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MLLMs MLLMs are beginning to appear in clinical workflows, but their ability to perform complex medical reasoning remains unclear. We present Med-CMR, a fine-grained Medical Complex Multimodal Reasoning benchmark. Med-CMR distinguishes from…

Clinical document classification is essential for converting unstructured medical texts into standardised ICD-10 diagnoses, yet it faces challenges due to complex medical language, privacy constraints, and limited annotated datasets. Large…

Computation and Language · Computer Science 2026-02-03 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

Evaluating large language models (LLMs) for medical applications remains challenging due to benchmark saturation, limited data accessibility, and insufficient coverage of relevant tasks. Existing suites have either saturated, heavily depend…

Large language models (LLMs) hold transformative potential for medical decision support yet their application in psychiatry remains constrained by hallucinations and superficial reasoning. This limitation is particularly acute in…

Large Language Models (LLMs) have demonstrated substantial progress in biomedical and clinical applications, motivating rigorous evaluation of their ability to answer nuanced, evidence-based questions. We curate a multi-source benchmark…

Computation and Language · Computer Science 2025-09-16 Can Wang , Yiqun Chen

We introduce CRYSTAL (Clear Reasoning via Yielded Steps, Traceability, and Logic), a diagnostic benchmark with 6,372 instances that evaluates multimodal reasoning through verifiable intermediate steps. We propose two complementary metrics:…

Artificial Intelligence · Computer Science 2026-03-17 Wayner Barrios , SouYoung Jin

This study presents a comparative evaluation of 22 large language models LLMs on the Spanish Medical Intern Resident MIR examinations for 2024 and 2025 with a focus on clinical reasoning domain specific expertise and multimodal processing…

Large language models (LLMs) have demonstrated capabilities across diverse domains, yet their performance on rare disease diagnosis from narrative medical cases remains underexplored. We introduce a novel dataset of 176 symptom-diagnosis…

Computation and Language · Computer Science 2025-11-17 Arsh Gupta , Ajay Narayanan Sridhar , Bonam Mingole , Amulya Yadav

Test-time scaling via solution sampling and aggregation has become a key paradigm for improving the reasoning performance of Large Language Models (LLMs). While reward model selection is commonly employed in this approach, it often fails to…

Machine Learning · Computer Science 2025-09-30 Zhicheng Yang , Zhijiang Guo , Yinya Huang , Yongxin Wang , Yiwei Wang , Xiaodan Liang , Jing Tang

Specialized clinical AI assistants are rapidly entering medical practice, often framed as safer or more reliable than general-purpose large language models (LLMs). Yet, unlike frontier models, these clinical tools are rarely subjected to…

Computation and Language · Computer Science 2025-12-02 Krithik Vishwanath , Mrigayu Ghosh , Anton Alyakin , Daniel Alexander Alber , Yindalon Aphinyanaphongs , Eric Karl Oermann

Large language models (LLMs) show promise in automating clinical diagnosis, yet their non-transparent decision-making and limited alignment with diagnostic standards hinder trust and clinical adoption. We address this challenge by proposing…

Artificial Intelligence · Computer Science 2025-11-25 Yining Yuan , J. Ben Tamo , Micky C. Nnamdi , Yifei Wang , May D. Wang

Multimodal large language models (MLLMs) demonstrate considerable potential in clinical diagnostics, a domain that inherently requires synthesizing complex visual and textual data alongside consulting authoritative medical literature.…

Computation and Language · Computer Science 2026-03-23 Yannian Gu , Zhongzhen Huang , Linjie Mu , Xizhuo Zhang , Shaoting Zhang , Xiaofan Zhang

Recent advancements in reasoning-enhanced large language models (LLMs), such as DeepSeek-R1 and OpenAI-o3, have demonstrated significant progress. However, their application in professional medical contexts remains underexplored,…

Computation and Language · Computer Science 2025-03-11 Pengcheng Qiu , Chaoyi Wu , Shuyu Liu , Weike Zhao , Zhuoxia Chen , Hongfei Gu , Chuanjin Peng , Ya Zhang , Yanfeng Wang , Weidi Xie

While Large language models (LLMs) have the capability to iteratively reflect on their own outputs, recent studies have observed their struggles with knowledge-rich problems without access to external resources. In addition to the…

Computation and Language · Computer Science 2024-06-25 Hanqi Yan , Qinglin Zhu , Xinyu Wang , Lin Gui , Yulan He

Closed-source large language models (LLMs), such as ChatGPT and Gemini, are increasingly consulted for medical advice, yet their explanations may appear plausible while failing to reflect the model's underlying reasoning process. This gap…

This study evaluates how well large language models (LLMs) can classify ICD-10 codes from hospital discharge summaries, a critical but error-prone task in healthcare. Using 1,500 summaries from the MIMIC-IV dataset and focusing on the 10…

Computation and Language · Computer Science 2025-07-08 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

LLMs have demonstrated strong performance in data-rich domains such as programming, yet their reliability in engineering tasks remains limited. Circuit analysis--requiring multimodal understanding and precise mathematical…

Computers and Society · Computer Science 2026-04-17 Liangliang Chen , Weiyu Sun , Huiru Xie , Yongnuo Cai , Ying Zhang

Large Language models (LLMs) have demonstrated state-of-the-art performance in various natural language processing (NLP) tasks across multiple domains, yet they are prone to shortcut learning and factual inconsistencies. This research…

Computation and Language · Computer Science 2024-04-09 Shreyasi Mandal , Ashutosh Modi

Large language models (LLMs) excel on many NLP benchmarks, but their behavior on real-world, semi-structured prediction remains underexplored. We present LlaMADRS, a benchmark for structured clinical assessment from dialogue built on the…

Human-Computer Interaction · Computer Science 2026-04-23 Gaoussou Youssouf Kebe , Jeffrey M. Girard , Einat Liebenthal , Justin Baker , Fernando De la Torre , Louis-Philippe Morency

Large language models (LLMs) have advanced medical dialogue systems, yet psychiatric consultation poses substantially higher demands due to subjective ambiguity and comorbidity complexity: an agent must continuously extract…

Computation and Language · Computer Science 2026-03-05 Guoyi Li , Shihao Xu , Jiatong Ma , Yunyun Han , Jianhua Chen , Yafeng Deng
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