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Injecting with needles causes fear, pain and contamination risks. Billions of injections every year also cause environmental burden in terms of material consumption and waste. Controlled microfluidic-jet injection systems offer a…

The development of needle-free drug injection systems is of great importance to global healthcare. However, in spite of its great potential and research history over many decades, these systems are not commonly used. One of the main…

Fluid Dynamics · Physics 2012-10-16 Yoshiyuki Tagawa , Nikolai Oudalov , A. El Ghalbzouri , Chao Sun , Detlef Lohse

A needle-free injector using a highly focused microjet has the potential to minimize the invasiveness of drug delivery. In this study, the jet penetration depth in a soft material-which is a critical parameter for practical needle-free…

Fluid Dynamics · Physics 2024-02-08 Daichi Igarashi , Kento Kimura , Nanami Endo , Yuto Yokoyama , Hiroaki Kusuno , Yoshiyuki Tagawa

Needle-free injector technology (NFIT) has drawn attention due to their advantages. By using NFIT, it can be used several time unlike a conventional needle. Also, it makes patients free from pain. Since NFIT by jet injection is achieved by…

Medical Physics · Physics 2020-02-27 Eun-Sung Jekal , David Cooper , Samantha Maier , Seonyoung Park

High speed microfluidic jets can be generated by a thermocavitation process: from the evaporation of the liquid inside a microfluidic channel, a rapidly expanding bubble is formed and generates a jet through a flow focusing effect. Here, we…

High speed imaging was used to capture the fast dynamics of two injection methods. The first one and perhaps the oldest known, is based on solid needles and used for dermal pigmentation, or tattooing. The second, is a novel needle-free…

Applied Physics · Physics 2019-05-01 Loreto Oyarte-Gálvez , Maria Brió Pérez , David Fernández Rivas

X-ray Free Electron Lasers (XFELs) can probe chemical and biological reactions as they unfold with unprecedented spatial and temporal resolution. A principal challenge in this pursuit is the delivery of samples to the X-ray interaction…

The amount of air entrained by vertical water jets impacting a large pool is revisited. To test available phenomenological models, new data on the jet deformation at impact and on the entrained air flow rate were collected both on a…

Fluid Dynamics · Physics 2024-11-11 Ivan Redor , Gregory Guyot , Martin Obligado , Jean-Philippe Matas , Alain Cartellier

In this study we present a kinematic approach to modeling needle insertion into soft tissues. The kinematic approach allows the presentation of the problem as Dirichlet-type (i.e. driven by enforced motion of boundaries) and therefore…

Medical Physics · Physics 2021-01-26 Adam Wittek , George Bourantas , Benjamin F. Zwick , Grand Joldes , Lionel Esteban , Karol Miller

Percutaneous needle insertions are commonly performed for diagnostic and therapeutic purposes as an effective alternative to more invasive surgical procedures. However, the outcome of needle-based approaches relies heavily on the accuracy…

Robotics · Computer Science 2023-12-01 Yanzhou Wang , Lidia Al-Zogbi , Guanyun Liu , Jiawei Liu , Junichi Tokuda , Axel Krieger , Iulian Iordachita

We investigated the effect of container shape on the behavior of the impact-induced focused liquid jets by dropping a converging-shaped container (e.g., Kjeldahl flask) partially filled with liquid onto a floor to develop a method for…

Fluid Dynamics · Physics 2025-06-16 Hiroya Watanabe , Hiroaki Kusuno , Yoshiyuki Tagawa

We conduct a series of experiments with a special interest on a penetration process and instabilities arisen on a liquid jet impinged to a liquid of the same kind flowing in a channel. The impinged jet penetrates into the flowing bath…

Fluid Dynamics · Physics 2010-10-18 Kaoru Hattori , Ichiro Ueno

We investigate the collision of a continuous liquid jet with a regular stream of immiscible droplets. The immiscible liquids, namely silicon oil for the continuous jet and an aqueous glycerol solution for the drop stream, are selected to…

Fluid Dynamics · Physics 2018-04-11 Carole Planchette , Hannes Hinterbichler , Günter Brenn

Penetration process and an instability on a liquid jet impinging to a stream of the same fluid in a channel is focused. The jet penetrated into the stream is wrapped by entrained air, and coalesces with the stream when the air sheath around…

Fluid Dynamics · Physics 2009-10-19 Naoto Oka , Ichiro Ueno

Illuminating a water solution with a focused continuous wave laser produces a strong local heating of the liquid that leads to the nucleation of bubbles, also known as thermocavitation. During the growth of the bubble, the surrounding…

Impulsively generated focused jets play a significant role in various applications, including inkjet printing, needle-free drug delivery, and microfluidic devices. As the demand for generating jets and droplets from medium to highly viscous…

Fluid Dynamics · Physics 2025-08-20 Xianggang Cheng , Xiao-Peng Chen , Hang Ding , Chun-Yu Zhang , Haibao Hu , Laibing Jia

Droplet impact is a fascinating phenomenon that occurs when a liquid droplet collides with a surface. It is not only a fundamental area of scientific inquiry but also has practical implications across many industries and natural systems.…

Fluid Dynamics · Physics 2026-03-27 Shubham Ganar , Arindam Das

We investigated the formation of granular focused jets defined as narrow upward ejections of grains triggered by impulsive forces and shaped by kinematic focusing on a concave free surface. The jets were generated from nonfluidized granular…

Soft Condensed Matter · Physics 2025-08-19 Kazuya U. Kobayashi , Pradipto , Yoshiyuki Tagawa

We study the deformation and dewetting of liquid films under impinging gas jets using experimental, analytical and numerical techniques. We first derive a reduced-order model (a thin-film equation) based on the long-wave assumption and on…

Fluid Dynamics · Physics 2020-12-02 C. J. Ojiako , R. Cimpeanu , H. Bandulasena , R. Smith , D. Tseluiko

In this paper we investigate the mechanical problem of piercing a soft solid body with a needle. This phenomenon is controlled by the critical condition of needle insertion. Needle insertion involves physical and geometrical nonlinearities…

Soft Condensed Matter · Physics 2024-12-16 Stefano Fregonese , Mattia Bacca
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