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Factorization machine with quadratic-optimization annealing (FMQA) is a black-box optimization method that combines a factorization machine (FM) surrogate with QUBO-based search by an Ising machine. When FMQA is applied to integer or…

Machine Learning · Computer Science 2026-05-07 Taiga Hayashi , Yuya Seki , Kotaro Terada , Yosuke Mukasa , Shuta Kikuchi , Shu Tanaka

Black-box (BB) optimization problems aim to identify an input that maximizes or minimizes the output of a function (the BB function) whose input-output relationship is unknown. Factorization machine with quadratic-optimization annealing…

Machine Learning · Computer Science 2026-01-27 Mayumi Nakano , Yuya Seki , Shuta Kikuchi , Shu Tanaka

In black-box combinatorial optimization, objective evaluations are often expensive, so high quality solutions must be found under a limited budget. Factorization machine with quantum annealing (FMQA) builds a quadratic surrogate model from…

Machine Learning · Computer Science 2026-02-11 Tetsuro Abe , Masashi Yamashita , Shu Tanaka

Black-box optimization (BBO) is used in materials design, drug discovery, and hyperparameter tuning in machine learning. The world is experiencing several of these problems. In this review, a factorization machine with quantum annealing or…

Statistical Mechanics · Physics 2026-04-30 Ryo Tamura , Yuya Seki , Yuki Minamoto , Koki Kitai , Yoshiki Matsuda , Shu Tanaka , Koji Tsuda

Quantum computing and machine learning are state-of-the-art technologies that have been investigated intensively in both academia and industry. The hybrid technology of these two ingredients is expected to be a powerful tool to solve…

Quantum Physics · Physics 2026-03-05 Yusuke Hama , Tadashi Kadowaki

It is the first step for understanding how RNA structure folds from base sequences that to know how its secondary structure is formed. Traditional energy-based algorithms are short of precision, particularly for non-nested sequences, while…

Quantum Physics · Physics 2023-05-18 Ji Jiang , Qipeng Yan , Ye Li , Min Lu , Ziwei Cui , Menghan Dou , Qingchun Wang , Yu-Chun Wu , Guo-Ping Guo

This paper investigates novel techniques to solve prime factorization by quantum annealing (QA). Our contribution is twofold. First, we present a novel and very compact modular encoding of a binary multiplier circuit into the Pegasus…

Quantum Physics · Physics 2023-10-27 Jingwen Ding , Giuseppe Spallitta , Roberto Sebastiani

Solving continuous variable optimization problems by factorization machine quantum annealing (FMQA) demonstrates the potential of Ising machines to be extended as a solver for integer and real optimization problems. However, the details of…

Quantum Physics · Physics 2024-07-08 Katsuhiro Endo , Kazuaki Z. Takahashi

Mixed discrete-continuous optimization is central to engineering design, where discrete choices interact with continuous fields. These problems are difficult due to high-dimensional, complex search spaces. To tackle them, Quantum Annealing…

Computational Engineering, Finance, and Science · Computer Science 2026-03-19 Fabian Key , Lukas Freinberger , Mayu Muramatsu , Norbert Hosters

A black-box optimization algorithm such as Bayesian optimization finds extremum of an unknown function by alternating inference of the underlying function and optimization of an acquisition function. In a high-dimensional space, such…

Quantum Physics · Physics 2021-05-03 Syun Izawa , Koki Kitai , Shu Tanaka , Ryo Tamura , Koji Tsuda

Critical decision-making issues in science, engineering, and industry are based on combinatorial optimization; however, its application is inherently limited by the NP-hard nature of the problem. A specialized paradigm of analogue quantum…

Quantum Physics · Physics 2026-02-04 Rudraksh Sharma , Ravi Katukam , Arjun Nagulapally

This study investigates the application of Factorization Machines with Quantum Annealing (FMQA) to address the crystal structure problem (CSP) in materials science. FMQA is a black-box optimization algorithm that combines machine learning…

Detecting high-order epistasis is a fundamental challenge in genetic association studies due to the combinatorial explosion of candidate locus combinations. Although multifactor dimensionality reduction (MDR) is a widely used method for…

Machine Learning · Computer Science 2026-05-14 Shuta Kikuchi , Shu Tanaka

Quantum Annealing (QA) can efficiently solve combinatorial optimization problems whose objective functions are represented by Quadratic Unconstrained Binary Optimization (QUBO) formulations. For broader applicability of QA, quadratization…

Quantum Physics · Physics 2025-07-29 Hyakka Nakada , Shu Tanaka

Factorization Machine (FM) is the most commonly used model to build a recommendation system since it can incorporate side information to improve performance. However, producing item suggestions for a given user with a trained FM is…

Quantum Physics · Physics 2023-11-09 Chen-Yu Liu , Hsin-Yu Wang , Pei-Yen Liao , Ching-Jui Lai , Min-Hsiu Hsieh

Quantum annealing approximately solves combinatorial optimization problems by leveraging the principles of adiabatic quantum systems. In this approach, the system's Hamiltonian evolves from an initial general state to a problem-specific…

It was recently shown that quantum annealing can be used as an effective, fast subroutine in certain types of matrix factorization algorithms. The quantum annealing algorithm performed best for quick, approximate answers, but performance…

Machine Learning · Computer Science 2021-01-13 John Golden , Daniel O'Malley

In recent years, there is a growing interest in using quantum computers for solving combinatorial optimization problems. In this work, we developed a generic, machine learning-based framework for mapping continuous-space inverse design…

Quantum annealing is a heuristic algorithm for solving combinatorial optimization problems, and D-Wave Systems Inc. has developed hardware for implementing this algorithm. The current version of the D-Wave quantum annealer can solve…

Quantum Physics · Physics 2022-11-09 Shuntaro Okada , Masayuki Ohzeki , Shinichiro Taguchi

Conformation generation, also known as molecular unfolding (MU), is a crucial step in structure-based drug design, remaining a challenging combinatorial optimization problem. Quantum annealing (QA) has shown great potential for solving…

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