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In many applications, data can be heterogeneous in the sense of spanning latent groups with different underlying distributions. When predictive models are applied to such data the heterogeneity can affect both predictive performance and…

Machine Learning · Statistics 2022-05-04 Thomas Lartigue , Sach Mukherjee

Temporal information in structured electronic health records (EHRs) is often lost in sparse one-hot or count-based representations, while sequence models can be costly and data-hungry. We propose PaReGTA, an LLM-based encoding framework…

Machine Learning · Computer Science 2026-03-03 Kihyuk Yoon , Lingchao Mao , Catherine Chong , Todd J. Schwedt , Chia-Chun Chiang , Jing Li

The widespread application of Electronic Health Records (EHR) data in the medical field has led to early successes in disease risk prediction using deep learning methods. These methods typically require extensive data for training due to…

Machine Learning · Computer Science 2024-11-28 Shibo Li , Hengliang Cheng , Weihua Li

Sequential multiple assignment randomized trials (SMARTs) provide a systematic framework for constructing and evaluating dynamic treatment regimens (DTRs). In clinical studies, longitudinal biomarkers are routinely collected to monitor…

Methodology · Statistics 2026-05-06 Zhengxi Chen , Holly Hartman

The discovery of clinical biomarkers requires large patient cohorts and is aided by a pooled data approach across institutions. In many countries, data protection constraints, especially in the clinical environment, forbid the exchange of…

Machine Learning · Statistics 2023-10-03 Daniela Zöller , Harald Binder

Artificial intelligence (AI) has demonstrated significant potential in transforming healthcare through the analysis and modeling of electronic health records (EHRs). However, the inherent heterogeneity, temporal irregularity, and…

Machine Learning · Computer Science 2025-07-18 Weijieying Ren , Jingxi Zhu , Zehao Liu , Tianxiang Zhao , Vasant Honavar

Varying coefficient models are widely used to characterize dynamic associations between longitudinal outcomes and covariates. Existing work on varying coefficient models, however, all assumes that observation times are independent of the…

Methodology · Statistics 2026-01-27 Yu Gu , Yangjianchen Xu , Peijun Sang

In time-to-event analyses in social sciences, there often exist endogenous time-varying variables, where the event status is correlated with the trajectory of the covariate itself. Ignoring this endogeneity will result in biased estimates.…

Applications · Statistics 2025-04-28 Sophie Potts , Anja Rappl , Karin Kurz , Elisabeth Bergherr

Dropout represents a typical issue to be addressed when dealing with longitudinal studies. If the mechanism leading to missing information is non-ignorable, inference based on the observed data only may be severely biased. A frequent…

Methodology · Statistics 2018-03-23 Maria Francesca Marino , Marco Alfo'

We propose a new approach to the semiparametric analysis of panel data binary choice models with fixed effects and dynamics (lagged dependent variables). The model we consider has the same random utility framework as in Honore and…

Econometrics · Economics 2025-09-03 Fu Ouyang , Thomas Tao Yang

There is an emerging trend in the reinforcement learning for healthcare literature. In order to prepare longitudinal, irregularly sampled, clinical datasets for reinforcement learning algorithms, many researchers will resample the time…

Machine Learning · Computer Science 2019-11-19 Scott L. Fleming , Kuhan Jeyapragasan , Tony Duan , Daisy Ding , Saurabh Gombar , Nigam Shah , Emma Brunskill

Feature engineering for Electronic Health Records (EHR) is complicated by irregular observation intervals, variable measurement frequencies, and structural sparsity inherent to clinical time series. Existing automated methods either lack…

Machine Learning · Computer Science 2026-04-27 Hojjat Karami , David Atienza , Jean-Philippe Thiran , Anisoara Ionescu

Medical time series are often irregular and face significant missingness, posing challenges for data analysis and clinical decision-making. Existing methods typically adopt a single modeling perspective, either treating series data as…

Computer Vision and Pattern Recognition · Computer Science 2025-05-27 Liuqing Chen , Shuhong Xiao , Shixian Ding , Shanhai Hu , Lingyun Sun

Learning electronic health records (EHRs) has received emerging attention because of its capability to facilitate accurate medical diagnosis. Since the EHRs contain enriched information specifying complex interactions between entities,…

Machine Learning · Computer Science 2024-08-15 Tsai Hor Chan , Guosheng Yin , Kyongtae Bae , Lequan Yu

The electronic health record (EHR) provides an unprecedented opportunity to build actionable tools to support physicians at the point of care. In this paper, we investigate survival analysis in the context of EHR data. We introduce deep…

Machine Learning · Statistics 2016-09-20 Rajesh Ranganath , Adler Perotte , Noémie Elhadad , David Blei

Whole-brain network analyses remain the vanguard in neuroimaging research, coming to prominence within the last decade. Network science approaches have facilitated these analyses and allowed examining the brain as an integrated system.…

Applications · Statistics 2015-05-04 Sean L. Simpson , Paul J. Laurienti

Synthesizing electronic health records (EHR) data has become a preferred strategy to address data scarcity, improve data quality, and model fairness in healthcare. However, existing approaches for EHR data generation predominantly rely on…

Machine Learning · Computer Science 2024-06-21 Yuan Zhong , Xiaochen Wang , Jiaqi Wang , Xiaokun Zhang , Yaqing Wang , Mengdi Huai , Cao Xiao , Fenglong Ma

Objectives: In the United States, 25% of people with type 2 diabetes are undiagnosed. Conventional screening models use limited demographic information to assess risk. We evaluated whether electronic health record (EHR) phenotyping could…

Quantitative Methods · Quantitative Biology 2015-01-13 Ariana E. Anderson , Wesley T. Kerr , April Thames , Tong Li , Jiayang Xiao , Mark S. Cohen

Deep learning-based predictive models, leveraging Electronic Health Records (EHR), are receiving increasing attention in healthcare. An effective representation of a patient's EHR should hierarchically encompass both the temporal…

Machine Learning · Computer Science 2024-05-08 Jiayuan Chen , Changchang Yin , Yuanlong Wang , Ping Zhang

Difficulties may arise when analyzing longitudinal data using mixed-effects models if there are nonparametric functions present in the linear predictor component. This study extends the use of semiparametric mixed-effects modeling in cases…

Methodology · Statistics 2024-02-05 Mozhgan Taavoni , Mohammad Arashi
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