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The Highly-Adaptive-Lasso(HAL)-TMLE is an efficient estimator of a pathwise differentiable parameter in a statistical model that at minimal (and possibly only) assumes that the sectional variation norm of the true nuisance parameters are…

Statistics Theory · Mathematics 2017-09-01 Mark van der Laan

The Highly-Adaptive-LASSO Targeted Minimum Loss Estimator (HAL-TMLE) is an efficient plug-in estimator of a pathwise differentiable parameter in a statistical model that at minimal (and possibly only) assumes that the sectional variation…

Statistics Theory · Mathematics 2020-02-12 Weixin Cai , Mark van der Laan

Asymptotic efficiency of targeted maximum likelihood estimators (TMLE) of target features of the data distribution relies on a a second order remainder being asymptotically negligible. In previous work we proposed a nonparametric MLE termed…

Statistics Theory · Mathematics 2021-07-02 Mark van der Laan , Zeyi Wang , Lars van der Laan

Consider the case that we observe $n$ independent and identically distributed copies of a random variable with a probability distribution known to be an element of a specified statistical model. We are interested in estimating an infinite…

Statistics Theory · Mathematics 2017-09-20 Mark J. van der Laan , Aurélien F. Bibaut

We consider estimation of a functional parameter of a realistically modeled data distribution based on observing independent and identically distributed observations. We define an $m$-th order Spline Highly Adaptive Lasso Minimum Loss…

Statistics Theory · Mathematics 2021-07-05 Mark J. van der Laan , David Benkeser , Weixin Cai

We study nonparametric maximum likelihood estimation of a log-concave density function $f_0$ which is known to satisfy further constraints, where either (a) the mode $m$ of $f_0$ is known, or (b) $f_0$ is known to be symmetric about a fixed…

Statistics Theory · Mathematics 2019-05-15 Charles R. Doss , Jon A. Wellner

We consider estimation of a functional of the data distribution based on i.i.d. observations. We assume the target function can be defined as the minimizer of the expectation of a loss function over a class of $d$-variate real valued cadlag…

Statistics Theory · Mathematics 2023-02-01 Mark van der Laan

We solve the problem of estimating the distribution of presumed i.i.d. observations for the total variation loss. Our approach is based on density models and is versatile enough to cope with many different ones, including some density…

Statistics Theory · Mathematics 2024-01-05 Y. Baraud , H. Halconruy , G. Maillard

We address the challenge of performing Targeted Maximum Likelihood Estimation (TMLE) after an initial Highly Adaptive Lasso (HAL) fit. Existing approaches that utilize the data-adaptive working model selected by HAL-such as the relaxed HAL…

Methodology · Statistics 2025-06-23 Yi Li , Sky Qiu , Zeyi Wang , Mark van der Laan

We study a non-parametric approach to multivariate density estimation. The estimators are piecewise constant density functions supported by binary partitions. The partition of the sample space is learned by maximizing the likelihood of the…

Statistics Theory · Mathematics 2015-08-21 Linxi Liu , Wing Hung Wong

We study the problem of learning multivariate log-concave densities with respect to a global loss function. We obtain the first upper bound on the sample complexity of the maximum likelihood estimator (MLE) for a log-concave density on…

Statistics Theory · Mathematics 2018-12-06 Timothy Carpenter , Ilias Diakonikolas , Anastasios Sidiropoulos , Alistair Stewart

Maximum-likelihood estimation (MLE) is widely used in sequence to sequence tasks for model training. It uniformly treats the generation/prediction of each target token as multi-class classification, and yields non-smooth prediction…

Computation and Language · Computer Science 2018-12-13 Chengyue Gong , Xu Tan , Di He , Tao Qin

The log-concave maximum likelihood estimator of a density on the real line based on a sample of size $n$ is known to attain the minimax optimal rate of convergence of $O(n^{-4/5})$ with respect to, e.g., squared Hellinger distance. In this…

Statistics Theory · Mathematics 2016-09-06 Arlene K. H. Kim , Adityanand Guntuboyina , Richard J. Samworth

We study the problem of maximum likelihood estimation of densities that are log-concave and lie in the graphical model corresponding to a given undirected graph $G$. We show that the maximum likelihood estimate (MLE) is the product of the…

Statistics Theory · Mathematics 2025-12-02 Kaie Kubjas , Olga Kuznetsova , Elina Robeva , Pardis Semnani , Luca Sodomaco

Estimating and obtaining reliable inference for the marginally adjusted causal dose-response curve for continuous treatments without relying on parametric assumptions is a well-known statistical challenge. Parametric models risk introducing…

Methodology · Statistics 2025-08-29 Junming Shi , Wenxin Zhang , Alan E. Hubbard , Mark van der Laan

We study the problem of computing the maximum likelihood estimator (MLE) of multivariate log-concave densities. Our main result is the first computationally efficient algorithm for this problem. In more detail, we give an algorithm that, on…

Data Structures and Algorithms · Computer Science 2018-12-14 Ilias Diakonikolas , Anastasios Sidiropoulos , Alistair Stewart

We tackle the problem of high-dimensional nonparametric density estimation by taking the class of log-concave densities on $\mathbb{R}^p$ and incorporating within it symmetry assumptions, which facilitate scalable estimation algorithms and…

Statistics Theory · Mathematics 2019-03-15 Min Xu , Richard J. Samworth

Causal mediation analysis with random interventions has become an area of significant interest for understanding time-varying effects with longitudinal and survival outcomes. To tackle causal and statistical challenges due to the complex…

Methodology · Statistics 2023-04-12 Zeyi Wang , Lars van der Laan , Maya Petersen , Thomas Gerds , Kajsa Kvist , Mark van der Laan

We propose a scalable divergence estimation method based on hashing. Consider two continuous random variables $X$ and $Y$ whose densities have bounded support. We consider a particular locality sensitive random hashing, and consider the…

Information Theory · Computer Science 2018-01-03 Morteza Noshad , Alfred O. Hero

Lagrangian particle tracking is essential for characterizing turbulent flows, but inferring particle acceleration from inherently noisy position data remains a significant challenge. Fluid particles in turbulence experience extreme,…

Data Analysis, Statistics and Probability · Physics 2026-02-27 Griffin M Kearney , Kasey M Laurent , Makan Fardad
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