Luo , Zhenyu Wang , Qingchang Wang , Jian Lv , Lei Wang , Yanchao Wang , Yanming Ma

While crystal structure prediction (CSP) remains a longstanding challenge, we introduce ParetoCSP, a novel algorithm for CSP, which combines a multi-objective genetic algorithm (MOGA) with a neural network inter-atomic potential (IAP) model…

Materials Science · Physics 2023-09-14 Sadman Sadeed Omee , Lai Wei , Jianjun Hu

One of the greatest challenges facing our society is the discovery of new innovative crystal materials with specific properties. Recently, the problem of generating crystal materials has received increasing attention, however, it remains…

Materials Science · Physics 2023-06-08 Astrid Klipfel , Yaël Frégier , Adlane Sayede , Zied Bouraoui

Machine Learning (ML) techniques are revolutionizing the way to perform efficient materials modeling. Nevertheless, not all the ML approaches allow for the understanding of microscopic mechanisms at play in different phenomena. To address…

Materials Science · Physics 2022-06-22 Udaykumar Gajera , Loriano Storchi , Danila Amoroso , Francesco Delodovici , Silvia Picozzi

The constant demand for new functional materials calls for efficient strategies to accelerate the materials design and discovery. In addressing this challenge, machine learning generative models can offer promising opportunities since they…

Materials Science · Physics 2020-06-24 Sungwon Kim , Juhwan Noh , Geun Ho Gu , Alán Aspuru-Guzik , Yousung Jung

Prediction of stable crystal structures at given pressure-temperature conditions, based only on the knowledge of the chemical composition, is a central problem of condensed matter physics. This extremely challenging problem is often termed…

Materials Science · Physics 2015-05-20 A. R. Oganov , Y. Ma , A. O. Lyakhov , M. Valle , C. Gatti

Discovering functional crystalline materials entails navigating an immense combinatorial design space. While recent advances in generative artificial intelligence have enabled the sampling of chemically plausible compositions and…

Machine Learning · Computer Science 2025-11-11 Hyunsoo Park , Aron Walsh
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